Microfluidic Pneumatic Printed Sandwiched Microdroplet Array for High-Throughput Enzymatic Reaction and Screening

A liquid metal based, integrated parallel electroosmotic micropump cluster drive system

“…11 Through PDMS-based soft lithography technology, combined with PDMS surface treatment for multilayer bonding, 12 3D chip fabrication can be realized, and microfluidic chips that meet different structural and functional requirements can be fabricated. [13][14][15] At the same time, making full use of the advantages of micromachining, the room-temperature liquid metal (LM, such as gallium-based alloy) is directly injected into the microchannel to form electrodes, [16][17][18][19] which greatly reduces the complexity of electrode fabrication compared with traditional processes such as sputtering, combined with other advantages, such as high flexibility, deformability, electrical conductivity, thermal conductivity and nontoxicity. [20][21][22][23] In addition, a study has shown that the reversible bonding process of polycarbonate (PC) and PDMS can be used to fabricate complex blind ends and contact liquid metal microelectrodes.…”

Precision enhanced alignment bonding technique with sacrificial strategy

“…Since the late 1990’s, microfluidics has gradually developed from Micro Electromechanical System (MEMS) technology and become an independent interdisciplinary research field ( Whitesides, 2006 ; Fan et al, 2018 ). In recent years, microfluidics has been widely applied in bio (chemical) analysis ( Zheng et al, 2004 ), drug screening ( Sun et al, 2020 ), cell handing ( Zilionis et al, 2017 ), organ-on-a-chip engineering ( Huh et al, 2010 ; Cheng et al, 2017 ), nanomaterial preparation ( Yu et al, 2017 ) and other specific fields. By manufacturing complex multi-channel three-dimensional structures, microfluidic chips can achieve more complex functions ( Sharma et al, 2015 ).…”

Controllable Preparation of Monodisperse Chitosan Microspheres Based on Microfluidic Technology

“…Microfluidic technology is an emerging technology that can process and manipulate tiny amounts of fluids in micrometer-scale spaces. , After 30 years of rapid development, microfluidic technology is gradually intersecting with other disciplines, including physics, chemistry, biology, medicine, engineering, and other fields. Because of the uniform and controllable size of the generated droplets, microfluidics is widely used in detection and diagnosis, − single-cell analysis, high-throughput screening, − drug development, , and the manufacture of functional particles. Current education articles on microfluidics mainly introduce continuous microfluidics, − while there are few educational articles on droplet microfluidics. , Continuous microfluidics is based on the control of continuous flow in microchannels.…”