Microfluidics for cell-cell interactions: A review

Li, Rui; Lv, Xuefei; Zhang, Xingjian; Saeed, Omer; Deng, Yulin

doi:10.1007/s11705-015-1550-2

Cited by 39 publications

(28 citation statements)

References 82 publications

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“…The 3D structure provides the foundation of human complex tissue network and is proper to serve as a study model in microfluidics. Other designs of chips for cell-cell interactions include microvalves, microchannels and membrane as shown in reference [63][64][65][66][67][68] (Figure 2b-d) and to control administration of metabolites from one kind of cells to the receptor cells, our group had once presented a so called surface tension plug on a microfluidic device. Based on this device, we investigated the signal pathway between 293 and L-02 cells [69].…”

Section: Gradient Of Chemical Factorsmentioning

confidence: 99%

Development and Applications of Microfluidic Devices for Cell Culture in Cell Biology

Yi¹,

Lin²

2016

Mol Biol

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Development of microfluidic culture technology combined with tissue engineering catalyzes the progress in study of cell biology. These tools will promote the understanding of physiological and pathological changes. Cancer cells and stem cells are sensitive to their surroundings, thus could be better explored by controllable microfluidic devices. In this review, we describe the ways to control cell microenvironment and explain how the influencing factors influence cellular behaviors, then present microfluidic-chip-based exemplary applications for cancer models and stem cell differentiation.

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Section: Gradient Of Chemical Factorsmentioning

confidence: 99%

Development and Applications of Microfluidic Devices for Cell Culture in Cell Biology

Yi¹,

Lin²

2016

Mol Biol

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“…Eternal aspiration of inquiring biology at a single subsistence level has contrived microfluidic noticeably into the organic (living) space [1]. Invariably, due to its miniaturized length scale, rapidity in the analysis, the selective capacity to minimize the volume of reagent, and reduction in turnaround, small-scale fluidics have facilitated the area of natural science [2,3].…”

Section: Introductionmentioning

confidence: 99%

Advancements and Potential Applications of Microfluidic Approaches—A Review

Ahmed¹,

Akram²,

Bule

et al. 2018

Chemosensors

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A micro-level technique so-called “microfluidic technology or simply microfluidic” has gained a special place as a powerful tool in bioengineering and biomedical engineering research due to its core advantages in modern science and engineering. Microfluidic technology has played a substantial role in numerous applications with special reference to bioscience, biomedical and biotechnological research. It has facilitated noteworthy development in various sectors of bio-research and upsurges the efficacy of research at the molecular level, in recent years. Microfluidic technology can manipulate sample volumes with precise control outside cellular microenvironment, at micro-level. Thus, enable the reduction of discrepancies between in vivo and in vitro environments and reduce the overall reaction time and cost. In this review, we discuss various integrations of microfluidic technologies into biotechnology and its paradigmatic significance in bio-research, supporting mechanical and chemical in vitro cellular microenvironment. Furthermore, specific innovations related to the application of microfluidics to advance microbial life, solitary and co-cultures along with a multiple-type cell culturing, cellular communications, cellular interactions, and population dynamics are also discussed.

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“…Eternal aspiration of inquiring biology at a single subsistence level has contrived microfluidic noticeably into the organic (living) space [1]. Invariably, due to its miniaturised length scale, rapidity in analysis, the selective capacity to minimize the volume of reagent, and reduction in turnaround, small scale fluidics has facilitated exceptional and approaching scene in the walled in area of natural science [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies illustrated a basic two-dimensional (2D) microstructure utilised for cells cultivation and mainly employed to fabricate a microfluidic framework exhibiting required characteristics [14,15]. Although microfluidic tools attained sophisticated advancement with an end goal to understand impeccable in vivo conditions on a chip, tools have been adjusted for utilisation with polymer platforms and three dimensional (3D) microstructures, guaranteeing different layers for co-cultures or 3D cell development [1,16]. Hence, the present study covers the advantages and challenges of using microfluidics in cell culture.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Advancements in Classical Biotechnology – A Review

Ahmed¹,

Akram²,

Bule³

et al. 2018

Preprint

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Micro-technology has played a substantial role in bioscience, biomedical and biotechnological research due to its core advantages in modern science and engineering. It has created unique development in various sectors of bio-research and upsurges the efficacy of research at the molecular level in recent years. Microfluidic technology makes it possible to manipulate sample volumes at the micro-and nano-level (called nanofluidics) with terrific control outside in vivo cellular microenvironment, enabling the reduction of discrepancies between in vivo and in vitro environments as well as reducing reaction time and cost. In this review, we discuss various effective integrations of microfluidic technologies into biotechnology and its paradigmatic significance in bioresearch, supporting mechanical and chemical in vitro cellular micro-environment. Specific innovations relating to the application of microfluidics to advance microbial life, solitary and cocultures along with a multiple-type cell culturing, cellular communications, cellular interactions and population dynamics are discussed.

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Microfluidics for cell-cell interactions: A review

Cited by 39 publications

References 82 publications

Development and Applications of Microfluidic Devices for Cell Culture in Cell Biology

Development and Applications of Microfluidic Devices for Cell Culture in Cell Biology

Advancements and Potential Applications of Microfluidic Approaches—A Review

Microfluidic Advancements in Classical Biotechnology – A Review

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Microfluidics for cell-cell interactions: A review

Cited by 39 publications

References 82 publications

Development and Applications of Microfluidic Devices for Cell Culture in Cell Biology

Development and Applications of Microfluidic Devices for Cell Culture in Cell Biology

Advancements and Potential Applications of Microfluidic Approaches—A Review

Microfluidic Advancements in Classical Biotechnology &ndash; A Review

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Microfluidic Advancements in Classical Biotechnology – A Review