Microfluidics in tissue engineering

Sinha, Sukanta; Bit, Arindam

doi:10.1016/b978-0-08-102906-0.00010-6

Cited by 3 publications

References 127 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Microfluidic Tissue Engineering and Bio‐Actuation

et al. 2022

View full text Add to dashboard Cite

Bio‐hybrid technologies aim to replicate the unique capabilities of biological systems that could surpass advanced artificial technologies. Soft bio‐hybrid robots consist of synthetic and living materials and have the potential to self‐assemble, regenerate, work autonomously, and interact safely with other species and the environment. Cells require a sufficient exchange of nutrients and gases, which is guaranteed by convection and diffusive transport through liquid media. The functional development and long‐term survival of biological tissues in vitro can be improved by dynamic flow culture, but only microfluidic flow control can develop tissue with fine structuring and regulation at the microscale. Full control of tissue growth at the microscale will eventually lead to functional macroscale constructs, which are needed as the biological component of soft bio‐hybrid technologies. This review summarizes recent progress in microfluidic techniques to engineer biological tissues, focusing on the use of muscle cells for robotic bio‐actuation. Moreover, the instances in which bio‐actuation technologies greatly benefit from fusion with microfluidics are highlighted, which include: the microfabrication of matrices, biomimicry of cell microenvironments, tissue maturation, perfusion, and vascularization.

show abstract

Microfluidic Tissue Engineering and Bio‐Actuation

et al. 2022

View full text Add to dashboard Cite

show abstract

Microfluidic systems toward blood hemostasis monitoring and thrombosis diagnosis: From design principles to micro/nano fabrication technologies

Nie

et al. 2022

VIEW

View full text Add to dashboard Cite

Perfusable endothelialized models of microfluidic systems that recapitulate unique biological and biophysical microvasculature conditions are improved with micro/nano engineering advances for monitoring of blood hemostasis and thrombosis treatment. Although bio‐sensors and monitoring devices significantly advance in measuring platelet aggregation and thrombosis kinetics, currently platelet aggregation tests still do not meet the arising clinical requirements. Trying to seek new solutions for such a demanding from clinics, the present review provides an overview of design principles of microfluidic systems and micro/nano fabrication strategies in studying the platelet adhesion and aggregation. We critically sketch the characteristics of microfluidic systems to elucidate the role of platelets in the complex process of thrombus formation. The importance, benefits, and challenges of introduced principles and methods are discussed. The potential from various of basic research to clinical applications is also briefly discussed to help guide designing more versatile point‐of‐care devices for hemostasis monitoring and thrombosis diagnosis and treatment.

show abstract

Lab-on-a-chip: Fabrication and Frontiers Aiming at Biomedicines

Ahmed,

Tisha

2024

Lab-on-a-Chip Devices for Advanced Biomedicines

View full text Add to dashboard Cite

The adoption of lab-on-a-chip (LOC) technology has significantly influenced the integration and miniaturization of analytical procedures in the field of biomedicine. This chapter focuses on a thorough exploration of the fabrication methods used to advance LOC devices, with a significant focus on their applications and developments in biomedicine. Microfluidics allows precise fluid manipulation, whereas micro- and nanofabrication techniques enable the combination of several capabilities onto a single chip. LOC technology has versatile uses in personalized medicine, disease diagnostics, and drug development. High-throughput screening is facilitated by these instruments, which enable quick biomarker identification. Sensing technologies have made considerable strides, particularly in nanoparticle-based detection and biosensors. These developments have significantly enhanced analytical capabilities, enabling more accurate and precise measurements across various applications. Furthermore, the advancement of organ-on-a-chip technology has facilitated the mimicking of physiological environments, hence offering valuable contributions to the domains of drug testing and disease simulation. The use of LOC technology offers significant promise for the development of innovative biomedical devices, resulting in a substantial impact on the areas of drug discovery, disease detection, and personalized medicine, ultimately improving patient outcomes.

show abstract

Microfluidics in tissue engineering

Cited by 3 publications

References 127 publications

Microfluidic Tissue Engineering and Bio‐Actuation

Microfluidic Tissue Engineering and Bio‐Actuation

Microfluidic systems toward blood hemostasis monitoring and thrombosis diagnosis: From design principles to micro/nano fabrication technologies

Lab-on-a-chip: Fabrication and Frontiers Aiming at Biomedicines

Contact Info

Product

Resources

About