Microfluidics for ZnO micro-/nanomaterials development: rational design, controllable synthesis, and on-chip bioapplications

Hao, Nanjing; Zhang, Michael; Zhang, John X. J.

doi:10.1039/c9bm01787a

Cited by 42 publications

(40 citation statements)

References 117 publications

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“…The synthesis techniques used for ZnO NPs/MPs are generally categorized by physical, chemical, biological, and microfluidic methods [ 5 , 34 ]. Physical methods of arc plasma, thermal evaporation, physical vapor deposition, ultrasonic irradiation, and laser ablation simply produce chemically pure ZnO NPs/MPs.…”

Section: Characteristics Of Zno Materials Based On Synthesis Technmentioning

confidence: 99%

Antimicrobial Activity of Zinc Oxide Nano/Microparticles and Their Combinations against Pathogenic Microorganisms for Biomedical Applications: From Physicochemical Characteristics to Pharmacological Aspects

Jin

2021

Nanomaterials

130

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Zinc oxide (ZnO) nano/microparticles (NPs/MPs) have been studied as antibiotics to enhance antimicrobial activity against pathogenic bacteria and viruses with or without antibiotic resistance. They have unique physicochemical characteristics that can affect biological and toxicological responses in microorganisms. Metal ion release, particle adsorption, and reactive oxygen species generation are the main mechanisms underlying their antimicrobial action. In this review, we describe the physicochemical characteristics of ZnO NPs/MPs related to biological and toxicological effects and discuss the recent findings of the antimicrobial activity of ZnO NPs/MPs and their combinations with other materials against pathogenic microorganisms. Current biomedical applications of ZnO NPs/MPs and combinations with other materials are also presented. This review will provide the better understanding of ZnO NPs/MPs as antibiotic alternatives and aid in further development of antibiotic agents for industrial and clinical applications.

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Section: Characteristics Of Zno Materials Based On Synthesis Technmentioning

confidence: 99%

Antimicrobial Activity of Zinc Oxide Nano/Microparticles and Their Combinations against Pathogenic Microorganisms for Biomedical Applications: From Physicochemical Characteristics to Pharmacological Aspects

Jin

2021

Nanomaterials

130

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“…To obtain high-quality ZnO NPs, their synthesis can be performed in microfluidic devices as well. The controlled production of ZnO NPs with well-defined physicochemical properties has already been demonstrated to be effective for various shapes, such as wires, spheres, rods, spindles, ellipsoids, and sheets [ 116 ].…”

Section: Nanomaterials Synthesized Through Microfluidic Methodsmentioning

confidence: 99%

Nanomaterials Synthesis through Microfluidic Methods: An Updated Overview

et al. 2021

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Microfluidic devices emerged due to an interdisciplinary “collision” between chemistry, physics, biology, fluid dynamics, microelectronics, and material science. Such devices can act as reaction vessels for many chemical and biological processes, reducing the occupied space, equipment costs, and reaction times while enhancing the quality of the synthesized products. Due to this series of advantages compared to classical synthesis methods, microfluidic technology managed to gather considerable scientific interest towards nanomaterials production. Thus, a new era of possibilities regarding the design and development of numerous applications within the pharmaceutical and medical fields has emerged. In this context, the present review provides a thorough comparison between conventional methods and microfluidic approaches for nanomaterials synthesis, presenting the most recent research advancements within the field.

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“…Specifically, ZnO nanoarray was first engineered inside glass capillary via a two-step seeding and growth approach. [70,71] The glass capillary was activated by freshly prepared KMnO 4 (5 × 10 −3 m, containing 50 µL 1-butanol per 20 mL solution) at 65 °C for 15 min. ZnO seeds were then patterned using one inlet containing Zn(OAc) 2 (2.5 × 10 −3 m) and the other NaOH (5 × 10 −3 m).…”

Section: Development Of Plasmonic Zno-ag Nanoarray-coated Glass Capilmentioning

confidence: 99%

Acoustofluidics‐Assisted Fluorescence‐SERS Bimodal Biosensors

Hao

Pei

Liu

et al. 2020

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Acoustofluidics, the fusion of acoustics and microfluidic techniques, has recently seen increased research attention across multiple disciplines due in part to its capabilities in contactless, biocompatible, and precise manipulation of micro‐/nano‐objects. Herein, a bimodal signal amplification platform which relies on acoustofluidics‐induced enrichment of nanoparticles is introduced. The dual‐function biosensor can perform sensitive immunofluorescent or surface‐enhanced Raman spectroscopy (SERS) detection. The platform functions by using surface acoustic waves to concentrate nanoparticles at either the center or perimeter of a glass capillary; the concentration location is adjusted simply by varying the input frequency. The immunofluorescence assay is achieved by concentrating fluorescent analytes and functionalized nanoparticles at the center of the microchannel, thereby improving the visibility of the fluorescent output. By modifying the inner wall of the glass capillary with plasmonic Ag nanoparticle‐deposited ZnO nanorod arrays and focusing analytes toward the perimeter of the microchannel, SERS sensing using the same device setup is achieved. Nanosized exosomes are used as a proof‐of‐concept to validate the performance of the acoustofluidic bimodal biosensor. With its sample‐enrichment functionality, bimodal sensing, short processing time, and minute sample consumption, the acoustofluidic chip holds great potential for the development of lab‐on‐a‐chip based analysis systems in many real‐world applications.

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Microfluidics for ZnO micro-/nanomaterials development: rational design, controllable synthesis, and on-chip bioapplications

Abstract: This review provides a comprehensive summary of recent advances in microfluidics-enabled controllable synthesis and bioapplications of ZnO micro-/nanomaterials.

Cited by 42 publications

References 117 publications

Antimicrobial Activity of Zinc Oxide Nano/Microparticles and Their Combinations against Pathogenic Microorganisms for Biomedical Applications: From Physicochemical Characteristics to Pharmacological Aspects

Antimicrobial Activity of Zinc Oxide Nano/Microparticles and Their Combinations against Pathogenic Microorganisms for Biomedical Applications: From Physicochemical Characteristics to Pharmacological Aspects

Nanomaterials Synthesis through Microfluidic Methods: An Updated Overview

Acoustofluidics‐Assisted Fluorescence‐SERS Bimodal Biosensors

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