Microfluidically Integrated SERS Active Cell Trap Array for Sensitive Analysis of Red Blood Cells

Hakkel, Orsolya; Rigó, István; Vereš, M.; Fürjes, Péter

doi:10.1109/transducers.2019.8808438

Cited by 1 publication

(2 citation statements)

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“…SERS spectra of normal blood samples have been analyzed with an active SERS microchannel for qualitative assessments utilizing the plasmonic enhancement of surface traps. Results indicate an increased intensity of Raman signals within the structured SERS area [74]. An optical guiding arrangement for Raman spectroscopy has been proposed in which RBCs are used for tailing the optical guide, and spectral analyses have been obtained from the excited resonant cells.…”

Section: Spectroscopic Analysis Of Single Rbcsmentioning

confidence: 99%

“…State-of-the-art [64], isolation of circulating cells [65], clinical diagnosis [66][67][68], bio-particle trapping [69], blood plasma [70], SERS RBC analysis [73,74], optical-guided cell focusing [75], Hb oxygenation uptake [77] Raman scattering related issues, signal overlap, long exposure time, channel dimension and optical scattering trade-off, integrating SERS systems and dynamic trapping of cells, bulky components.…”

Section: Raman Spectra Applicationsmentioning

confidence: 99%

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Advances in Microfluidics for Single Red Blood Cell Analysis

et al. 2023

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The utilizations of microfluidic chips for single RBC (red blood cell) studies have attracted great interests in recent years to filter, trap, analyze, and release single erythrocytes for various applications. Researchers in this field have highlighted the vast potential in developing micro devices for industrial and academia usages, including lab-on-a-chip and organ-on-a-chip systems. This article critically reviews the current state-of-the-art and recent advances of microfluidics for single RBC analyses, including integrated sensors and microfluidic platforms for microscopic/tomographic/spectroscopic single RBC analyses, trapping arrays (including bifurcating channels), dielectrophoretic and agglutination/aggregation studies, as well as clinical implications covering cancer, sepsis, prenatal, and Sickle Cell diseases. Microfluidics based RBC microarrays, sorting/counting and trapping techniques (including acoustic, dielectrophoretic, hydrodynamic, magnetic, and optical techniques) are also reviewed. Lastly, organs on chips, multi-organ chips, and drug discovery involving single RBC are described. The limitations and drawbacks of each technology are addressed and future prospects are discussed.

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Section: Spectroscopic Analysis Of Single Rbcsmentioning

confidence: 99%