Microfluidic Systems for Pathogen Sensing: A Review

Mairhofer, Juergen; Roppert, Kriemhilt; Ertl, Peter

doi:10.3390/s90604804

Cited by 254 publications

(156 citation statements)

References 149 publications

(176 reference statements)

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“…They enable working with small sample amounts in an automatic flow mode and can be implemented as flow-injection analysis, chromatography, or electromigration. [21][22][23][24] In this study, we selected microflow-injection analysis (μFIA) as it provides the highest throughput of analysis and simplicity of the implementation.…”

Section: Introductionmentioning

confidence: 99%

Determination of Trace Cr(VI) with Diphenylcarbazide by μFIA–Thermal Lens Microscopy

Gor’kova

Liu

Проскурнин

et al. 2016

ACSi

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The optimum reaction parameters for the interaction of hexavalent chromium [Cr(VI)] with diphenylcarbazide in microfluidic chips (μFIA) with thermal-lens microscopic detection were selected. The characteristic feature of the applied flow scheme is the injection of the reagent into the stream containing the test metal, which enables in-field and real-time monitoring of Cr(VI) simply by flowing the sample continuously through the microchip. The limit of detection of Cr(VI) under the selected conditions (signal generating wavelength, 514.5 nm; excitation power, 100 mW; detection position, 10 cm downstream from the mixing zone of the microchip; flow rate 10 μL min -1 ; injection volume, 1.4 μL) is 15 ng mL -1 (2.9 × 10 -7 mol L -1 ). The linear range is 40 ng mL -1 -10 μg mL -1 with a relative standard deviation no higher than 10% in the concentration range 0.1-1 μg mL -1 . The online monitoring by this scheme provides the possibility of up to 360 analyses per hour.

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Section: Introductionmentioning

confidence: 99%

Determination of Trace Cr(VI) with Diphenylcarbazide by μFIA–Thermal Lens Microscopy

Gor’kova

Liu

Проскурнин

et al. 2016

ACSi

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“…Such technologies could include field diagnostics for diseases and pathogens, 1 environmental contaminants, 2 and food safety. 3 Several technologies are being actively explored for microfluidic chemical sensors, with devices based on the physics of surface plasmon resonances (SPR) among the most advanced.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing

McFarlane

Manchee

Silverstone

et al. 2013

JoVE

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This paper discusses fluorescent core microcavity-based sensors that can operate in a microfluidic analysis setup. These structures are based on the formation of a fluorescent quantum-dot (QD) coating on the channel surface of a conventional microcapillary. Silicon QDs are especially attractive for this application, owing in part to their negligible toxicity compared to the II-VI and II-VI compound QDs, which are legislatively controlled substances in many countries. While the ensemble emission spectrum is broad and featureless, an Si-QD film on the channel wall of a capillary features a set of sharp, narrow peaks in the fluorescence spectrum, corresponding to the electromagnetic resonances for light trapped within the film. The peak wavelength of these resonances is sensitive to the external medium, thus permitting the device to function as a refractometric sensor in which the QDs never come into physical contact with the analyte. The experimental methods associated with the fabrication of the fluorescent-core microcapillaries are discussed in detail, as well as the analysis methods. Finally, a comparison is made between these structures and the more widely investigated liquid-core optical ring resonators, in terms of microfluidic sensing capabilities. Video LinkThe video component of this article can be found at

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“…The advantages of microfluidics include low cost, short reaction and analysis time, high sensitivity, small footprints, and high-throughput (Whitesides, 2006;Chen et al, 2013). The miniaturization of devices provides additional advantages, such as using small amounts of reagents and integrating several analytical steps (Mairhofer et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Applications of Microfluidics in the Agro-Food Sector: A Review

Kim¹,

Lim²,

Mo³

2016

Journal of Biosystems Engineering

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Background: Microfluidics is of considerable importance in food and agricultural industries. Microfluidics processes low volumes of fluids in channels with extremely small dimensions of tens of micrometers. It enables the miniaturization of analytical devices and reductions in cost and turnaround times. This allows automation, high-throughput analysis, and processing in food and agricultural applications. Purpose: This review aims to provide information on the applications of microfluidics in the agro-food sector to overcome limitations posed by conventional technologies. Results: Microfluidics contributes to medical diagnosis, biological analysis, drug discovery, chemical synthesis, biotechnology, gene sequencing, and ecology. Recently, the applications of microfluidics in food and agricultural industries have increased. A few examples of these applications include food safety analysis, food processing, and animal production. This study examines the fundamentals of microfluidics including fabrication, control, applications, and future trends of microfluidics in the agro-food sector. Conclusions: Future research efforts should focus on developing a small portable platform with modules for fluid handling, sample preparation, and signal detection electronics.

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Microfluidic Systems for Pathogen Sensing: A Review

Cited by 254 publications

References 149 publications

Determination of Trace Cr(VI) with Diphenylcarbazide by μFIA–Thermal Lens Microscopy

Determination of Trace Cr(VI) with Diphenylcarbazide by μFIA–Thermal Lens Microscopy

Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing

Applications of Microfluidics in the Agro-Food Sector: A Review

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