Microfluidics-aided fabrication of 3D micro-nano hierarchical SERS substrate for rapid detection of dual hepatocellular carcinoma biomarkers

Zhan, Changbiao; Guan, Zihao; Yu, Liandong; Jing, Tongmei; Jia, Huakun; Chen, Xiaozhe; Gao, Rongke

doi:10.1039/d3lc00907f

Lab Chip

2024

DOI: 10.1039/d3lc00907f

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Microfluidics-aided fabrication of 3D micro-nano hierarchical SERS substrate for rapid detection of dual hepatocellular carcinoma biomarkers

Changbiao Zhan,

Zihao Guan,

Liandong Yu

et al.

Abstract: Simultaneous and trace analysis of dual biomarkers is critical for the early diagnostic, treatment, and prognosis of hepatocellular carcinoma (HCC). In this study, we prepared SERS-active hydrogel microparticles (SAHMs) with...

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Cited by 4 publications

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Microfluidic Synthesis of Magnetic Nanoparticles for Biomedical Applications

Yu,

Zhang,

Yang

et al. 2024

Small Methods

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Magnetic nanoparticles have attracted great attention and become promising candidates in the biomedicine field due to their special physicochemical properties. They are generally divided into metallic and non‐metallic magnetic nanoparticles, according to their compositions. Both of the two types have shown practical values in biomedicine applications, such as drug delivery, biosensing, bioimaging, and so on. Research efforts are devoted to the improvement of synthesis strategies to achieve magnetic nanoparticles with controllable morphology, diverse composition, active surface, or multiple functions. Taking high repeatability, programmable operation, precise fluid control, and simple device into account, the microfluidics system can expand the production scale and develop magnetic nanoparticles with desired features. This review will first describe different classifications of promising magnetic nanoparticles, followed by the advancements in microfluidic synthesis and the latest biomedical applications of these magnetic nanoparticles. In addition, the challenges and prospects of magnetic nanoparticles in the biomedical field are also discussed.

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Microfluidic Synthesis of Magnetic Nanoparticles for Biomedical Applications

Yu,

Zhang,

Yang

et al. 2024

Small Methods

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Dual Detection of Urea and Glucose in Sweat Using a Portable Microfluidic SERS Sensor with Silver Nano-Tripods and 1D-CNN Model Analysis

Xiong,

Wang,

Zhu

et al. 2024

ACS Appl. Mater. Interfaces

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Sweat, a noninvasive metabolic product of normal physiological responses, offers valuable clinical insights into body conditions without causing harm. Key components in sweat, such as urea and glucose, are closely linked to kidney function and blood glucose levels. Portable sweat sensors, equipped with diverse sensing systems, can monitor fluctuations in urea and glucose concentrations, thus providing methods for assessing kidney function and monitoring diabetes. This study presents a flexible, portable microfluidic surface-enhanced Raman scattering (SERS) sensor designed to detect the unique fingerprint of target biomarkers. This flexible, self-adhesive microfluidic chip, constructed from modified polydimethylsiloxane, features silver nanotripods (AgNTs) with densely distributed "hotspots" created via the oblique angle deposition technique. These AgNTs act as active substrates for SERS within the microfluidic platform, enabling direct skin contact to collect, transport, store, and analyze sweat. The chip functions as a quantitative urea sensor with a limit of detection (LOD) of 10 −7 M. For enhanced sensitivity for glucose detection, the SERS substrate is modified with 4-mercaptophenylboronic acid, achieving a LOD of 10 −7 M. This satisfies the measurement requirements for both urea and glucose in sweat under physiological conditions. Furthermore, the one-dimensional convolutional neural network model significantly enhances the accuracy of biomarker detection, facilitating the quantitative analysis of urea and glucose. This advancement contributes to the development of a controlled, convenient, and dynamic biosensing system for personalized point-of-care testing and supports the creation of intelligent wearable and nondestructive devices.

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SERS-based pump-free microfluidic chip sensor for highly sensitive competitive immunoassay of cortisol in human sweat

Xiong,

Zhu,

Wang

et al. 2024

Lab Chip

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Microfluidics-aided fabrication of 3D micro-nano hierarchical SERS substrate for rapid detection of dual hepatocellular carcinoma biomarkers

Abstract: Simultaneous and trace analysis of dual biomarkers is critical for the early diagnostic, treatment, and prognosis of hepatocellular carcinoma (HCC). In this study, we prepared SERS-active hydrogel microparticles (SAHMs) with...

Cited by 4 publications

References 50 publications

Microfluidic Synthesis of Magnetic Nanoparticles for Biomedical Applications

Microfluidic Synthesis of Magnetic Nanoparticles for Biomedical Applications

Dual Detection of Urea and Glucose in Sweat Using a Portable Microfluidic SERS Sensor with Silver Nano-Tripods and 1D-CNN Model Analysis

SERS-based pump-free microfluidic chip sensor for highly sensitive competitive immunoassay of cortisol in human sweat

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