Microfluidic chip-based long-term preservation and culture of engineering bacteria for DNA damage evaluation

Wang, Wenjia; Yu, Yue; Li, Xiaoqiong; Xu, Jing; Pei, Renjun; Deng, Yulin; Lv, Xuefei

doi:10.1007/s00253-022-11797-2

Cited by 4 publications

(1 citation statement)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Microfluidics is an interdisciplinary field encompassing the study and manipulation of fluids at the microscale level, typically within channels ranging from 100 μm to 1 mm in diameter. 5 This field has gained considerable attention in recent years due to its potential applications in a wide range of fields, including medicine, 6 biology, 7 chemistry, 8 environmental science, 9 microchannels, micropumps, and microvalves. 10 The fabrication process employs materials such as glass, silicon, and polymers, and involves photolithography, etching, and bonding.…”

Section: Introductionmentioning

confidence: 99%

AI-Powered Microfluidics: Shaping the Future of Phenotypic Drug Discovery

Liu,

Du,

Huang

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Phenotypic drug discovery (PDD), which involves harnessing biological systems directly to uncover effective drugs, has undergone a resurgence in recent years. The rapid advancement of artificial intelligence (AI) over the past few years presents numerous opportunities for augmenting phenotypic drug screening on microfluidic platforms, leveraging its predictive capabilities, data analysis, efficient data processing, etc. Microfluidics coupled with AI is poised to revolutionize the landscape of phenotypic drug discovery. By integrating advanced microfluidic platforms with AI algorithms, researchers can rapidly screen large libraries of compounds, identify novel drug candidates, and elucidate complex biological pathways with unprecedented speed and efficiency. This review provides an overview of recent advances and challenges in AI-based microfluidics and their applications in drug discovery. We discuss the synergistic combination of microfluidic systems for high-throughput screening and AI-driven analysis for phenotype characterization, drug-target interactions, and predictive modeling. In addition, we highlight the potential of AI-powered microfluidics to achieve an automated drug screening system. Overall, AI-powered microfluidics represents a promising approach to shaping the future of phenotypic drug discovery by enabling rapid, cost-effective, and accurate identification of therapeutically relevant compounds.

show abstract

Section: Introductionmentioning

confidence: 99%

AI-Powered Microfluidics: Shaping the Future of Phenotypic Drug Discovery

Liu,

Du,

Huang

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

Nanomedicine: Present Perspectives and Future Challenges

Ali,

Sadia,

Tariq

2023

Learning Materials in Biosciences

View full text Add to dashboard Cite

Lab-on-chip technologies for space research — current trends and prospects

Krakos

2023

Microchim Acta

View full text Add to dashboard Cite

The in-depth analysis concerning application of microfluidic instruments for space biology research is presented. The article focuses on recently investigated key scientific fields, i.e., lab-on-chips applied to the biomedical studies performed in the (1) International Space Station and (2) CubeSat nanosatellites. The paper presents also the lab-on-chip devices that were fabricated with a view to future space biology research and to those that to date have been solely been tested under Earth laboratory conditions and/or simulated microgravity environments. NASA and ESA conceptual mission plans for future are also mentioned, concerning for instance “tissue chips” and the ESA-SPHEROIDS campaign. The paper ends with final conclusions and future perspectives regarding lab-on-chip application in the space biology sector and its impact on novel biomedical and pharmaceutical strategies. Graphical Abstract

show abstract

Microfluidic chip-based long-term preservation and culture of engineering bacteria for DNA damage evaluation

Cited by 4 publications

References 52 publications

AI-Powered Microfluidics: Shaping the Future of Phenotypic Drug Discovery

AI-Powered Microfluidics: Shaping the Future of Phenotypic Drug Discovery

Nanomedicine: Present Perspectives and Future Challenges

Lab-on-chip technologies for space research — current trends and prospects

Contact Info

Product

Resources

About