Microfibril-associated glycoproteins MAGP-1 and MAGP-2 in disease

Abstract

Microfibril-associated glycoproteins 1 and 2 (MAGP-1, MAGP-2) are protein components of extracellular matrix microfibrils. These proteins interact with fibrillin, the core component of microfibrils, and impart unique biological properties that influence microfibril function in vertebrates. MAGPs bind active forms of TGFβ and BMPs and are capable of modulating Notch signaling. Mutations in MAGP-1 or MAGP-2 have been linked to thoracic aneurysms and metabolic disease in humans. MAGP-2 has also been shown to be an important biomarker in several human cancers. Mice lacking MAGP-1 or MAGP-2 have defects in multiple organ systems, which reflects the widespread distribution of microfibrils in vertebrate tissues. This review summarizes our current understanding of the function of the MAGPs and their relationship to human disease.

<p>MFAP2 is a Potential Diagnostic and Prognostic Biomarker That Correlates with the Progression of Papillary Thyroid Cancer</p>

“…Microfibrillar-associated proteins (MFAPs) are a group of extracellular matrix glycoproteins including five subfamily members (MFAP1~5), these proteins have been reported to play a role in microfibril assembly and tissue homeostasis. [10][11][12] Among these five members, Microfibrilassociated protein 2 (MFAP2, also known as MAGP-1), with its coding gene located at 1p36.13, was reported to be associated with different kinds of malignant cancers in recent years. Chen et al showed that MFAP2 was overexpressed in melanoma and promoted invasion and migration abilities of melanoma through regulating the EMT-related proteins and Wnt/beta-catenin pathway.…”

MFAP2 Promotes the Proliferation of Cancer Cells and Is Associated With a Poor Prognosis in Hepatocellular Carcinoma

“…Microfibrillar-associated protein 2 (MFAP2), also known as microfibril-associated glycoprotein 1 (MAGP1), is a component of extracellular elastic microfibrils, which interacts with fibrillin to influence the function of microfibers. 3 , 4 MFAP2 is the most widely distributed protein of MAGPs and a component protein of microfibrils in most vertebrates. A prominent feature of this protein is its ability to interact with TGF-β family growth factors, Notch and Notch ligands, and a variety of elastic fibrin.…”

Overexpressed MAGP1 Is Associated With a Poor Prognosis and Promotes Cell Migration and Invasion in Gastric Cancer

“…In this study, we focused on MAGP1 since few studies had explored the relationship between MAGP1 and cancer, except the role in obesity, thermogenesis and homeostasis (12,27). We found that MAGP1 was overexpressed in most digestive system tumors like gastric cancer, cholangiocarcinoma, esophageal cancer, colon cancer, and rectal adenocarcinoma.…”

“…Microfibril associated glycoprotein 1 (MAGP1), a small extracellular matrix molecule (21 kDa), is coded by the MFAP2 gene that is located on human chromosome 1p31 (11,12). Its Cterminal end includes a matrix-binding domain (MBD) which tethers it to the extracellular matrix (ECM) (11,12).…”

“…Microfibril associated glycoprotein 1 (MAGP1), a small extracellular matrix molecule (21 kDa), is coded by the MFAP2 gene that is located on human chromosome 1p31 (11,12). Its Cterminal end includes a matrix-binding domain (MBD) which tethers it to the extracellular matrix (ECM) (11,12). Previous studies established MAGP1 as a protective factor in obesity and diabetes, which promoted thermogenesis by regulating the TGF-β/Smad3 signaling pathway (13).…”