Microfluidics in Microbiome and Cancer Research

Udayasuryan, Barath; Slade, Daniel J.; Verbridge, Scott S.

doi:10.1002/9783527818341.ch9

Cited by 2 publications

(2 citation statements)

References 142 publications

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“…Another interesting innovation in the area of microfluidics in microbiome research is the development of organs on chip. This has allowed the design of experiments that captures minute complexities of microenvironment with extraordinary resolution, giving details of the microbial diversity, structure and functions of the microbiota of specific organs of the human system [ 59 ]. The development of a primary human small intestine on a chip using biopsy derived organoids by Kasendra et al [ 60 ] (as shown in Figure 2 ), in which they suggested that its potential use in the study of infection, metabolism, drug pharmacokinetics and nutrition can be a viable and efficient tool in studying human gastrointestinal microbiota.…”

Section: Resultsmentioning

confidence: 99%

Evolving Technologies in Gastrointestinal Microbiome Era and Their Potential Clinical Applications

Ajayi

Jolaiya

Smith

2020

JCM

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The human gastrointestinal microbiota (GIM) is a complex and diverse ecosystem that consists of community of fungi, viruses, protists and majorly bacteria. The association of several human illnesses, such as inflammatory bowel disease, allergy, metabolic syndrome and cancers, have been linked directly or indirectly to compromise in the integrity of the GIM, for which some medical interventions have been proposed or attempted. This review highlights and gives update on various technologies, including microfluidics, high-through-put sequencing, metabolomics, metatranscriptomics and culture in GIM research and their applications in gastrointestinal microbiota therapy, with a view to raise interest in the evaluation, validation and eventual use of these technologies in diagnosis and the incorporation of therapies in routine clinical practice.

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Section: Resultsmentioning

confidence: 99%

Evolving Technologies in Gastrointestinal Microbiome Era and Their Potential Clinical Applications

Ajayi

Jolaiya

Smith

2020

JCM

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“…The human microbiome, consisting of trillions of microorganisms co-existing within the human body, has an enormous impact on maintaining health and normal physiology (Brestoff and Artis, 2013;Fan and Pedersen, 2020). A dysbiotic microbiome adversely impacts homeostasis, which leads to a number of unfavorable outcomes including inflammatory diseases, cardiovascular disease, obesity, and diabetes and can even potentiate cancer initiation and progression (Udayasuryan et al, 2019;Xavier et al, 2020). Studies of the microbiome often characterize microbial compositional alterations in disease conditions (Durack and Lynch, 2019).…”

Section: The Tumor Microbiomementioning

confidence: 99%

Harnessing Tissue Engineering Tools to Interrogate Host-Microbiota Crosstalk in Cancer

et al. 2020

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Recent studies have begun to highlight the diverse and tumor-specific microbiomes across multiple cancer types. We believe this work raises the important question of whether the classical ''Hallmarks of Cancer'' should be expanded to include tumor microbiomes. To answer this question, the causal relationships and co-evolution of these microbiotic tumor ecosystems must be better understood. Because host-microbe interactions should be studied in a physiologically relevant context, animal models have been preferred. Yet these models are often poor mimics of human tumors and are difficult to interrogate at high spatiotemporal resolution. We believe that in vitro tissue engineered platforms could provide a powerful alternative approach that combines the high-resolution of in vitro studies with a high degree of physiological relevance. This review will focus on tissue engineered approaches to study host-microbe interactions and to establish their role as an emerging hallmark of cancer with potential as a therapeutic target.

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Microfluidics in Microbiome and Cancer Research

Cited by 2 publications

References 142 publications

Evolving Technologies in Gastrointestinal Microbiome Era and Their Potential Clinical Applications

Evolving Technologies in Gastrointestinal Microbiome Era and Their Potential Clinical Applications

Harnessing Tissue Engineering Tools to Interrogate Host-Microbiota Crosstalk in Cancer

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