Microfluidic chip reactor and the stereoselective hydrogenation of methylacetoacetate over (R) -Ru-BINAP in the [N 8222 ][Tf 2 N]/methanol/water mixed phase

Klusoň, Petr; Stavárek, Petr; Pěnkavová, Věra; Vychodilova, Hana; Hejda, Stanislav; Bendová, Magdalena

doi:10.1016/j.cep.2017.02.002

Cited by 17 publications

(7 citation statements)

References 30 publications

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“…They further used the same microfluidic chip reactor to design the reversible biphasic arrangement for asymmetric hydrogenations of MAA. 116 Tsanaktsidis and co-workers custom built a catalytic static mixer (CSM), for the synthesis of a key intermediate of the antimicrobial drug linezolid (Zyvox). The approach combined three-dimensional (3D) printing and additive manufacturing techniques.…”

Section: Reaction Chemistry and Engineering Reviewmentioning

confidence: 99%

Application of reactor engineering concepts in continuous flow chemistry: a review

Neyt

Riley

2021

React. Chem. Eng.

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Section: Reaction Chemistry and Engineering Reviewmentioning

confidence: 99%

Application of reactor engineering concepts in continuous flow chemistry: a review

Neyt

Riley

2021

React. Chem. Eng.

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“…[41,59] In other words, even multistep processes with many inlet streams can be quickly designed thanks to the modularity of microcapillary systems. [19,52] Microreactors conventionally consist of microfluidic chips (Figure 1(b)) containing straight or meandering channels and channel bifurcations [15,16,20,40,44,45,50,57,61,62,65,67,[71][72][73]77] and are built using various techniques, including advanced photolithography, soft lithography, micromachining, and 3D printing. Photolithography, soft lithography, electroerosion, and other techniques generate microchannels or embedded structures, such as electrodes with various characteristic dimensions, ranging from several microns to millimeters.…”

Section: Reactor Materials and Designmentioning

confidence: 99%

“…Reaction parameters [39] tens or hundreds of microns. The main materials used to manufacture microfluidic chips include glass, [15,40,44,45,56,61,62,65,71,72] which provide microreactors with high chemical resistance, cycloolefins, [20] which are a less expensive alternative to glass, stainless steel, [57] noble metals, [68,77] or various polymers, such as PMMA, [73] and polylactic acid. [50] Polymers are usually optically transparent and suitable for applications in an aqueous environment under mild conditions.…”

Section: Reactor Materials and Dimensionmentioning

confidence: 99%

“…These microreactors contain one, two, or more phases, which actively participate in a chemical reaction. A similar number of studies have focused on homogeneous (single-phase) [15,16,[38][39][40][41]45,48,49,52,53,57,[59][60][61]65,73] and heterogeneous (multiphase) reactors, [17][18][19][20][42][43][44]47,50,51,54,56,58,[62][63][64][66][67][68][69][70][71][72]74,76,77] as outlined in Table 1.…”

Section: Microreactors and Their Benefits For Enantiomer And Diastereoisomer Synthesismentioning

confidence: 99%

“…The typical microreactors of this group are systems with two or more immiscible liquid phases [56,66,67,71,72] or with one gas phase and one or more liquid phases. [44,78] The liquid-liquid flow takes the form of slug/droplet (Figure 2(a)) or parallel (Figure 2(b)) flow in microreactors. [66,67,71,72] Parallel flow provides an intensive interfacial transport of reactants/products between phases thanks to short transport distances.…”

Section: Multiple-phase Reactorsmentioning

confidence: 99%

See 2 more Smart Citations

Microreaction and membrane technologies for continuous single-enantiomer production: A review

et al. 2021

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Microreaction and membrane technologies offer optimal conditions for controlling enantiomer synthesis and purification processes in continuous production, with numerous advantages over batch manufacturing. One of the many forces driving the development of such technologies for the production of single optical isomers is the need for enantiomerically pure pharmaceutical drugs because enantiomers may display opposite therapeutic effects or different treatment efficacies and side effects. Yet, despite advances in asymmetric synthesis and separation techniques, preparing enantiomerically pure compounds remains a challenging task. Here, we review the progress in microfluidics and membrane chiral separation over the last two decades. In addition to describing and critically assessing the state of the art in both disciplines, we provide an overview of their beneficial properties and characteristics for developing technologies toward producing enantiomerically pure compounds. Concomitantly, we evaluate efforts to integrate synthesis and membrane separation into a microfluidic platform and pinpoint the limiting factors that must be overcome before these platforms can be fully deployed in the industry.

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Chemical Engineering View on the Silicone Oil Utilization in the Treatment of Retinal Detachment

Reháčková,

Veith,

Stavárek

et al. 2024

ChemBioEng Reviews

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Retinal detachment is an acute condition in ophthalmology that needs an immediate surgical management. The treatment requires a replacement of the vitreous with a temporary substitute, usually based on a silicone oil. A certain number of patients experience adverse events during the treatment. It seems this phenomenon is related to the formation of emulsions in the affected eye. These appear macroscopically as heterogeneities resembling small droplets with a patchy occurrence in the vitreous substitute. Their existence represents a major complication that may lead to loss of vision. The heterogeneities are transported to regions of the eye in which they cause irreversible damage. The current state of knowledge describes the phenomenon and recommends certain intervention procedures. Here, specific attention is paid to the chemical engineering aspects of the utilization of silicone oils for the treatment of the retinal detachment. It is very likely that the process of tiny droplet formation leading to the development of emulsions is substantially controlled by the hydrodynamic conditions in the eye. The complexity of this statement is examined in this review text.

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Microfluidic chip reactor and the stereoselective hydrogenation of methylacetoacetate over (R) -Ru-BINAP in the [N 8222 ][Tf 2 N]/methanol/water mixed phase

Cited by 17 publications

References 30 publications

Application of reactor engineering concepts in continuous flow chemistry: a review

Application of reactor engineering concepts in continuous flow chemistry: a review

Microreaction and membrane technologies for continuous single-enantiomer production: A review

Chemical Engineering View on the Silicone Oil Utilization in the Treatment of Retinal Detachment

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