Microgallbladder: Self-Remitting Acute Cholecystitis-Like Condition Unique to Patients with Cystic Fibrosis

Mousa, Mina; Feldman, John; Mahajan, Paresh

doi:10.1155/2019/6737428

Cited by 5 publications

(6 citation statements)

References 26 publications

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“…Micro-gallbladder is associated with CF and rarely with other conditions like a-1 antitrypsin deficiency, idiopathic neonatal hepatitis and biliary atresia. [1][2][3][4] Up to one-third of patients with CF have gallbladderrelated abnormalities. [1][2][3] Chronic calculous cholecystitis may also cause recurrent inflammation and severe fibrosis resulting in atrophy of gallbladder.…”

Section: Discussionmentioning

confidence: 99%

“…Non-visualisation of the gallbladder on initial ultrasound scan raised the suspicion of agenesis or intrahepatic gallbladder; thus an MRCP was carried out to better visualise the biliary tree. 4,5 No repeated episodes of acute cholecystitis leading to fibrosis and contracture of the gallbladder could be justified by her history or from morphology or histopathology of gallbladder specimen.…”

Section: Discussionmentioning

confidence: 99%

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Micro-gallbladder: A rare surgical problem

et al. 2021

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Micro-gallbladder is a rare clinical entity and mostly linked with cystic fibrosis (CF), which is an autosomal recessive disease involving a protein Cystic fibrosis transmembrane conductance regulator (CFTR) which regulates secretion and absorption in the pulmonary, reproductive and gastrointestinal systems including the liver. Biliary secretion becomes hyperviscous, leading to cholestasis and partial obstruction of the cystic duct. This causes recurrent cholecystitis and gallstone formation. Ultimately, atrophy of the gallbladder results, thus a ‘micro-gallbladder’ defined as being <2–3 cm in length and 0.5–1.5 cm in width. A shrunken gallbladder from recurrent attacks of gallstone-induced cholecystitis is not typically termed as a micro-gallbladder. Laparoscopic cholecystectomy is definitive treatment for symptomatic micro-gallbladder, even though most cases are managed conservatively without surgery. We report a case of symptomatic micro-gallbladder in a non-CF patient, managed successfully by laparoscopic cholecystectomy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Micro-gallbladder: A rare surgical problem

et al. 2021

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“…Biliary tract abnormalities can be present at birth, at diagnosis, or subsequently develop in infants and adults 122–125 . Biliary colic may occur in a small number of PwCF on initiation of CFTR modulator therapies 126 .…”

Section: Methodsmentioning

confidence: 99%

“…Biliary tract abnormalities can be present at birth, at diagnosis, or subsequently develop in infants and adults. [122][123][124][125] Biliary colic may occur in a small number of PwCF on initiation of CFTR modulator therapies. [126] Cholecystectomy is generally safe, with conservative preoperative and postoperative pulmonary management.…”

Section: Treatmentmentioning

confidence: 99%

Cystic fibrosis screening, evaluation, and management of hepatobiliary disease consensus recommendations

Sellers,

Assis,

Paranjape

et al. 2023

Hepatology

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Background and Aims Cystic fibrosis (CF) may cause a spectrum of hepatobiliary complications, including portal hypertension, multilobular cirrhosis, and liver failure. Current guidelines on the detection and monitoring of hepatobiliary complications in CF were published in 1999. The CF Foundation assembled a committee to evaluate research advances and formulate revised guidelines for CF-associated liver disease. Approach A committee of hepatologists, gastroenterologists, pulmonologists, pharmacist, nurse, dietitian, individual with CF, and parent of a child with CF devised “population, intervention, comparison, and outcome” (PICO) questions regarding hepatobiliary disease in CF. PubMed literature searches were performed for each PICO question. Recommendations were voted on with 80% agreement required to approve a recommendation. Public comment on initial recommendations was solicited prior to formulation of final recommendations. Results 31 PICO questions were assembled, 6,401 manuscripts were title screened for relevance, with 1,053 manuscripts undergoing detailed full text review. Seven recommendations were approved for screening, 13 for monitoring of existing disease, and 14 for treatment of CF-associated hepatobiliary involvement or advanced liver disease. One recommendation on liver biopsy did not meet the 80% threshold. One recommendation on screening ultrasound was revised and re-voted on. Conclusions Through a multidisciplinary committee and public engagement, we have assembled updated recommendations and guidance on screening, monitoring and treatment of CF-associated hepatobiliary involvement and advanced liver disease. While research gaps remain, we anticipate that these recommendations will lead to improvements in CF outcomes through earlier detection and increased evidence-based approaches to monitoring and treatment.

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“…At US examination, the hypoplastic gallbladder seems to be contracted, collapsed or simply small in size. The microgallbladder, typically associated with cystic fibrosis, is defined as a gallbladder < 2-3 cm long and < 0.5-1.5 wide [196]. -Septated and multiseptated gallbladder.…”

Section: Congenital Variants Of the Gallbladdermentioning

confidence: 99%

New Developments in the Ultrasonography Diagnosis of Gallbladder Diseases

Mencarini,

Vestito,

Zagari

et al. 2024

Gastroenterology Insights

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Gallbladder diseases are very common, and their diagnosis is based on clinical–laboratory evaluation and imaging techniques. Considering the different imaging diagnostic tools, ultrasound (US) has the advantage of high accuracy combined with easy availability. Therefore, when a gallbladder disease is suspected, US can readily assist the clinician in the medical office or the emergency department. The high performance of US in the diagnosis of gallbladder diseases is mainly related to its anatomic location. The most frequent gallbladder pathological condition is gallstones disease, easily diagnosed via US examination. Acute cholecystitis (AC), a possible complication of gallstone disease, can be readily recognized due to its specific sonographic features. Additionally, a number of benign, borderline or malignant gallbladder lesions may be detected via US evaluation. The combined use of standard B-mode US and additional sonographic techniques, such as contrast-enhanced ultrasonography (CEUS), may provide a more detailed study of gallbladder lesions. Multiparametric US (combination of multiple sonographic tools) can improve the diagnostic yield during gallbladder examination.

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Microgallbladder: Self-Remitting Acute Cholecystitis-Like Condition Unique to Patients with Cystic Fibrosis

Cited by 5 publications

References 26 publications

Micro-gallbladder: A rare surgical problem

Micro-gallbladder: A rare surgical problem

Cystic fibrosis screening, evaluation, and management of hepatobiliary disease consensus recommendations

New Developments in the Ultrasonography Diagnosis of Gallbladder Diseases

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