2015
DOI: 10.1039/c4ra11438h
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Microfluidic spinning of fibrous alginate carrier having highly enhanced drug loading capability and delayed release profile

Abstract: Natural polymer-based drug carriers have been developed for antimicrobial applications but several problems remain with their poor controllability of drug loading and degradation. We introduce a novel method to produce improved antibiotic alginate fiber with high drug entrapment properties and a delayed degradation profile. A microfluidic spinning system with a low-polarity isopropyl alcohol (IPA) sheath flow was used to dehydrate an alginate/ampicillin aqueous solution and to form densely packed fiber with en… Show more

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Cited by 58 publications
(48 citation statements)
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“…After a fixed time interval, the alginate fibers were taken out and dried in an oven at 60 °C, then weighed under ambient conditions. The degradation degree of fibers is represented by the mass loss and then calculates with the formula Mass loss()%=W0W1W0×100% where W 0 is the initial weight of fiber, and W 1 denotes the weight of the degradative fiber.…”
Section: Methodsmentioning
confidence: 99%
“…After a fixed time interval, the alginate fibers were taken out and dried in an oven at 60 °C, then weighed under ambient conditions. The degradation degree of fibers is represented by the mass loss and then calculates with the formula Mass loss()%=W0W1W0×100% where W 0 is the initial weight of fiber, and W 1 denotes the weight of the degradative fiber.…”
Section: Methodsmentioning
confidence: 99%
“…Microfibers of calcium alginate, a biocompatible hydrogel material, are widely used for several biomedical applications such as wound healing, 1,2,3 and cell encapsulation. 4 These fibers are also commonly used for making complex fibrous networks, such as 3D scaffolds used in tissue engineering.…”
Section: Introductionmentioning
confidence: 99%
“…[1][2][3][4] These outstanding properties make the polymer bers optimal candidates for many important applications such as tissue engineering, cell encapsulation, wound dressings, and drug release. [5][6][7][8][9] Several different ber fabrication approaches exist such as microuidic, electrospinning, and wet spinning. 10,11 Micro-uidics is an emerging approach that uses small amount of samples for a wide range of applications from biomedical systems to energy devices.…”
Section: Introductionmentioning
confidence: 99%