Microfluidic Control Using Colloidal Devices

Terray, Alex; Oakey, John; Marr, David W. M.

doi:10.1126/science.1072133

Cited by 362 publications

(239 citation statements)

References 26 publications

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“…Our approach to controlling microfluidic droplets relies on all-optical techniques which have been greatly developed in recent years in connection with microfluidic devices [21,22,23,24,25]. Indeed, optical trapping has become a standard tool in biophysics [26] and holographic [22] and generalized phase contrast [25] methods now allow a single laser to be divided into many spots which can be independently manipulated.…”

Section: Generality and Optimizationmentioning

confidence: 99%

An optical toolbox for total control of droplet microfluidics

2007

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The use of microfluidic drops as microreactors hinges on the active control of certain fundamental operations, such as droplet formation, transport, division and fusion. Recent work has demonstrated that local heating from a focused laser can apply a thermocapillary force on a liquid interface sufficient to block the advance of a droplet in a microchannel (Baroud et al., Phys. Rev. E. V 75, p.046302). Here, we demonstrate the usefulness of this optical approach by implementing the operations mentioned above, without the need for any special microfabrication or moving parts. Building blocks such as a droplet valve, sorter, fuser, or divider are shown, as is the combination of a valve and fuser using a single laser spot.

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Section: Generality and Optimizationmentioning

confidence: 99%

An optical toolbox for total control of droplet microfluidics

2007

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“…Not surprisingly, a considerable effort has been invested in the development of microvalves. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] While many of these microvalves are miniaturized versions of their macro, conventional counterparts, some of them are based on unconventional concepts ranging from elastomer, 9,10 hydrogel, 11,12 paraffin, 13,14 and ice valves [15][16][17][18] to colloid valves manipulated by magnetic 8 and electromagnetic 7 fields.…”

Section: Introductionmentioning

confidence: 99%

Thermally-actuated, phase change flow control for microfluidic systems

et al. 2005

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An easy to implement, thermally-actuated, noninvasive method for flow control in microfluidic devices is described. This technique takes advantage of the phase change of the working liquid itself-the freezing and melting of a portion of a liquid slug-to noninvasively close and open flow passages (referred to as a phase change valve). The valve was designed for use in a miniature diagnostic system for detecting pathogens in oral fluids at the point of care. The paper describes the modeling, construction, and characteristics of the valve. The experimental results favorably agree with theoretical predictions. In addition, the paper demonstrates the use of the phase change valves for flow control, sample metering and distribution into multiple analysis paths, sealing of a polymerase chain reaction (PCR) chamber, and sample introduction into and withdrawal from a closed loop. The phase change valve is electronically addressable, does not require any moving parts, introduces only minimal dead volume, is leakage and contamination free, and is biocompatible. CommentsFor personal or professional use only; May not be further made available or distributed.

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“…17,49,61,87,106,110 Alternately, other methods can examine local domains. 20,42,51,54,79,80,102,103,111 Lithographic fabrication techniques have been used to develop tools to study how cell shape is regulated by the attachment and spreading of individual cells. 9,25,55,64,66,67,73,75,92 .…”

Section: Nano-and Microtechnology To Address the Cytoskeletonmentioning

confidence: 99%

Nanoscale Intracellular Organization and Functional Architecture Mediating Cellular Behavior

LeDuc

Bellin

2006

Ann Biomed Eng

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Abstract-Cells function based on a complex set of interactions that control pathways resulting in ultimate cell fates including proliferation, differentiation, and apoptosis. The interworkings of this immensely dense network of intracellular molecules are influenced by more than random protein and nucleic acid distribution where their interactions culminate in distinct cellular function. By probing the design of these biological systems from an engineering perspective, researchers can gain great insight that will aid in building and utilizing systems that are on this size scale where traditional large-scale rules may fail to apply. The organized interaction and gradient distribution in intracellular space imply a structural architecture that modulates cellular processes by influencing biochemical interactions including transport and binding-reactions. One significant structure that plays a role in this modulation is the cell cytoskeleton. Here, we discuss the cytoskeleton as a central and integrating functional structure in influencing cell processes and we describe technology useful for probing this structure. We explain the nanometer scale science of cytoskeletal structure with respect to intracellular organization, mechanotransduction, cytoskeletal-associated proteins, and motor molecules, as well as nano-and microtechnologies that are applicable for experimental studies of the cytoskeleton. This biological architecture of the cytoskeleton influences molecular, cellular, and physiological processes through structured multimodular and hierarchical principles centered on these functional filaments. Through investigating these organic systems that have evolved over billions of years, understanding in biology, engineering, and nanometer-scaled science will be advanced.

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Microfluidic Control Using Colloidal Devices

Cited by 362 publications

References 26 publications

An optical toolbox for total control of droplet microfluidics

An optical toolbox for total control of droplet microfluidics

Thermally-actuated, phase change flow control for microfluidic systems

Nanoscale Intracellular Organization and Functional Architecture Mediating Cellular Behavior

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