Microfluidic Magnetic Mixing at Low Reynolds Numbers and in Stagnant Fluids

Shanko, Eriola-Sophia; Burgt, Yoeri van de; Anderson, Patrick Patrick; Toonder, Jaap M.J. den

doi:10.3390/mi10110731

Cited by 82 publications

(53 citation statements)

References 136 publications

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“…In LOC devices, the rapid mixing of fluids is necessary to confirm homogenous composition for an efficient reaction with low inconsistency [77]. Mixing of fluids can take place in a laminar flow or a static method, but trying on micrometer scale because of small Reynolds number [169]. Magnetic NP scans can be utilized to mix fluids in a LOC system and have also been for microfluidic mixing.…”

Section: Applicationsmentioning

confidence: 99%

Magnetic nanoparticles in microfluidic and sensing: From transport to detection

et al. 2020

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Superparamagnetic nanoparticles are attracting significant attention. Therefore, being explored in microsystems for a wide range of applications. Typical examples include labon-a-chip and microfluidics for synthesis, detection, separation, and transportation of different bioanalytes, such as biomolecules, cells, and viruses to develop portable, sensitive, and cost-effective biosensing systems. Particularly, microfluidic systems incorporated with magnetic nanoparticles and, in combination with magnetoresistive sensors, shift diagnostic and analytical methods to a microscale level. In this context, nanotechnology enables the miniaturization and integration of a variety of analytical functions in a single chip for manipulation, detection, and recognition of bioanalytes reliably and flexibly. In consideration of the above, recent development and benefits are elaborated herein to discuss the role of magnetic nanoparticles inside the microchannels to design highly efficient disposable point-of-care applications from transportation to the detection of bioanalytes.

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Section: Applicationsmentioning

confidence: 99%

Magnetic nanoparticles in microfluidic and sensing: From transport to detection

et al. 2020

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“…This microfluidic design embedded along with a gold-patterned microarray chamber for sandwich complex-based sensing achieved automated detection of multiple clinical biomarkers within 60 minutes. Another method of mixing within microfluidic devices has been realized by the use of magnetism and magnetic beads [118]. By using a rotating magnetic disk and magnetic beads in solution it is possible to create chaotic fluid flow, thereby achieving mixing between various solutions.…”

Section: How To Detect On-sitementioning

confidence: 99%

“…As previously mentioned, environmental water samples are complex and thus require filtration prior to further preparation steps and detection. Multiple filtration steps may be required, ranging from the removal of macroparticles such as microplastics and humic material to removal of Another method of mixing within microfluidic devices has been realized by the use of magnetism and magnetic beads [118]. By using a rotating magnetic disk and magnetic beads in solution it is possible to create chaotic fluid flow, thereby achieving mixing between various solutions.…”

Section: How To Detect On-sitementioning

confidence: 99%

“…Using this method, it was shown that sufficient sample mixing can be achieved within relatively short distances over 5 minutes at a linear velocity of 0.19 mm/s [119]. Another method of mixing within microfluidic devices has been realized by the use of magnetism and magnetic beads [118]. By using a rotating magnetic disk and magnetic beads in solution it is possible to create chaotic fluid flow, thereby achieving mixing between various solutions.…”

Section: How To Detect On-sitementioning

confidence: 99%

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Integrated Electrochemical Biosensors for Detection of Waterborne Pathogens in Low-Resource Settings

et al. 2020

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More than 783 million people worldwide are currently without access to clean and safe water. Approximately 1 in 5 cases of mortality due to waterborne diseases involve children, and over 1.5 million cases of waterborne disease occur every year. In the developing world, this makes waterborne diseases the second highest cause of mortality. Such cases of waterborne disease are thought to be caused by poor sanitation, water infrastructure, public knowledge, and lack of suitable water monitoring systems. Conventional laboratory-based techniques are inadequate for effective on-site water quality monitoring purposes. This is due to their need for excessive equipment, operational complexity, lack of affordability, and long sample collection to data analysis times. In this review, we discuss the conventional techniques used in modern-day water quality testing. We discuss the future challenges of water quality testing in the developing world and how conventional techniques fall short of these challenges. Finally, we discuss the development of electrochemical biosensors and current research on the integration of these devices with microfluidic components to develop truly integrated, portable, simple to use and cost-effective devices for use by local environmental agencies, NGOs, and local communities in low-resource settings.

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“…For instance, magnetic force induced mixing usually requires utilization of ferrofluid [22] to create disturbance inside the fluidics system, which is undesirable especially for DNA purification process [23,24]. Furthermore, additional actuating mechanisms employing i.e., magnetic beads or magnetic artificial cilia [25] increases system complexity. Active micromixers utilizing ultrasound and thermal energy have been demonstrated effective to enhance micromixing process.…”

Section: Introductionmentioning

confidence: 99%

Effect of Thermal Energy and Ultrasonication on Mixing Efficiency in Passive Micromixers

et al. 2021

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Micromixing is a key process in microfluidics technology. However, rapid and efficient fluid mixing is difficult to achieve inside the microchannels due to unfavourable laminar flow. Active micromixers employing ultrasound and thermal energy are effective in enhancing the micromixing process; however, integration of these energy sources within the devices is a non-trivial task. In this study, ultrasound and thermal energy have been extraneously applied at the upstream of the micromixer to significantly reduce fabrication complexity. A novel Dean micromixer was laser-fabricated to passively increase mixing performance and compared with T- and Y-micromixers at Reynolds numbers between 5 to 100. The micromixers had a relatively higher mixing index at lower Reynolds number, attributed to higher residence time. Dean micromixer exhibits higher mixing performance (about 27% better) than T- and Y-micromixers for 40 ≤ Re ≤ 100. Influence of ultrasound and heat on mixing is more significant at 5 ≤ Re ≤ 20 due to the prolonged mechanical effects. It can be observed that mixing index increases by about 6% to 10% once the temperature of the sonicated fluids increases from 30 °C to 60 °C. The proposed method is potentially useful as direct contact of the inductive energy sources may cause unwanted substrate damage and structural deformation especially for applications in biological analysis and chemical synthesis.

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Microfluidic Magnetic Mixing at Low Reynolds Numbers and in Stagnant Fluids

Cited by 82 publications

References 136 publications

Magnetic nanoparticles in microfluidic and sensing: From transport to detection

Magnetic nanoparticles in microfluidic and sensing: From transport to detection

Integrated Electrochemical Biosensors for Detection of Waterborne Pathogens in Low-Resource Settings

Effect of Thermal Energy and Ultrasonication on Mixing Efficiency in Passive Micromixers

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