Microfluidic microsystem for magnetic sensing of nanoparticles with Giant Magneto-Impedance technology

Denoual, Matthieu; Harnois, Maxime; Saez, Sébastien; Dolabdjian, Christophe; Senez, V.

doi:10.1109/transducers.2011.5969140

Cited by 5 publications

(5 citation statements)

References 7 publications

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“…As expected, it is possible to verify that the sensitivity obtained by equation ( 15) is satisfactorily close to that pre viously calculated by equation (11). Besides 100 Hz, it is possible to observe the presence of other significant spectral components in figure 16.…”

Section: Frequency Responsesupporting

confidence: 82%

“…The impedance Z sens (H) of the GMI sample can be modeled as a resistance (R sens (H)) in series with an inductance (L sens (H)) [1,4,[10][11][12] according to…”

Section: Electrical Model Of the Gmi Samplementioning

confidence: 99%

“…where 52.8 • 10 3 V T −1 is the experimental sensitivity of the circuit for DC fields, as per equation (11).…”

Section: Frequency Responsementioning

confidence: 99%

“…Recent studies have shown that pressure transducers based on GMI sensors, deposited on flexible substrates, present high performance and can be used for pressure measurements in microfluidic chambers and biomedical applications [11][12][13]. In a previous work, a pressure transducer was implemented…”

Section: Introductionmentioning

confidence: 99%

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High sensitivity pressure transducer based on the phase characteristics of GMI magnetic sensors

Benavides

Silva

Monteiro

et al. 2018

Meas. Sci. Technol.

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This paper presents a new configuration for a GMI pressure transducer based on the reading of the phase characteristics of GMI sensor, intended for biomedical applications. The development process of this new class of magnetic field transducers is discussed, beginning with the definition of the ideal conditioning of the GMI sensor elements (dc level and frequency of the excitation current and sample length) and continuing with computational simulations of the full electronic circuit performed using the experimental data obtained from measured GMI curves, and have shown that the improvement in the sensitivity of GMI magnetometers is larger when phase-based transducers are used instead of magnitude-based transducers. Parameters of interest of the developed prototype are thoroughly analyzed, such as: sensitivity, linearity and frequency response. Also, the spectral noise density of the developed pressure transducer is evaluated and its resolution in the passband is estimated. A low-cost GMI pressure transducer was developed, presenting high resolution, high sensitivity and a frequency bandwidth compatible to the desired biomedical applications.

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Section: Frequency Responsesupporting

confidence: 82%

“…The impedance Z sens (H) of the GMI sample can be modeled as a resistance (R sens (H)) in series with an inductance (L sens (H)) [1,4,[10][11][12] according to…”

Section: Electrical Model Of the Gmi Samplementioning

confidence: 99%

“…where 52.8 • 10 3 V T −1 is the experimental sensitivity of the circuit for DC fields, as per equation (11).…”

Section: Frequency Responsementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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High sensitivity pressure transducer based on the phase characteristics of GMI magnetic sensors

Benavides

Silva

Monteiro

et al. 2018

Meas. Sci. Technol.

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“…Ferrofluid has been widely used as a magnetic material for testing the performance of magnetic sensors [9,11,13,[15][16][17]. Most of the signals from ferrofluids are weak and respond to slow flowing with the exception of one group [15], who has simulated the shape of magnetic signal of ferrofluid.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Sensor-Based Detection of Picoliter Volumes of Magnetic Nanoparticle Droplets in a Microfluidic Chip

Jeong¹,

Eu²,

Kim³

et al. 2012

Journal of Magnetics

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We have designed, fabricated and tested an integrated microfluidic chip with a Planar Hall Effect (PHE) sensor. The sensor was constructed by sequentially sputtering Ta/NiFe/Cu/NiFe/IrMn/Ta onto glass. The microfluidic channel was fabricated with poly(dimethylsiloxane) (PDMS) using soft lithography. Magnetic nanoparticles suspended in hexadecane were used as ferrofluid, of which the saturation magnetisation was 3.4 emu/cc. Droplets of ferrofluid were generated in a T-junction of a microfluidic channel after hydrophilic modification of the PDMS. The size and interval of the droplets were regulated by pressure on the ferrofluid channel inlet. The PHE sensor detected the flowing droplets of ferrofluid, as expected from simulation results. The shape of the signal was dependent on both the distance of the magnetic droplet from the sensor and the droplet length. The sensor was able to detect a magnetic moment of 2 × 10 −10 emu at a distance of 10 µm. This study provides an enhanced understanding of the magnetic parameters of ferrofluid in a microfluidic channel using a PHE sensor and will be used for a sample inlet module inside of integrated magnetic lab-on-a-chip systems for the analysis of biomolecules.

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Sensing Magnetic Nanoparticles

2019

Magnetic Nanoparticles in Biosensing and Medicine

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Microfluidic microsystem for magnetic sensing of nanoparticles with Giant Magneto-Impedance technology

Cited by 5 publications

References 7 publications

High sensitivity pressure transducer based on the phase characteristics of GMI magnetic sensors

High sensitivity pressure transducer based on the phase characteristics of GMI magnetic sensors

Magnetic Sensor-Based Detection of Picoliter Volumes of Magnetic Nanoparticle Droplets in a Microfluidic Chip

Sensing Magnetic Nanoparticles

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