Microfluidic conceived Trojan microcarriers for oral delivery of nanoparticles

Khan, Ikram Ullah; Serra, Christophe A.; Anton, Nicolas; Er-Rafik, Mériem; Blanck, Christian; Schmutz, Marc; Kraus, Isabelle; Messaddeq, Nadia; Sutter, Christophe; Anton, Halina; Klymchenko, Andrey S.; Vandamme, Thierry F.

doi:10.1016/j.ijpharm.2015.06.028

Cited by 18 publications

(18 citation statements)

References 27 publications

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“…The system working at total flow rate as high as 323 mL/min produced nanocapsules with a size of 193 nm and PDI of 0.109. This flow rate value is an order of magnitude higher than that previously reported in the scientific literature [ 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 ]. Higher flow rates were not tested, but the system is not limited to the previously mentioned value.…”

Section: Microfluidic Devices For Chemical Process Implementationmentioning

confidence: 53%

“…It also aims for the production of nanocapsules for the pharmaceutical industry. For this, the system should be able to work at flow rates higher than that currently reported in the literature, which is approximately 40 mL/min for emulsion generation with micromixers [ 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 ].…”

Section: Microfluidic Devices For Chemical Process Implementationmentioning

confidence: 99%

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Fab on a Package: LTCC Microfluidic Devices Applied to Chemical Process Miniaturization

et al. 2018

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Microfluidics has brought diverse advantages to chemical processes, allowing higher control of reactions and economy of reagents and energy. Low temperature co-fired ceramics (LTCC) have additional advantages as material for fabrication of microfluidic devices, such as high compatibility with chemical reagents with typical average surface roughness of 0.3154 μm, easy scaling, and microfabrication. The conjugation of LTCC technology with microfluidics allows the development of micrometric-sized channels and reactors exploiting the advantages of fast and controlled mixing and heat transfer processes, essential for the synthesis and surface functionalization of nanoparticles. Since the chemical process area is evolving toward miniaturization and continuous flow processing, we verify that microfluidic devices based on LTCC technology have a relevant role in implementing several chemical processes. The present work reviews various LTCC microfluidic devices, developed in our laboratory, applied to chemical process miniaturization, with different geometries to implement processes such as ionic gelation, emulsification, nanoprecipitation, solvent extraction, nanoparticle synthesis and functionalization, and emulsion-diffusion/solvent extraction process. All fabricated microfluidics structures can operate in a flow range of mL/min, indicating that LTCC technology provides a means to enhance micro- and nanoparticle production yield.

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Section: Microfluidic Devices For Chemical Process Implementationmentioning

confidence: 53%

Section: Microfluidic Devices For Chemical Process Implementationmentioning

confidence: 99%

Fab on a Package: LTCC Microfluidic Devices Applied to Chemical Process Miniaturization

et al. 2018

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“…Microparticles are generally fabricated by a strategy called droplet-to-particles through different solidification methods, including UV polymerization (Khan et al, 2015a;Liu et al, 2016a;Xue et al, 2015), solvent evaporation (Min et al, 2016), spray drying (Liu et al, 2015a;Liu et al, 2016c;Liu et al, 2012) and ionic cross-linking (Chan et al, 2009;Liu et al, 2016b). In addition to these conventional approaches, which have been widely used to fabricate spherical particles, a number of other ways to make non-spherical polymer microparticles have been developed.…”

Section: Microparticles With Complex Shapesmentioning

confidence: 99%

“…Therefore, this nanoin-micro drug delivery system remained stable in acidic somatic conditions thus prevent any premature release in the gastrointestinal (GI) tract, while the alkaline pH condition in the upper intestinal region triggered the drug release. Instead of using a multistep process by first forming nanoparticles ex situ followed by producing nano-in-micro particles in microfluidic devices, a semi-continuous process was developed for making nano-in-micro Trojan particles combining an elongational-flow micromixer for producing polymerizable nanoemulsions coupled with a co-axial microcapillary for forming microparticles (Khan et al, 2015a).…”

Section: Multifunctional Microparticlesmentioning

confidence: 99%

Multiphase microfluidic synthesis of micro- and nanostructures for pharmaceutical applications

Ran

Sun

Baby

et al. 2017

Chemical Engineering Science

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Multiphase microfluidics has attracted significant interest in making micro-and nanostructures for various applications because of its capabilities in precisely controlling and manipulating a small volume of liquids. In this review, we introduce the recent advances in making micro-and nanostructures for pharmaceutical applications, including microparticles and microcapsules for controlled release, nanoparticles for drug delivery and microgels for 3D cell culture. With the development of more advanced microfluidic systems, the research focus in this field has shifted from making simple micro-and nanostructures to multifunctional systems to achieve more desirable functions. However, these multifunctions may lose their advantages that have been demonstrated in vitro once they are applied in vivo or later in human. The key challenge is a lack of fundamental understanding of the interactions between the micro-and nanomaterials and the biology systems. Consequently, the translation of these advanced materials lags far behind their extensive laboratory research.To better understand the micro-or nano-bio interactions, the development of new in vivomimicking models is imperative. Microfluidics has demonstrated its great potential in creating physiologically relevant models including 3D cell culture, tumor-on-a-chip and organs-on-a-chip. Therefore, efforts towards developing 3D cell culture and biomimetic chips including tumor-on-a-chip and organs-on-chips for faster and reliable evaluation of these micro-and nanosystems are also highlighted.

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“…Одним из решений данной дилеммы является упаковка НЧ в микрочастицы, что позволяет микрочастицам удержаться в альвеолах и высвободить далее НЧ, способные проникать глубже в ткань легких. Такие системы нано-в-микро получили названия «троянских» частиц (Trojan particles, по аналогии с троянским конем) [1][2][3]. «Троянские» частицы предлагаются для доставки лекарств пероральным, трансэпидермальным, ингаляторным или ректальным путем.…”

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Drug micronization technique: new possibilities of topical corticosteroids in dermatology

Matushevskaya¹,

Svirshchevskaya²

2017

Klin. dermatol. venerol.

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С развитием нанотехнологий появилась техническая возможность получать ряд плохо растворимых препаратов в микронизированной и нанонизированной форме, что увеличивает их биодоступность и повышает эффективность. Микронизированные и нанонизированные препараты имеют химические, физические и биологические свойства, существенно отличающиеся от исходного вещества. В фармакологии нано-и микрочастицы чаще всего используют для улучшения их биодоступности при топическом, интраназальном, ректальном и внутриглазном введении. В обзоре приведены результаты зарубежных и отечественных клинических исследований по различным видам микронизации и нанонизации, а также изучению эффективности и безопасности микронизированных лекарственных препаратов в медицине и в дерматологии. Представлены данные о повышении биодоступности глюкокортикостероидных (ГКС) препаратов при использовании микронизации. Показаны преимущества микронизированных ГКС препаратов линии Комфодерм (Комфодерм, Комфодерм М 2 , Комфодерм К) и комбинированных препаратов Акридерм СК и Акридерм ГК в лечении стероид-чувствительных дерматозов.

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Microfluidic conceived Trojan microcarriers for oral delivery of nanoparticles

Cited by 18 publications

References 27 publications

Fab on a Package: LTCC Microfluidic Devices Applied to Chemical Process Miniaturization

Fab on a Package: LTCC Microfluidic Devices Applied to Chemical Process Miniaturization

Multiphase microfluidic synthesis of micro- and nanostructures for pharmaceutical applications

Drug micronization technique: new possibilities of topical corticosteroids in dermatology

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