Microfluidic synthesis of fluorescent magnetonanoparticles and characterization

Abstract

This study presents a stable and controllable synthesis of the fluorescent magnetic nanoparticles in a flow-through microchannel. La Mer process is carried out to synthesize the magnetic nanoparticles using co-precipitation. Then, the magnetic nanoparticles are coated with conjugation of chitosan and fluorescent isothiocianate. The chemical composition of the magnetic nanoparticles and their sizes are determined. The magnetic property of saturation magnetization and coercive field is characterized. Also, the possibility of external manipulation by separating the synthesized fluorescent magnetic nanoparticles into non-reacting lamination flow is demonstrated. Finally, their fluorescence property is determined.

Microfluidic Synthesis of Iron Oxide Nanoparticles

“…A number of studies have been performed on microfluidic devices manufactured using PDMS [ 66 ], PTFE [ 67 ], and PMMA [ 52 ]. IONPs produced in these microfluidic devices exhibited core sizes of 35 nm for the PDMS-based device and a core size range of 12.3 to 24.6 nm in the PTFE-based device [ 66 , 67 ]. Another study used PTFE, silicone, and glass capillaries to manufacture a tubular microfluidic device with channel diameters of 400 µm for the glass capillaries and 820 µm for the PTFE and 3600 µm for the silicone tubing [ 68 ].…”