Microfluidic circuits and systems

Sapuppo, F.; Schembri, Florinda; Fortuna, Luigi; Bucolo, Maide

doi:10.1109/mcas.2009.933853

Cited by 21 publications

(11 citation statements)

References 49 publications

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“…In the last decade the two-phase microfluidics has contributed in many biological, chemical and medical researches [2,7,19] . The bi-phase flows can be obtained considering two immiscible fluids or micro-particles dispersed in a fluid, with a certain concentration [16] .…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of spatial irregularities in RBCs flows

Cairone

Mirabella

Cabrales

et al. 2018

Chaos, Solitons & Fractals

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The spatial irregularities of red blood cells (RBCs) in continuous pulsing flow condition in micro-channels were investigated by analyzing the time variability of optical signatures obtained by recording transmitted light variability at specific location in micro-flow channels. Different flow conditions were filmed and analyzed by the digital particle image velocimetry (DPIV) to characterize local flow velocity across the whole micro-channel and in four sub-areas selected to study the particles behaviors close to the walls and in the micro-channel bulk. Starting from a behavioral classification based on the three flow patterns identified as { Weak Activity, Vorticity, Alignment }, an analysis to detect the spatial irregularity in the flow distribution was carried out. The velocity gradients and four nonlinear parameters (shear rate, strain rate, vorticity, divergence) were computed from the time-varying velocity maps obtained by DPIV and used to provide a quantitative characterization of the flow features. The comparison of the results obtained in the four experiments has made possible an overall understanding of the RBC movements in different conditions and, as well, the establishment of a analysis procedure for flows spatial irregularity detection.

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Section: Introductionmentioning

confidence: 99%

Quantitative analysis of spatial irregularities in RBCs flows

Cairone

Mirabella

Cabrales

et al. 2018

Chaos, Solitons & Fractals

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“…The advantages of CMOS sensors are that they can be designed to incorporate large numbers of sensing pixels to improve the sensing throughput, and to incorporate multiple biomedical sensing capabilities such as optical or electrochemical sensing [13][14][15][16]. Microfluidics, which deals with the manipulation of fluidic samples at microscale volume, are just suitable for preparation and delivery of biomedical samples such as cells or bacterium in an aqueous environment to CMOS sensing sites [17][18][19]. In addition, microfluidic package can encapsulate and protect other electrical part of the CMOS sensor chip.…”

Section: Introductionmentioning

confidence: 99%

A Surface Acoustic Wave Pumped Lensless Microfluidic Imaging System for Flowing Cell Detection and Counting

Huang

Farooq

Chen

et al. 2017

IEEE Trans. Biomed. Circuits Syst.

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The future point-of-care diagnostics requires miniaturizing the existing bulky and expensive bioanalysis instruments, where lab-on-CMOS-chip-based technology can provide a promising solution. In this paper, we presented a surface acoustic wave (SAW) pumped lensless microfluidic imaging system for flowing cell detection and counting. Different from the previous lensless systems, which employ external bulky syringe pump for cell driven, the developed system directly integrates the SAW pump on the CMOS image sensor chip to drive the cell-containing microfluid. Moreover, an efficient temporal-differencing-based motion detection algorithm is proposed for continuous flowing cell detection and counting. Experimental results show that the SAW pump can drive the cells to flow at different driven powers, and also can keep the channel temperature below 40 °C so as not to harm the cells. The human bone marrow stromal cells flowing in the microfluidic channel can be automatically detected and counted with a low statistical error rate of -6.53%. The developed system thereby is competitive for point-of-care cell detection and counting application.

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“…A recent work of Willaime et al (2006) shows experimentally how local periodic forcing may give rise to synchronized and quasiperiodic regimes of droplets' flow, organized into Arnold tongues. In this contest it is evident that patterns' formation is strongly influenced by input flow rates, and so they play a key role on process dynamics (Joanicot et al 2005;Sapuppo et al 2009). …”

Section: Introductionmentioning

confidence: 99%

Periodic input flows tuning nonlinear two-phase dynamics in a snake microchannel

Schembri

Bucolo

2011

Microfluid Nanofluid

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In this experimental study, the effects on twophase flow dynamics in a microfluidic snake channel due to periodic forcing were considered. Time series analysis was exploited to investigate on the obtained bubbles' flow considering two aspects: the role of driven frequency through Fourier analysis and the nonlinear behavior through the evaluation of d-infinite and Largest Lyapunov exponent. Phase diagrams summarize the results: the two nonlinear parameters are plotted versus the air fraction and the frequency of the input flow rates. The identified relation maps allow the classification of the flow dynamics, opening the way for the control of bubble flow through signal analysis.

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Microfluidic circuits and systems

Cited by 21 publications

References 49 publications

Quantitative analysis of spatial irregularities in RBCs flows

Quantitative analysis of spatial irregularities in RBCs flows

A Surface Acoustic Wave Pumped Lensless Microfluidic Imaging System for Flowing Cell Detection and Counting

Periodic input flows tuning nonlinear two-phase dynamics in a snake microchannel

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