Microfluidics assisted generation of innovative polysaccharide hydrogel microparticles

Marquis, Mélanie; Davy, Joëlle; Cathala, Bernard; Fang, Aiping; Renard, Denis

doi:10.1016/j.carbpol.2014.01.083

Cited by 51 publications

(37 citation statements)

References 74 publications

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“…Lithographic methods likewise offer good control over particle polydispersity, but are in general slower than batch polymerization methods. Microfluidic and lithographic synthesis schemes also allow for improved control over particle structure and complexity (e.g., Janus microgels, 46 core-shell microgels 3 ) as compared to batch schemes. Lastly, although less common, electrospraying techniques can also be utilized to fabricate microgels.…”

Section: Fabrication Methods For Microgelsmentioning

confidence: 99%

“…46 The separation of the two hemispheres was shown by confocal scanning laser microscopy, and the diffusivity of encapsulated bovine serum albumin depended on its placement in either the pectin or the alginate hemisphere of the microgel. In addition, use of specific enzymes against the two different polysaccharides that comprised the Janus microgels resulted in selective degradation of either hemisphere.…”

Section: Polymers Commonly Used For Microgelsmentioning

confidence: 99%

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Methods for Generating Hydrogel Particles for Protein Delivery

Liu

Garcı́a

2016

Ann Biomed Eng

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Proteins represent a major class of therapeutic molecules with vast potential for the treatment of acute and chronic diseases and regenerative medicine applications. Hydrogels have long been investigated for their potential in carrying and delivering proteins. As compared to bulk hydrogels, hydrogel microparticles (microgels) hold promise in improving aspects of delivery owing to their less traumatic route of entry into the body and improved versatility. This review discusses common methods of fabricating microgels, including emulsion polymerization, microfluidic techniques, and lithographic techniques. Microgels synthesized from both natural and synthetic polymers are discussed, as are a series of microgels fashioned from environment-responsive materials.

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Section: Fabrication Methods For Microgelsmentioning

confidence: 99%

Section: Polymers Commonly Used For Microgelsmentioning

confidence: 99%

Methods for Generating Hydrogel Particles for Protein Delivery

Liu

Garcı́a

2016

Ann Biomed Eng

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“…Therefore, its suitability for efficient colon drug delivery has been investigated previously. However, the focus in the past has primarily been on solid particles/beads [1, 3] and to a lesser extent on hydrogel particles [4, 5] or oil-core microcapsules [6]. Microcapsules based on rhamnogalacturonan-I (RG-I), which is the focus in the present paper, have not previously been reported.…”

Section: Introductionmentioning

confidence: 99%

Rhamnogalacturonan-I Based Microcapsules for Targeted Drug Release

et al. 2016

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Drug targeting to the colon via the oral administration route for local treatment of e.g. inflammatory bowel disease and colonic cancer has several advantages such as needle-free administration and low infection risk. A new source for delivery is plant-polysaccharide based delivery platforms such as Rhamnogalacturonan-I (RG-I). In the gastro-intestinal tract the RG-I is only degraded by the action of the colonic microflora. For assessment of potential drug delivery properties, RG-I based microcapsules (~1 μm in diameter) were prepared by an interfacial poly-addition reaction. The cross-linked capsules were loaded with a fluorescent dye (model drug). The capsules showed negligible and very little in vitro release when subjected to media simulating gastric and intestinal fluids, respectively. However, upon exposure to a cocktail of commercial RG-I cleaving enzymes, ~ 9 times higher release was observed, demonstrating that the capsules can be opened by enzymatic degradation. The combined results suggest a potential platform for targeted drug delivery in the terminal gastro-intestinal tract.

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“…For example, two types of microgel-capsule structures, bulk microcapsules and core-shell structures, could be easily tailored by droplet-based microfluidic templating followed by subsequent droplet gelation [120]. Furthermore, droplet microfluidics has been applied in manufacturing poly(lactide-co-glycolide)/TiO 2 hybrid microparticles [121], silica microparticles [122], and polysaccharide hydrogel microparticles [79] of various shapes such as spherical, ellipsoidal, disk-like, and rod-like.…”

Section: Particle Shapingmentioning

confidence: 99%

“…[79] Microfluidic synthesis of monodisperse PEGDA microbeads for sustained release of 5-fluorouracil Poly(ethylene glycol) diacrylate microbeads encapsulating 5-fluorouracil…”

Section: Cell Biologymentioning

confidence: 99%

Recent Advances in Applications of Droplet Microfluidics

et al. 2015

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Droplet-based microfluidics is a colloidal and interfacial system that has rapidly progressed in the past decade because of the advantages of low fabrication costs, small sample volumes, reduced analysis durations, high-throughput analysis with exceptional sensitivity, enhanced operational flexibility, and facile automation. This technology has emerged as a new tool for many recently used applications in molecular detection, imaging, drug delivery, diagnostics, cell biology and other fields. Herein, we review recent applications of droplet microfluidics proposed since 2013.

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Microfluidics assisted generation of innovative polysaccharide hydrogel microparticles

Cited by 51 publications

References 74 publications

Methods for Generating Hydrogel Particles for Protein Delivery

Methods for Generating Hydrogel Particles for Protein Delivery

Rhamnogalacturonan-I Based Microcapsules for Targeted Drug Release

Recent Advances in Applications of Droplet Microfluidics

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