Microfluidics with new multi-stage arc-unit structures for size-based cross-flow separation of microparticles

Lee, Yee-Ting; Dang, Chaobin; Hong, Sihui; Yang, An-Shik; Su, Tsai-Lung; Yang, Yung-Chun

doi:10.1016/j.mee.2019.01.005

“…Membrane-based separation is a pressure-driven process [ 141 , 142 ], which has been widely used for microfiltration, ultrafiltration, reverse osmosis, ion-exchange, and gas separation [ 143 ]. The size-based crossflow separation can also be achieved using multistage arc-unit structures in a microfluidic device as shown in Figure 4 [ 141 ].…”

Section: Microfluidic Separation Methodsmentioning

confidence: 99%

“…Membrane-based separation is a pressure-driven process [ 141 , 142 ], which has been widely used for microfiltration, ultrafiltration, reverse osmosis, ion-exchange, and gas separation [ 143 ]. The size-based crossflow separation can also be achieved using multistage arc-unit structures in a microfluidic device as shown in Figure 4 [ 141 ]. Chen et al [ 144 ] proposed a method for preparation of microfiltration membranes made up with cellulose acetate (CA) blended with polyethyleneimine (PEI), where PEI can provide coupling sites for ligands in affinity separation or be used as a ligand for metal chelating, endotoxin removal, or ion exchange.…”

Section: Microfluidic Separation Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Public-Health-Driven Microfluidic Technologies: From Separation to Detection

Zhang

¹

,

Xu

²

,

Wang

³

et al. 2021

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Separation and detection are ubiquitous in our daily life and they are two of the most important steps toward practical biomedical diagnostics and industrial applications. A deep understanding of working principles and examples of separation and detection enables a plethora of applications from blood test and air/water quality monitoring to food safety and biosecurity; none of which are irrelevant to public health. Microfluidics can separate and detect various particles/aerosols as well as cells/viruses in a cost-effective and easy-to-operate manner. There are a number of papers reviewing microfluidic separation and detection, but to the best of our knowledge, the two topics are normally reviewed separately. In fact, these two themes are closely related with each other from the perspectives of public health: understanding separation or sorting technique will lead to the development of new detection methods, thereby providing new paths to guide the separation routes. Therefore, the purpose of this review paper is two-fold: reporting the latest developments in the application of microfluidics for separation and outlining the emerging research in microfluidic detection. The dominating microfluidics-based passive separation methods and detection methods are discussed, along with the future perspectives and challenges being discussed. Our work inspires novel development of separation and detection methods for the benefits of public health.

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“…Membrane-based separation is a pressure-driven process [141,142], which has been widely used for microfiltration, ultrafiltration, reverse osmosis, ion-exchange, and gas separation [143]. The size-based crossflow separation can also be achieved using multistage arc-unit structures in a microfluidic device as shown in Figure 4 [141].…”

Section: Microscale Filtersmentioning

confidence: 99%

Particles Separation in Microfluidic Devices, Volume II

2022

0

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High throughput clogging free microfluidic particle filter by femtosecond laser micromachining

Storti,

Bonfadini,

Mangini

et al. 2024

Electrophoresis

0

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In recent decades, driven by the needs of industry and medicine, researchers have been investigating how to remove carefully from the main flow microscopic particles or clusters of them. Among all the approaches proposed, crossflow filtration is one of the most attractive as it provides a non‐destructive, label‐free and in‐flow sorting method. In general, the separation performance shows capture and separation efficiencies ranging from 70% up to 100%. However, the maximum flow rate achievable (µL/min) is still orders of magnitude away from those suitable for clinical or industrial applications mainly due to the low stiffness of the materials typically used. In this work, we propose an innovative hydrodynamic‐crossflow hybrid filter geometry, buried in a fused silica substrate by means of the femtosecond laser irradiation followed by chemical etching technique. The material high stiffness combined with the accuracy of our manufacturing technique allows the 3D fabrication of non‐deformable channels with higher aspect ratio posts, while keeping the overall device dimensions compact. The filter performance has been validated through experiments with both Newtonian (water‐based solution of microbeads) and non‐Newtonian fluids (blood), achieving separation efficiencies of up to 94% and large particles recovery rates of 100%, even at very high flow rates (mL/h).

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Microfluidics with new multi-stage arc-unit structures for size-based cross-flow separation of microparticles

Cited by 7 publications

References 55 publications

Public-Health-Driven Microfluidic Technologies: From Separation to Detection

Public-Health-Driven Microfluidic Technologies: From Separation to Detection

Particles Separation in Microfluidic Devices, Volume II

High throughput clogging free microfluidic particle filter by femtosecond laser micromachining

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