Microfluidic paper-based analytical devices for cancer diagnosis

Shalaby, Ahmed A.; Tsao, Chia Wen; Ishida, Akihiko; Maeki, Masatoshi; Tokeshi, Manabu

doi:10.1016/j.snb.2022.133243

Cited by 21 publications

(10 citation statements)

References 217 publications

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“…Biomarkers can easily produce color changes, enabling earlier disease identification and self-monitoring for cancers. 23 Liquid biopsy diagnostics now use parallel electrochemical assays, which have increased sensitivity and specificity for detecting biomarkers in low concentrations. Portable electrochemical units enable point-of-care testing and disease progress monitoring over time.…”

Section: ■ Overview Of Fabrication Methodsmentioning

confidence: 99%

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Paper-Based Analytical Devices for Cancer Liquid Biopsy

Singh,

Raucci,

Cimmino

et al. 2024

Anal. Chem.

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Liquid biopsies have caused a significant revolution in cancer diagnosis, and the use of point of care (PoC) platforms has the potential to bring liquid biopsy-based cancer detection closer to patients. These platforms provide rapid and on-site analysis by reducing the time between sample collection and results output. The aim of this tutorial content is to provide readers an in-depth understanding regarding the choice of the ideal sensing platform suitable for specific cancer-related biomarkers.

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Section: ■ Overview Of Fabrication Methodsmentioning

confidence: 99%

“…Diagnostic possibilities and PoC testing are feasible in limited resource settings. Biomarkers can easily produce color changes, enabling earlier disease identification and self-monitoring for cancers …”

Section: Overview Of Fabrication Methodsmentioning

confidence: 99%

Paper-Based Analytical Devices for Cancer Liquid Biopsy

Singh,

Raucci,

Cimmino

et al. 2024

Anal. Chem.

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“…However, challenges related to achieving optimal loading and distribution of imaging agents persist. [69][70][71] The integration of ATRP and RAFT with microfluidics has facilitated the creation of stimuli-responsive nanogels. These materials can adapt to changes in their environment, offering potential applications in smart coatings, sensors, and actuators.…”

Section: Recent Advances and Applications: Chemistry At Workmentioning

confidence: 99%

“…T A B L E 5 Representation of possible applications with specific features. [60][61][62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78]…”

Section: Recent Advances and Applications: Chemistry At Workmentioning

confidence: 99%

Controlled polymerization in microfluidics: Advancement in nanogel synthesis

Pandey,

Sharma,

Sandhu

et al. 2023

SPE Polymers

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This comprehensive review provides a detailed examination of controlled polymerization in the development of nanogels‐based microfluidic devices. Here, we have explored the integration of atom transfer radical polymerization (ATRP) and reversible addition‐fragmentation chain transfer (RAFT) techniques within microfluidic platforms for the synthesis of nanogels. The synergistic combination of ATRP and RAFT with microfluidics has emerged as a powerful tool for precise control over polymerization reactions, enabling the fabrication of well‐defined, multifunctional nanogels with tailored properties. The review begins with a thorough introduction to the principles of ATRP and RAFT, highlighting their respective advantages in controlled radical polymerization. Subsequently, it elucidates the principles of microfluidics and its profound impact on polymerization processes. The merging of these techniques enables precise control over reaction kinetics, monomer conversions, and molecular weight distributions, facilitating the synthesis of nanogels with unprecedented precision and reproducibility. Furthermore, this review delves into the chemical mechanisms underlying ATRP and RAFT reactions in microfluidic environments, emphasizing the role of various initiators, catalysts, and chain transfer agents. Special attention is given to the impact of microscale flow conditions on reaction kinetics and polymer structure. In addition, the review discusses emerging trends in the field, such as the incorporation of novel monomers and the exploration of environmentally benign reaction conditions.Highlights The controlled polymerization is the mechanism by which we can obtain tailormade material. The nanogel synthesis must ensure the gelation to be in confined dimensions here microfluidics plays key role.

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“…Microfluidic biosensors and cancer biomarkers have been the focus of many recent papers. There are reviews centered around many topics such as electrochemistry, electrochemiluminescence, commercialization, manufacturing techniques, and microfluidic chips [ 7 , 8 , 9 , 10 ]. As a departure from the overview of paper-based biosensors provided by existing articles, we have reviewed studies in the field of microfluidic paper-based biosensors and discussed their contribution to public health by addressing their relevance to POC, point-of-need (PON), and telemedicine.…”

Section: Introductionmentioning

confidence: 99%

Biomarker Detection in Early Diagnosis of Cancer: Recent Achievements in Point-of-Care Devices Based on Paper Microfluidics

et al. 2023

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Microfluidics is very crucial in lab-on-a-chip systems for carrying out operations in a large-scale laboratory environment on a single chip. Microfluidic systems are miniaturized devices in which the fluid behavior and control can be manipulated on a small platform, with surface forces on the platform being greater than volumetric forces depending on the test method used. In recent years, paper-based microfluidic analytical devices (μPADs) have been developed to be used in point-of-care (POC) technologies. μPADs have numerous advantages, including ease of use, low cost, capillary action liquid transfer without the need for power, the ability to store reagents in active form in the fiber network, and the capability to perform multiple tests using various measurement techniques. These benefits are critical in the advancement of paper-based microfluidics in the fields of disease diagnosis, drug application, and environment and food safety. Cancer is one of the most critical diseases for early detection all around the world. Detecting cancer-specific biomarkers provides significant data for both early diagnosis and controlling the disease progression. μPADs for cancer biomarker detection hold great promise for improving cure rates, quality of life, and minimizing treatment costs. Although various types of bioanalytical platforms are available for the detection of cancer biomarkers, there are limited studies and critical reviews on paper-based microfluidic platforms in the literature. Hence, this article aims to draw attention to these gaps in the literature as well as the features that future platforms should have.

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Microfluidic paper-based analytical devices for cancer diagnosis

Cited by 21 publications

References 217 publications

Paper-Based Analytical Devices for Cancer Liquid Biopsy

Paper-Based Analytical Devices for Cancer Liquid Biopsy

Controlled polymerization in microfluidics: Advancement in nanogel synthesis

Biomarker Detection in Early Diagnosis of Cancer: Recent Achievements in Point-of-Care Devices Based on Paper Microfluidics

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