Microfluidic equivalents of three logical systems for controlling droplet generation: Set, reset, and set-reset latches

Aminizadeh, Javad; Moosavi, Ali

doi:10.1016/j.sna.2022.114073

Cited by 3 publications

(2 citation statements)

References 60 publications

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“…The droplet generation process depends on the fluid viscosity, flow velocities, wetting properties, and geometric features, and it can be classified into passive and active droplet generation [ 44 , 45 ]. Passive droplet generation methods rely on pressure-driven flow and channel geometry, whereas active droplet generation requires external aid from several active control sources [ 46 , 47 ]. Active methods have many advantages over passive methods, including high control of the droplet size and a short droplet generation time [ 48 , 49 , 50 ].…”

Section: Droplet-based Microfluidicsmentioning

confidence: 99%

Droplet-Based Microfluidics: Applications in Pharmaceuticals

Trinh,

Do,

Nam

et al. 2023

Pharmaceuticals

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Droplet-based microfluidics offer great opportunities for applications in various fields, such as diagnostics, food sciences, and drug discovery. A droplet provides an isolated environment for performing a single reaction within a microscale-volume sample, allowing for a fast reaction with a high sensitivity, high throughput, and low risk of cross-contamination. Owing to several remarkable features, droplet-based microfluidic techniques have been intensively studied. In this review, we discuss the impact of droplet microfluidics, particularly focusing on drug screening and development. In addition, we surveyed various methods of device fabrication and droplet generation/manipulation. We further highlight some promising studies covering drug synthesis and delivery that were updated within the last 5 years. This review provides researchers with a quick guide that includes the most up-to-date and relevant information on the latest scientific findings on the development of droplet-based microfluidics in the pharmaceutical field.

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Section: Droplet-based Microfluidicsmentioning

confidence: 99%

Droplet-Based Microfluidics: Applications in Pharmaceuticals

Trinh,

Do,

Nam

et al. 2023

Pharmaceuticals

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“…Understanding droplet behavior in a confined environment is crucial for the design of various micromixing devices. Design developments in soft robotics, quake valves, lab-on-a-chip, microelectronics, and organ-on-a-chip require knowledge of droplet dynamics. − …”

Section: Introductionmentioning

confidence: 99%

Velocity Field within Droplets Falling in Liquid Media inside a Rectangular Channel

Mishra,

Gupta,

Singh

2024

Ind. Eng. Chem. Res.

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The concept of droplet microfluidics and droplet reactors is becoming popular in the chemical processing industry, especially to handle expensive specialty chemicals. The convective mixing within a single droplet or two coalescing droplets plays an important role during the reaction involving two-phase systems, which requires a good understanding of the internal fluid motion within the droplet. In this work, we study the flow field inside a liquid droplet falling through an immiscible liquid in a narrow-width rectangular vertical channel using particle image velocimetry (PIV). The droplet can be considered a representation of a midplane cutting through a spherical droplet. The effect of the size and release position of the droplet on the velocity field is examined. When the droplet is released at the center of the channel, a pair of symmetric counter-rotating vortices is observed inside the droplet. The vortices are positioned in the bottom half of the droplet and move toward its horizontal centerline as the diameter increases. However, when the droplet is released at an off-center position, the vortices are not symmetric. The terminal velocity of the droplet is observed to increase with an increase in droplet diameter, and therefore, coalescence occurs when a bigger droplet is released following a smaller one. The growth of the neck of the combined droplet with time and the velocity field at the neck are studied during coalescence.

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Numerical simulation study of bubble breakup mechanism in microchannels with V-shaped obstacle

Han,

Wang,

et al. 2024

Chemical Engineering and Processing - Process Intensification

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Microfluidic equivalents of three logical systems for controlling droplet generation: Set, reset, and set-reset latches

Cited by 3 publications

References 60 publications

Droplet-Based Microfluidics: Applications in Pharmaceuticals

Droplet-Based Microfluidics: Applications in Pharmaceuticals

Velocity Field within Droplets Falling in Liquid Media inside a Rectangular Channel

Numerical simulation study of bubble breakup mechanism in microchannels with V-shaped obstacle

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