Microfluidics-based PLGA nanoparticles of ratiometric multidrug: From encapsulation and release rates to cytotoxicity in human lens epithelial cells

Sorafenib and Piperine co-loaded PLGA nanoparticles: Development, characterization, and anti-cancer activity against hepatocellular carcinoma cell line

“…The calculated values of the diffusion-exponents (<0.5) for the best-fitted models indicate that the released drugs followed a Fickian-Diffusion type of release mechanism, as suggested in previous reports ( Chime et al, 2013 , Guo et al, 2023 , Ritger and Peppas, 1987 , Unagolla and Jayasuriya, 2018 ).…”

Antitumoral-Embedded Biopolymeric Spheres for Implantable Devices

“…Other maxima, though reduced in intensity, were identified in the last spectral region, namely the copolymer's C-H out-of-plane bending at ~750 cm −1 and the apatite's O-P-O asymmetric deformation between 610 and 550 cm −1 . Overlapped PLGA [71] and HA [72] vibrations were noticed in region III (C-O stretching at ~1180 cm −1 ) and region II (C-H asymmetric and symmetric deformation, and C-O bending at ~1450 cm −1 ), while region II also contained superposed MTX (carboxamide and aromatic C=C vibrations between 1550 and 1400 cm −1 ) [54,73] and PLGA (-CH 3 and -CH 2 -bending at ~1380 cm −1 ) [74,75] vibrations. The IR spectrum of the initial sample confirmed the formation of PLGA/HA-MTX composites by the clear presence of PLGA-originating (region I) and HA-originating (region III) moieties like symmetric C=O stretching (~1750 cm -1 ) [58,68] and asymmetric (~1130, ~1080, and ~1040 cm -1 ) and symmetric (~960 and ~860 cm -1 ) stretching of P-O [69,70], respectively.…”

“…Other maxima, though reduced in intensity, were identified in the last spectral region, namely the copolymer’s C–H out-of-plane bending at ~750 cm −1 and the apatite’s O–P–O asymmetric deformation between 610 and 550 cm −1 . Overlapped PLGA [ 71 ] and HA [ 72 ] vibrations were noticed in region III (C–O stretching at ~1180 cm −1 ) and region II (C–H asymmetric and symmetric deformation, and C–O bending at ~1450 cm −1 ), while region II also contained superposed MTX (carboxamide and aromatic C=C vibrations between 1550 and 1400 cm −1 ) [ 54 , 73 ] and PLGA (–CH 3 and –CH 2 – bending at ~1380 cm −1 ) [ 74 , 75 ] vibrations.…”

Development of PSL-Loaded PLGA Nanoparticles for the Treatment of Allergic Contact Dermatitis

“…As the L/G ratio, which is the composition ratio of PLGA used, decreases, the release rate of the encapsulated drug increases. This is because the hydrolysis of more glycolic acid accelerates the release of the contained drug [22]. The PLGA used in this study has a high L/G ratio, so the release rate is expected to be slow.…”