Microfluidic synthesis of magnetic nanoparticles in droplet-based microreactors

Zou, Lei; Huang, Bo; Zheng, Xinqian; Pan, Hailin; Zhang, Qing; Xie, Wenhui; Zhao, Zhenjie; Li, Xin

doi:10.1016/j.matchemphys.2021.125384

Cited by 27 publications

(12 citation statements)

References 47 publications

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“…Moreover, the configuration and arrangement of microchannels in specific patterns allow for optimal mixing and reaction time, making geometry a key player in the device’s efficiency. For instance, a droplet-based microreactor was employed to study the effect of different flow rates on the properties of magnetic NPs . The device presented different patterns that work as multifunctional units (T-junction, Y-junction, and S-channels).…”

Section: Microfluidic Devicesmentioning

confidence: 99%

Microfluidic Devices: A Tool for Nanoparticle Synthesis and Performance Evaluation

Gimondi,

Ferreira,

Reis

et al. 2023

ACS Nano

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The use of nanoparticles (NPs) in nanomedicine holds great promise for the treatment of diseases for which conventional therapies present serious limitations. Additionally, NPs can drastically improve early diagnosis and follow-up of many disorders. However, to harness their full capabilities, they must be precisely designed, produced, and tested in relevant models. Microfluidic systems can simulate dynamic fluid flows, gradients, specific microenvironments, and multiorgan complexes, providing an efficient and cost-effective approach for both NPs synthesis and screening. Microfluidic technologies allow for the synthesis of NPs under controlled conditions, enhancing batch-to-batch reproducibility. Moreover, due to the versatility of microfluidic devices, it is possible to generate and customize endless platforms for rapid and efficient in vitro and in vivo screening of NPs’ performance. Indeed, microfluidic devices show great potential as advanced systems for small organism manipulation and immobilization. In this review, first we summarize the major microfluidic platforms that allow for controlled NPs synthesis. Next, we will discuss the most innovative microfluidic platforms that enable mimicking in vitro environments as well as give insights into organism-on-a-chip and their promising application for NPs screening. We conclude this review with a critical assessment of the current challenges and possible future directions of microfluidic systems in NPs synthesis and screening to impact the field of nanomedicine.

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Section: Microfluidic Devicesmentioning

confidence: 99%

Microfluidic Devices: A Tool for Nanoparticle Synthesis and Performance Evaluation

Gimondi,

Ferreira,

Reis

et al. 2023

ACS Nano

View full text Add to dashboard Cite

show abstract

“…Recently, magnetic nanoparticles (NPs) have been widely explored owing to their unique magnetic properties in various biological applications, such as bioimaging, drug delivery, and diagnostic ferrofluid hyperthermia, showing a high practical application value. 173,174 Zou et al 175 from East China Normal University (China) provided a new strategy for the controlled synthesis of magnetic nanoparticles (ferroferric oxide, Fe 3 O 4 ) with a size of 17-29 nm using a co-precipitation method via a droplet-based continuous microreactor. This chip-type microreactor comprises multifunctional units, in which T-junctions are used for droplet generation; Y-junctions and S-shaped channels are used for droplet fusion and rapid mixing.…”

Section: Synthesis Of Micro/nanomaterials By Microreactorsmentioning

confidence: 99%

Microreactor-based micro/nanomaterials: fabrication, advances, and outlook

et al. 2023

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“…The «bottom-up» approach includes such techniques as hydrothermal, solvothermal, sol–gel, co-precipitation, flow injection syntheses, electrochemical, and laser pyrolysis [ 50 ]. Microfluidic methods of synthesizing magnetic nanoparticles, which are based on “lab-on-a-chip” methods and approaches, were also described [ 51 , 52 ]. Such techniques include continuous-flow microreactors and droplet-based microreactors, based on cross-flow, co-flow, and flow-focusing methods, etc.…”

Section: Synthetic Magnetic Nanoparticlesmentioning

confidence: 99%

Biosensors and Drug Delivery in Oncotheranostics Using Inorganic Synthetic and Biogenic Magnetic Nanoparticles

et al. 2022

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Magnetic nanocarriers have attracted attention in translational oncology due to their ability to be employed both for tumor diagnostics and therapy. This review summarizes data on applications of synthetic and biogenic magnetic nanoparticles (MNPs) in oncological theranostics and related areas. The basics of both types of MNPs including synthesis approaches, structure, and physicochemical properties are discussed. The properties of synthetic MNPs and biogenic MNPs are compared with regard to their antitumor therapeutic efficiency, diagnostic potential, biocompatibility, and cellular toxicity. The comparative analysis demonstrates that both synthetic and biogenic MNPs could be efficiently used for cancer theranostics, including biosensorics and drug delivery. At the same time, reduced toxicity of biogenic particles was noted, which makes them advantageous for in vivo applications, such as drug delivery, or MRI imaging of tumors. Adaptability to surface modification based on natural biochemical processes is also noted, as well as good compatibility with tumor cells and proliferation in them. Advances in the bionanotechnology field should lead to the implementation of MNPs in clinical trials.

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Microfluidic synthesis of magnetic nanoparticles in droplet-based microreactors

Cited by 27 publications

References 47 publications

Microfluidic Devices: A Tool for Nanoparticle Synthesis and Performance Evaluation

Microfluidic Devices: A Tool for Nanoparticle Synthesis and Performance Evaluation

Microreactor-based micro/nanomaterials: fabrication, advances, and outlook

Biosensors and Drug Delivery in Oncotheranostics Using Inorganic Synthetic and Biogenic Magnetic Nanoparticles

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