Microfluidic-Assisted Production of Size-Controlled Superparamagnetic Iron Oxide Nanoparticles-Loaded Poly(methyl methacrylate) Nanohybrids

Ding, Shukai; Attia, Mohamed F.; Wallyn, Justine; Taddei, Chiara; Serra, Christophe A.; Anton, Nicolas; Kassem, Mohamad; Schmutz, Marc; Er-Rafik, Mériem; Messaddeq, Nadia; Collard, Alexandre; Yu, Wei; Giordano, M.; Vandamme, Thierry F.

doi:10.1021/acs.langmuir.7b01928

Cited by 18 publications

(11 citation statements)

References 65 publications

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“…Comparing to the conventional nanosystems, nanohybrids exhibit enhanced biocompatibility, stability, catalytic properties, and hierarchical control . Among which, nanohybrids with identical core/shell structures, such as organic/inorganic nanohybrids, inorganic/inorganic nanohybrids, and lipid/polymer nanohybrids have been widely investigated. The previous bulk methods used to produce core/shell nanosystems usually contains two independent steps to separately prepare the core structure and the sequential shell coating, and thus often exhibit poor control over the encapsulation efficiency and reproducibility.…”

Section: Microfluidic Production Of Nanoparticlesmentioning

confidence: 99%

Microfluidics for Production of Particles: Mechanism, Methodology, and Applications

Liu

Fontana

Python

et al. 2019

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In the past two decades, microfluidics‐based particle production is widely applied for multiple biological usages. Compared to conventional bulk methods, microfluidic‐assisted particle production shows significant advantages, such as narrower particle size distribution, higher reproducibility, improved encapsulation efficiency, and enhanced scaling‐up potency. Herein, an overview of the recent progress of the microfluidics technology for nano‐, microparticles or droplet fabrication, and their biological applications is provided. For both nano‐, microparticles/droplets, the previously established mechanisms behind particle production via microfluidics and some typical examples during the past five years are discussed. The emerging interdisciplinary technologies based on microfluidics that have produced microparticles or droplets for cellular analysis and artificial cells fabrication are summarized. The potential drawbacks and future perspectives are also briefly discussed.

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Section: Microfluidic Production Of Nanoparticlesmentioning

confidence: 99%

Microfluidics for Production of Particles: Mechanism, Methodology, and Applications

Liu

Fontana

Python

et al. 2019

Small

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“…Stereolithograpy, 3D printers, microablation technologies have been widely used to fabricate scaffolds with a well-defined geometry but the main disadvantages of these techniques are poor cost effectiveness and complicated procedures. On the other hand, microfluidic technology makes it possible to produce scaffolds by one step with very low cost [21][22] . Therefore, we investigated micro-droplet formation in the T-junction channel and collected the resulting products on a glass slide at the end of the tip, directly.…”

Section: Introductionmentioning

confidence: 99%

Honeycomb-like PLGA-b-PEG Structure Creation with T-Junction Microdroplets

Gultekinoglu¹,

Jiang

Bayram³

et al. 2018

Langmuir

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Amphiphilic block copolymers are widely used in science owing to their versatile properties. In this study, amphiphilic block copolymer poly(lactic- co-glycolic acid)- block-poly(ethylene glycol) (PLGA- b-PEG) was used to create microdroplets in a T-junction microfluidic device with a well-defined geometry. To compare interfacial characteristics of microdroplets, dichloromethane (DCM) and chloroform were used to prepare PLGA- b-PEG solution as an oil phase. In the T-junction device, water and oil phases were manipulated at variable flow rates from 50 to 300 μL/min by increments of 50 μL/min. Fabricated microdroplets were directly collected on a glass slide. After a drying period, porous two-dimensional and three-dimensional structures were obtained as honeycomb-like structure. Pore sizes were increased according to increased water/oil flow rate for both DCM and chloroform solutions. Also, it was shown that increasing polymer concentration decreased the pore size of honeycomb-like structures at a constant water/oil flow rate (50:50 μL/min). Additionally, PLGA- b-PEG nanoparticles were also obtained on the struts of honeycomb-like structures according to the water solubility, volatility, and viscosity properties of oil phases, by the aid of Marangoni flow. The resulting structures have a great potential to be used in biomedical applications, especially in drug delivery-related studies, with nanoparticle forming ability and cellular responses in different surface morphologies.

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“…Microfluidic chips have also answered this need by synthesizing coated magnetic nanoparticles. For example, researchers have reported the microfluidic-based synthesis of ~6 nm iron oxide magnetic nanoparticles encapsulated in poly(methyl methacrylate) with a total size of 100–200 nm [ 38 ]. Furthermore, scientists have reported magnetic nanoparticles loaded with a drug and molecules specific to a target tissue.…”

Section: Synthesismentioning

confidence: 99%

Microfluidic Synthesis, Control, and Sensing of Magnetic Nanoparticles: A Review

2021

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Magnetic nanoparticles have attracted significant attention in various disciplines, including engineering and medicine. Microfluidic chips and lab-on-a-chip devices, with precise control over small volumes of fluids and tiny particles, are appropriate tools for the synthesis, manipulation, and evaluation of nanoparticles. Moreover, the controllability and automation offered by the microfluidic chips in combination with the unique capabilities of the magnetic nanoparticles and their ability to be remotely controlled and detected, have recently provided tremendous advances in biotechnology. In particular, microfluidic chips with magnetic nanoparticles serve as sensitive, high throughput, and portable devices for contactless detecting and manipulating DNAs, RNAs, living cells, and viruses. In this work, we review recent fundamental advances in the field with a focus on biomedical applications. First, we study novel microfluidic-based methods in synthesizing magnetic nanoparticles as well as microparticles encapsulating them. We review both continues-flow and droplet-based microreactors, including the ones based on the cross-flow, co-flow, and flow-focusing methods. Then, we investigate the microfluidic-based methods for manipulating tiny magnetic particles. These manipulation techniques include the ones based on external magnets, embedded micro-coils, and magnetic thin films. Finally, we review techniques invented for the detection and magnetic measurement of magnetic nanoparticles and magnetically labeled bioparticles. We include the advances in anisotropic magnetoresistive, giant magnetoresistive, tunneling magnetoresistive, and magnetorelaxometry sensors. Overall, this review covers a wide range of the field uniquely and provides essential information for designing “lab-on-a-chip” systems for synthesizing magnetic nanoparticles, labeling bioparticles with them, and sorting and detecting them on a single chip.

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Microfluidic-Assisted Production of Size-Controlled Superparamagnetic Iron Oxide Nanoparticles-Loaded Poly(methyl methacrylate) Nanohybrids

Cited by 18 publications

References 65 publications

Microfluidics for Production of Particles: Mechanism, Methodology, and Applications

Microfluidics for Production of Particles: Mechanism, Methodology, and Applications

Honeycomb-like PLGA-b-PEG Structure Creation with T-Junction Microdroplets

Microfluidic Synthesis, Control, and Sensing of Magnetic Nanoparticles: A Review

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