Microfluidic Devices and Microfluidics-Integrated Electrochemical and Optical (Bio)Sensors for Pollution Analysis: A Review

Alhalaili, Badriyah; Popescu, Ileana Nicoleta; Rusănescu, Carmen Otilia; Vidu, Ruxandra

doi:10.3390/su141912844

Cited by 13 publications

(5 citation statements)

References 204 publications

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“…As a starting point, the production of microfluidic systems faces many challenges. Although well-established lithography, embodying, and printing systems are extensively utilized for their fabrication, an ideal production scheme would have a better resolution during production, would be cost effective, and would be able to be scaled up for the mass production of necessary components [ 84 ]. In the future, 3D printing will provide the necessary infrastructure for the batch production of microfluidic systems able to detect and characterize MPs [ 85 ].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Microfluidics as a Ray of Hope for Microplastic Pollution

2023

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Microplastic (MP) pollution is rising at an alarming rate, imposing overwhelming problems for the ecosystem. The impact of MPs on life and environmental cycles has already reached a point of no return; yet global awareness of this issue and regulations regarding MP exposure could change this situation in favor of human health. Detection and separation methods for different MPs need to be deployed to achieve the goal of reversing the effect of MPs. Microfluidics is a well-established technology that enables to manipulate samples in microliter volumes in an unprecedented manner. Owing to its low cost, ease of operation, and high efficiency, microfluidics holds immense potential to tackle unmet challenges in MP. In this review, conventional MP detection and separation technologies are comprehensively reviewed, along with state-of-the-art examples of microfluidic platforms. In addition, we herein denote an insight into future directions for microfluidics and how this technology would provide a more efficient solution to potentially eradicate MP pollution.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Microfluidics as a Ray of Hope for Microplastic Pollution

2023

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“…To this end, several detection methods have been proposed to be used in combination with microfluidics in order to provide portable detection devices. Examples of the sensors that have been proposed for the detection of heavy metal ions are the following: electrochemical, fluorescence, colorimetric, (electro)chemiluminescence, piezoresistive, surface plasmon resonance (SPR) and surface-enhanced Raman scattering (SERS) sensors [ 15 , 44 , 45 , 46 , 47 , 48 ]. Figure 3 shows a schematic representation of the different materials and fabrication and detection methods that can be combined for the fabrication of microfluidic devices.…”

Section: Microfluidic and Lab-on-chip Devices For Heavy Metal Ions De...mentioning

confidence: 99%

Microfluidic Devices for Heavy Metal Ions Detection: A Review

Filippidou,

Chatzandroulis

2023

Micromachines

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The contamination of air, water and soil by heavy metal ions is one of the most serious problems plaguing the environment. These metal ions are characterized by a low biodegradability and high chemical stability and can affect humans and animals, causing severe diseases. In addition to the typical analysis methods, i.e., liquid chromatography (LC) or spectrometric methods (i.e., atomic absorption spectroscopy, AAS), there is a need for the development of inexpensive, easy-to-use, sensitive and portable devices for the detection of heavy metal ions at the point of interest. To this direction, microfluidic and lab-on-chip (LOC) devices fabricated with novel materials and scalable microfabrication methods have been proposed as a promising approach to realize such systems. This review focuses on the recent advances of such devices used for the detection of the most important toxic metal ions, namely, lead (Pb), mercury (Hg), arsenic (As), cadmium (Cd) and chromium (Cr) ions. Particular emphasis is given to the materials, the fabrication methods and the detection methods proposed for the realization of such devices in order to provide a complete overview of the existing technology advances as well as the limitations and the challenges that should be addressed in order to improve the commercial uptake of microfluidic and LOC devices in environmental monitoring applications.

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“…The use of micro-and nano-technologies in biology and medicine makes it possible to develop new miniature devices for expressing the control of biological parameters, including multiparametric molecular biomarker monitoring. The main areas of development are biosensors [1,2], lab-on-a-chip (LoC) [3,4] devices and, based on these, portable diagnostic devices in the Point-of-Care Testing (PocT) [5] class. A biosensor is an analytical device that converts a chemical or physical stimulus derived by an interaction with a biological component into a measurable signal.…”

Section: Introductionmentioning

confidence: 99%

Impedimetric Biosensor Coated with Zinc Oxide Nanorods Synthesized by a Modification of the Hydrothermal Method for Antibody Detection

et al. 2023

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Impedimetric biosensors are used for detecting a wide range of analytes. The detection principle is a perspective for the development of new types of analytical devices for biomolecular diagnosis of diseases. Of particular interest are biosensors with very high sensitivities, capable of detecting trace amounts of biomarkers or drugs in biological fluids. Impedimetric biosensors possess a potential for increased sensitivity, since their electrodes can be modified with nanostructured materials, in particular zinc oxide. In this work, a miniature biosensor with an array of zinc oxide nanorods synthesized by the hydrothermal method has been created. Protein A was immobilized on the resulting structure, which was previously tested for binding to omalizumab by capillary electrophoresis. Using impedance spectroscopy, it was possible to detect the binding of omalizumab at concentrations down to 5 pg/mL. The resulting structures are suitable for creating reusable biosensor systems, since ZnO-coated electrodes are easily cleaned by photocatalytic decomposition of the bound molecules. The biosensor is promising for use in Point-of-Care systems designed for fast, multimodal detection of molecular markers of a wide range of diseases.

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Microfluidic Devices and Microfluidics-Integrated Electrochemical and Optical (Bio)Sensors for Pollution Analysis: A Review

Cited by 13 publications

References 204 publications

Microfluidics as a Ray of Hope for Microplastic Pollution

Microfluidics as a Ray of Hope for Microplastic Pollution

Microfluidic Devices for Heavy Metal Ions Detection: A Review

Impedimetric Biosensor Coated with Zinc Oxide Nanorods Synthesized by a Modification of the Hydrothermal Method for Antibody Detection

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