2024
DOI: 10.1021/acs.langmuir.4c02098
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Microfluidic Dielectrophoretic Purification of Extracellular Vesicles from Plasma Lipoproteins

Jonathan Sabaté del Río,
Yeonzu Son,
Juhee Park
et al.

Abstract: Extracellular vesicles (EVs) are small lipid vesicles shed by cells, carrying proteins, nucleic acids, and other molecular fingerprints. EVs have emerged as crucial mediators of cell-to-cell communication and hold great promise as biomarkers for liquid biopsies, enabling disease screening, diagnosis, prognosis, and monitoring. However, conventional EV separation methods are hampered by the presence of lipoproteins (LPs) in plasma samples, which have comparable characteristics and significantly outnumber EVs. T… Show more

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