Microfluidic Devices for Biotechnological Applications

Viefhues, Martina; Anselmetti, Dario

doi:10.1016/j.matpr.2017.09.188

Cited by 2 publications

(3 citation statements)

References 13 publications

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“…Table 6 summarizes important parameters, like separation mechanism, separation criteria, molecules, and chip materials for active microfluidic‐based molecular separation methods. [ 19,27,29,31,200–246 ]…”

Section: Microfluidic‐based Separation Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Molecular Separation by Using Active and Passive Microfluidic chip Designs: A Comprehensive Review

Ebrahimi,

Icoz,

Didarian

et al. 2023

Adv Materials Inter

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Separation and identification of molecules and biomolecules such as nucleic acids, proteins, and polysaccharides from complex fluids are known to be important due to unmet needs in various applications. Generally, many different separation techniques, including chromatography, electrophoresis, and magnetophoresis, have been developed to identify the target molecules precisely. However, these techniques are expensive and time consuming. “Lab‐on‐a‐chip” systems with low cost per device, quick analysis capabilities, and minimal sample consumption seem to be ideal candidates for separating particles, cells, blood samples, and molecules. From this perspective, different microfluidic‐based techniques have been extensively developed in the past two decades to separate samples with different origins. In this review, “lab‐on‐a‐chip” methods by passive, active, and hybrid approaches for the separation of biomolecules developed in the past decade are comprehensively discussed. Due to the wide variety in the field, it will be impossible to cover every facet of the subject. Therefore, this review paper covers passive and active methods generally used for biomolecule separation. Then, an investigation of the combined sophisticated methods is highlighted. The spotlight also will be shined on the elegance of separation successes in recent years, and the remainder of the article explores how these permit the development of novel techniques.

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Section: Microfluidic‐based Separation Methodsmentioning

confidence: 99%

“…This study proved that using DEP for DNA manipulation could be useful for sample preparation. Viefhues et al [201,202] also reported an orifice with a DEP microfluidic device to trap and separate DNA strands (Figure 7a). Based on the orifice and DNA characteristics, DNA structures drag and flow through the orifices or become trapped.…”

Section: Dielectrophoresismentioning

confidence: 99%

Molecular Separation by Using Active and Passive Microfluidic chip Designs: A Comprehensive Review

Ebrahimi,

Icoz,

Didarian

et al. 2023

Adv Materials Inter

View full text Add to dashboard Cite

show abstract

“…Chaurey et al used a constriction-based iDEP device integrated with electrically floating electrodes for trapping ssDNA and protein molecules in high-conductivity physiological solutions. Viefhues et al , reported a nanoslit-based DEP device for trapping induced separation of DNA molecules. Depending on the size and DEP characteristics of the DNA molecule, they either get trapped or flow through the nanoslit, leading to separation.…”

Section: Dep Manipulation Of Biological and Non-biological Analytesmentioning

confidence: 99%