Microfluidic Diagnostic Systems for the Rapid Detection and Quantification of Pathogens

Tian, Wei-Chang; Finehout, Erin

doi:10.1007/978-0-387-09480-9_9

Cited by 10 publications

(6 citation statements)

References 227 publications

(258 reference statements)

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“…However, this technique has not yet translated to commercial applications, largely because the forces are very weak in high salt physiologic solutions, while the use of low ionic strength solutions is rather prohibitive in practical applications. In the unique case of red blood cells, which are susceptible to magnetic forces, magnetism has also been used for sample processing in microfluidic devices, though the results do not suggest this method is suitable for highly-efficient separation of erythrocytes [20], [35].…”

Section: Immunoaffinity Techniquesmentioning

confidence: 95%

“…Electrophoresis, the migration of cells or molecules in an externally applied magnetic field, has been applied in microfluidic systems but has limited throughput and may require high voltages [20]. Dielectrophoresis, on the other hand, employs an alternating current (AC) electric field which polarizes particles, resulting in a net force either in the direction or opposite the direction of the electric field.…”

Section: Immunoaffinity Techniquesmentioning

confidence: 99%

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Microfluidics and Nanotechnology for Detection of Global Infectious Diseases

Damhorst

Murtagh²,

Rodriguez

et al. 2015

Proc. IEEE

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| Infectious diseases remain among the world's leading causes of mortality and years of life lost. Significant attention has been paid to the ''Big Three'' infectious pathogensVhuman immunodeficiency virus (HIV), malaria, and tuberculosis (TB)Vbut other conditions such as Chagas' disease, dengue, Ebola, and typhoid, as well as multipathogen processes such as viral hepatitis, pneumonia, and diarrhea, also have major global impact. Addressing these significant disease burdens, which disproportionately impact the world's poorest regions, is a multifaceted grand challenge, requiring new solutions and new technologies. Diagnostics enabled by advances in microfluidics and nanotechnologies can be an important part of the solution. Advantages such as smaller sample size, increased sensitivity, and new multiplexed sensing modalities in a point-of-care format can allow rapid dissemination of test results in remote and resource-limited regions. In this review, we provide a critical assessment of the state-of-the-art in use of these technologies for detection of HIV, malaria, and TB.In addition to discussing opportunities and future prospects, we also discuss the need for additional governmental and nongovernmental funding sources to develop these technologies to their fullest potential, and the need for new business models to enable their commercialization and deployment.

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Section: Immunoaffinity Techniquesmentioning

confidence: 95%

Section: Immunoaffinity Techniquesmentioning

confidence: 99%

Microfluidics and Nanotechnology for Detection of Global Infectious Diseases

Damhorst

Murtagh²,

Rodriguez

et al. 2015

Proc. IEEE

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“…Newly introduced technology is continuously being miniaturized, hence the attractiveness of microfluidic devices. Microfluidic technology was introduced around 20 years ago and is maturing as a technology, despite the initial lack of success on the market [8,9]. The device was influenced from microelectronic chips; however, the use and analysis of fluid movement was changed from the use of pathways for electrons.…”

Section: Microfluidic Technologymentioning

confidence: 99%

Towards the Development of Rapid and Low-Cost Pathogen Detection Systems Using Microfluidic Technology and Optical Image Processing

et al. 2020

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Waterborne pathogens affect all waters globally and proceed to be an ongoing concern. Previous methods for detection of pathogens consist of a high test time and a high sample consumption, but they are very expensive and require specialist operators. This study aims to develop a monitoring system capable of identifying waterborne pathogens with particular characteristics using a microfluidic device, optical imaging and a classification algorithm to provide low-cost and portable solutions. This paper investigates the detection of small size microbeads (1–5 µm) from a measured water sample by using a cost-effective microscopic camera and computational algorithms. Results provide areas of opportunities to decrease sample consumption, reduce testing time and minimize the use of expensive equipment.

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“…A general trend in healthcare towards personalised, remote POCT procedures, and global concerns about emerging diseases are driving substantial investments in microfluidic innovation and rapid market growth in the diagnostics sector. [22][23][24][25][26] As a consequence, point-of-care and microfluidic testing devices are now an essential component of disease control programmes, at the national and global level, from efforts to improve universal health care, to disease elimination campaigns and outbreak response. 27 Until recently there has been little incentive for all actors (researchers, engineers, manufacturers) to develop and use more sustainable and less harmful materials in POCTs and single-use microfluidic devices.…”

Section: Introductionmentioning

confidence: 99%