Microfluidics-Based Plasmonic Biosensing System Based on Patterned Plasmonic Nanostructure Arrays

Abstract

This review aims to summarize the recent advances and progress of plasmonic biosensors based on patterned plasmonic nanostructure arrays that are integrated with microfluidic chips for various biomedical detection applications. The plasmonic biosensors have made rapid progress in miniaturization sensors with greatly enhanced performance through the continuous advances in plasmon resonance techniques such as surface plasmon resonance (SPR) and localized SPR (LSPR)-based refractive index sensing, SPR imaging (SPRi), and surface-enhanced Raman scattering (SERS). Meanwhile, microfluidic integration promotes multiplexing opportunities for the plasmonic biosensors in the simultaneous detection of multiple analytes. Particularly, different types of microfluidic-integrated plasmonic biosensor systems based on versatile patterned plasmonic nanostructured arrays were reviewed comprehensively, including their methods and relevant typical works. The microfluidics-based plasmonic biosensors provide a high-throughput platform for the biochemical molecular analysis with the advantages such as ultra-high sensitivity, label-free, and real time performance; thus, they continue to benefit the existing and emerging applications of biomedical studies, chemical analyses, and point-of-care diagnostics.

Multiplex optical bioassays for food safety analysis: Toward on‐site detection

“…Another challenge in food analysis is the complex food matrixes that have to be addressed during sample preparation procedures and also the biomolecular interactions that take place. Nonetheless, microfluidics‐based multiplex SPR biosensors provide a high‐throughput platform for biomedical molecular analysis with the advantages of ultrahigh sensitivity and real‐time performance (Liu et al., 2021). Thus, they will continue to benefit existing and emerging applications such as point‐of‐care diagnostics, food safety screening, and environmental monitoring.…”

Microfluidic-Chip-Integrated Biosensors for Lung Disease Models

“…The development of biosensors has generally gone through the following three stages: (1) the first generation of biosensors consists of electrochemical electrodes and inactive matrix membranes (dialysis membranes or reaction membranes) with fixed biological components; (2) the second generation of biosensors-biological components directly adsorbed or covalently bound to the surface of the converter-do not need the inactive matrix membrane, and do not need to add other reagents to the sample; (3) in the third generation of biosensors, biological components are directly fixed on the electronic components, and can directly sense and amplify the changes in interface substances, so as to combine biometric recognition and signal conversion processing. Biosensors have been incorporated into OOC platforms for a long time, in order to allow for in situ, real-time, small-volume detection of biochemical parameters with minor disturbances to the system [29,37,[104][105][106][107][108][109][110]. In this review, we summarized biosensor-free (Table 1) and biosensor-integrated (Table 2) LOC models, illustrating the chip design and sensing signals of biosensor-integrated LOCs in detail by using examples of related studies.…”

Lossy Mode Resonance Based Microfluidic Platform Developed on Planar Waveguide for Biosensing Applications

“…The integration of microfluidics with biosensor technology offers new opportunities for future applications with improvements in portability, real-time detection, higher accuracy, increased sensitivity, and simultaneous analysis of different analytes in a single device. In the field of optical biosensors, we find a variety of devices integrated into microfluidic systems, some of them based on long-period grating (LPG) [ 18 ], Mach-Zehnder interferometry [ 19 ], or SPR [ 20 , 21 , 22 ].…”