Microfluidic systems for particle capture and release: A review

Gong, Liyuan; Cretella, Andrew; Lin, Yang

doi:10.1016/j.bios.2023.115426

Cited by 16 publications

(3 citation statements)

References 234 publications

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“…The capacity of microfluidic devices to selectively collect and release certain cells, macromolecules, germs, and particles is one of their noteworthy characteristics. Microfluidic capture and release systems have a number of benefits over conventional batch analyzers, including non-contact operation, high sensitivity, accurate results, label-free identification, and reduced reagent needs [92]. Microfluidic devices provide an alternate method to traditional biochemical separations.…”

Section: Advantages and Disadvantagesmentioning

confidence: 99%

Microfluidic Devices for Precision Nanoparticle Production

Bezelya,

Küçüktürkmen,

Bozkır

2023

Micro

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In recent years, the field of drug delivery has seen a significant shift towards the exploration and utilization of nanoparticles (NPs) as versatile carriers for therapeutic agents. With its ability to provide exact control over NPs’ characteristics, microfluidics has emerged as a potent platform for the efficient and controlled synthesis of NPs. Microfluidic devices designed for precise fluid manipulation at the micro-scale offer a unique platform for tailoring NP properties, enabling enhanced control over NP properties such as size, morphology, and size distribution while ensuring high batch-to-batch reproducibility. Microfluidics can be used to produce liposomes, solid lipid nanoparticles, polymer-based NPs, and lipid-polymer hybrid NPs, as well as a variety of inorganic NPs such as silica, metal, metal oxide, quantum dots, and carbon-based NPs, offering precise control over composition and surface properties. Its unique precision in tailoring NP properties holds great promise for advancing NP-based drug delivery systems in both clinical and industrial settings. Although challenges with large-scale production still remain, microfluidics offers a transformative approach to NP synthesis. In this review, starting from the historical development of microfluidic systems, the materials used to create the systems, microfabrication methods, and system components will be discussed in order to provide the reader with an overview of microfluidic systems. In the following, studies on the fabrication of nanoparticles such as lipid NPs, polymeric NPs, and inorganic NPs in microfluidic devices are included.

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Section: Advantages and Disadvantagesmentioning

confidence: 99%

Microfluidic Devices for Precision Nanoparticle Production

Bezelya,

Küçüktürkmen,

Bozkır

2023

Micro

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“…Circulating tumor cells (CTCs) are a dependable biomarker for cancer diagnosis, detection, and prediction. They are released from primary or metastatic sites of tumors and circulate through peripheral blood to distant body regions ( Hong and Zu, 2013 ; Tang et al, 2016 ; Wang et al, 2023a ; Gong et al, 2023 ). Quick, inexpensive, and highly sensitive techniques to identify CTCs are urgently needed.…”

Section: Introductionmentioning

confidence: 99%

A photoelectrochemical aptasensor based on double Z-scheme α-Fe2O3/MoS2/Bi2S3 ternary heterojunction for sensitive detection of circulating tumor cells

Feng,

Di,

Han

et al. 2024

Front. Bioeng. Biotechnol.

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A novel photoelectrochemical (PEC) aptasensor based on a dual Z-scheme α-Fe2O3/MoS2/Bi2S3 ternary heterojunction for the ultrasensitive detection of circulating tumor cells (CTCs) was developed. The α-Fe2O3/MoS2/Bi2S3 nanocomposite was prepared via a step-by-step route, and the photoproduced electron/hole transfer path was speculated by conducting trapping experiments of reactive species. α-Fe2O3/MoS2/Bi2S3-modified electrodes exhibited greatly enhanced photocurrent under visible light due to the double Z-scheme charge transfer process, which met the requirement of the PEC sensor for detecting larger targets. After the aptamer was conjugated on the photoelectrode through chitosan (CS) and glutaraldehyde (GA), when MCF-7 cells were presented and captured, the photocurrent of the PEC biosensing system decreased due to steric hindrance. The current intensity had a linear relationship with the logarithm of MCF-7 cell concentration ranging from 10 to 1×105 cells mL−1, with a low detection limit of 3 cell mL−1 (S/N = 3). The dual Z-scheme α-Fe2O3/MoS2/Bi2S3 ternary heterojunction-modified PEC aptasensor exhibited high sensitivity and excellent specificity and stability. Additionally, MCF-7 cells in human serum were determined by this PEC aptasensor, exhibiting great potential as a promising tool for clinical detection.

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“…Other reviews have been published on related topics, including molecular concentration enhancement [ 14 , 15 ], particle sorting (by size, density, material, etc.) [ 16 , 17 , 18 ], and single-particle manipulation and trapping, including by optical tweezers [ 19 , 20 , 21 , 22 ]. Some reviews have included methods for localized concentration [ 5 , 19 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Constrained Volume Micro- and Nanoparticle Collection Methods in Microfluidic Systems

Wells,

Schmidt,

Hawkins

2024

Micromachines

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Particle trapping and enrichment into confined volumes can be useful in particle processing and analysis. This review is an evaluation of the methods used to trap and enrich particles into constrained volumes in microfluidic and nanofluidic systems. These methods include physical, optical, electrical, magnetic, acoustic, and some hybrid techniques, all capable of locally enhancing nano- and microparticle concentrations on a microscale. Some key qualitative and quantitative comparison points are also explored, illustrating the specific applicability and challenges of each method. A few applications of these types of particle trapping are also discussed, including enhancing biological and chemical sensors, particle washing techniques, and fluid medium exchange systems.

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Microfluidic systems for particle capture and release: A review

Cited by 16 publications

References 234 publications

Microfluidic Devices for Precision Nanoparticle Production

Microfluidic Devices for Precision Nanoparticle Production

A photoelectrochemical aptasensor based on double Z-scheme α-Fe2O3/MoS2/Bi2S3 ternary heterojunction for sensitive detection of circulating tumor cells

Constrained Volume Micro- and Nanoparticle Collection Methods in Microfluidic Systems

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