Microfluidic separation processes using the thermodiffusion effect

Martin‐Mayor, Alain; Bou-Ali, M. Mounir; Aginagalde, Maialen; Urteaga, Pedro

doi:10.1016/j.ijthermalsci.2017.10.024

Cited by 18 publications

(16 citation statements)

References 53 publications

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“…An example of this geometry will discussed in detail in Section 5.1.1 . A thermogravitational micro column (TG

C) configuration is displayed in Figure 1 b. Herein, the gravitational field is perpendicular to the temperature gradient, so that the convective flow enhances the separation of the components [ 41 , 47 , 58 ]. The design details of a TG

C will discussed in Section 5.1.1 .…”

Section: How To Generate Temperature Gradientsmentioning

confidence: 99%

“…If the dimensions and thermophysical properties are known the temperature profile between the cold and hot channel can be estimated. The micron-scale devices using channels do not require clean-room facilities, as it is required for lithographical fabrication on nano-size wires and has been realized in various labs [ 41 , 43 , 45 , 47 , 55 , 56 , 58 , 59 , 61 ].…”

Section: How To Generate Temperature Gradientsmentioning

confidence: 99%

“…In the majority of the devices [ 41 , 43 , 45 , 47 , 55 , 56 , 58 , 59 ], water is directly used as thermostating fluid or as heat sink fluid, if Peltier elements are used [ 61 ]. So far, the operating temperatures are located in the liquid state of water.…”

Section: How To Generate Temperature Gradientsmentioning

confidence: 99%

“…A material with a high thermal conductivity (

W/mK) should be preferred in order to reduce the temperature change across the gap. For this reason, materials such as copper (

W/mK), sapphire (

W/mK) [ 41 , 47 , 55 , 56 ], aluminum (

W/mK) [ 58 ] and stainless steel (

W/mK) [ 43 , 45 , 59 ] are used. However, except for sapphire, most materials with a high thermal conductivity are not transparent for visible light and, therefore, they are not suitable for optical detection.…”

Section: How To Generate Temperature Gradientsmentioning

confidence: 99%

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Thermophoretic Micron-Scale Devices: Practical Approach and Review

Lee

Wiegand

2020

Entropy

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In recent years, there has been increasing interest in the development of micron-scale devices utilizing thermal gradients to manipulate molecules and colloids, and to measure their thermophoretic properties quantitatively. Various devices have been realized, such as on-chip implements, micro-thermogravitational columns and other micron-scale thermophoretic cells. The advantage of the miniaturized devices lies in the reduced sample volume. Often, a direct observation of particles using various microscopic techniques is possible. On the other hand, the small dimensions lead to some technical problems, such as a precise temperature measurement on small length scale with high spatial resolution. In this review, we will focus on the “state of the art” thermophoretic micron-scale devices, covering various aspects such as generating temperature gradients, temperature measurement, and the analysis of the current micron-scale devices. We want to give researchers an orientation for their development of thermophoretic micron-scale devices for biological, chemical, analytical, and medical applications.

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“…An example of this geometry will discussed in detail in Section 5.1.1 . A thermogravitational micro column (TG

C will discussed in Section 5.1.1 .…”

Section: How To Generate Temperature Gradientsmentioning

confidence: 99%

Section: How To Generate Temperature Gradientsmentioning

confidence: 99%

Section: How To Generate Temperature Gradientsmentioning

confidence: 99%

“…A material with a high thermal conductivity (

W/mK) should be preferred in order to reduce the temperature change across the gap. For this reason, materials such as copper (

W/mK), sapphire (

W/mK) [ 41 , 47 , 55 , 56 ], aluminum (

W/mK) [ 58 ] and stainless steel (

Section: How To Generate Temperature Gradientsmentioning

confidence: 99%

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Thermophoretic Micron-Scale Devices: Practical Approach and Review

Lee

Wiegand

2020

Entropy

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“…The authors show that it is possible to quantify and to optimize the species separation for ternary mixtures. In a recent paper published by Alain Martin et al (2018), the separation process was analyzed both numerically and experimentally in a mixture of dimethyl sulfoxide in phosphate buffered saline. Their results confirm that the effect of thermodiffusion must be considered to hand processes of biological fluid mixtures because the existence of a thermal gradient could improve the efficiency of the separation process in micro devices.…”

Section: Introductionmentioning

confidence: 99%

On the Optimization of the Species Separation in an Inclined Darcy-Brinkman Porous Cavity under the Effect of an External Magnetic Field

Hasnaoui¹,

Abdelkhalek²

2018

JAFM

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An investigation is conducted to study analytically and numerically the effect of a magnetic field on the species separation induced by the combined effects of convection and Soret phenomenon in an inclined porous cavity saturated by an electrically conductive binary mixture and provided with four impermeable walls. The long sides of the cavity are subject to uniform heat flux while its short ends are adiabatic. Uniform magnetic field is applied perpendicularly to the heated walls. The mixture satisfies the Boussinesq approximation and the porous medium, modeled according to Darcy-Brinkman's law, is assumed homogeneous and isotropic .The relevant parameters for the problem are the thermal Rayleigh number (RT = 1 to 10 6 ), the Lewis number (Le = 10), the inclination angle of the cavity (θ = 0º to 180), the separation parameter (φ = 0.5), the Darcy number (Da = 10 -5 to 10 3 ), the Hartmann number (Ha = 0 to 100) and the aspect ratio of the cavity (Ar = 12). The limiting cases (Darcy and pure fluid media) are recovered in this study. Optimum conditions leading to maximum separation of species are determined while varying the governing parameters in their respective ranges. Results show that the magnetic field can enhance the species separation in cases where the optimal coupling between thermosolutal diffusion and convection is not achieved in its absence. On the other hand, in cases where this optimal coupling is reached in the absence of the magnetic field, the application of the latter destroys the separation of species.

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Molecular Separation by Using Active and Passive Microfluidic chip Designs: A Comprehensive Review

Ebrahimi,

Icoz,

Didarian

et al. 2023

Adv Materials Inter

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Separation and identification of molecules and biomolecules such as nucleic acids, proteins, and polysaccharides from complex fluids are known to be important due to unmet needs in various applications. Generally, many different separation techniques, including chromatography, electrophoresis, and magnetophoresis, have been developed to identify the target molecules precisely. However, these techniques are expensive and time consuming. “Lab‐on‐a‐chip” systems with low cost per device, quick analysis capabilities, and minimal sample consumption seem to be ideal candidates for separating particles, cells, blood samples, and molecules. From this perspective, different microfluidic‐based techniques have been extensively developed in the past two decades to separate samples with different origins. In this review, “lab‐on‐a‐chip” methods by passive, active, and hybrid approaches for the separation of biomolecules developed in the past decade are comprehensively discussed. Due to the wide variety in the field, it will be impossible to cover every facet of the subject. Therefore, this review paper covers passive and active methods generally used for biomolecule separation. Then, an investigation of the combined sophisticated methods is highlighted. The spotlight also will be shined on the elegance of separation successes in recent years, and the remainder of the article explores how these permit the development of novel techniques.

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Microfluidic separation processes using the thermodiffusion effect

Cited by 18 publications

References 53 publications

Thermophoretic Micron-Scale Devices: Practical Approach and Review

Thermophoretic Micron-Scale Devices: Practical Approach and Review

On the Optimization of the Species Separation in an Inclined Darcy-Brinkman Porous Cavity under the Effect of an External Magnetic Field

Molecular Separation by Using Active and Passive Microfluidic chip Designs: A Comprehensive Review

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