Microgel-Modified Bilayered Hydrogels Dramatically Boosting Load-Bearing and Lubrication

Lin, Peng; Fu, Danni; Zhang, Tingting; Ma, Shuanhong; Zhou, Feng

doi:10.1021/acsmacrolett.3c00398

Cited by 10 publications

(4 citation statements)

References 33 publications

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“…Hence, incorporating stimuli-responsive drug release into lubrication strategies can aid in repairing damaged articular cartilage. In terms of tribological studies, for instance, articular cartilage features a distinctive biphasic structure that incorporates both soft and hard materials to support heavy loads and minimize friction within joints [59,[181][182][183][184]. To mimic this structure, Li et al [59] developed a composite coating consisting of a dual-layer config-uration comprising a thin PTFE layer atop a porous TiO 2 coating on Ti6Al4V alloy, as shown in Figure 11.…”

Section: Self-cleaning Coatingsmentioning

confidence: 99%

Bioinspired and Multifunctional Tribological Materials for Sliding, Erosive, Machining, and Energy-Absorbing Conditions: A Review

Kumar,

Rezapourian,

Rahmani

et al. 2024

Biomimetics

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Friction, wear, and the consequent energy dissipation pose significant challenges in systems with moving components, spanning various domains, including nanoelectromechanical systems (NEMS/MEMS) and bio-MEMS (microrobots), hip prostheses (biomaterials), offshore wind and hydro turbines, space vehicles, solar mirrors for photovoltaics, triboelectric generators, etc. Nature-inspired bionic surfaces offer valuable examples of effective texturing strategies, encompassing various geometric and topological approaches tailored to mitigate frictional effects and related functionalities in various scenarios. By employing biomimetic surface modifications, for example, roughness tailoring, multifunctionality of the system can be generated to efficiently reduce friction and wear, enhance load-bearing capacity, improve self-adaptiveness in different environments, improve chemical interactions, facilitate biological interactions, etc. However, the full potential of bioinspired texturing remains untapped due to the limited mechanistic understanding of functional aspects in tribological/biotribological settings. The current review extends to surface engineering and provides a comprehensive and critical assessment of bioinspired texturing that exhibits sustainable synergy between tribology and biology. The successful evolving examples from nature for surface/tribological solutions that can efficiently solve complex tribological problems in both dry and lubricated contact situations are comprehensively discussed. The review encompasses four major wear conditions: sliding, solid-particle erosion, machining or cutting, and impact (energy absorbing). Furthermore, it explores how topographies and their design parameters can provide tailored responses (multifunctionality) under specified tribological conditions. Additionally, an interdisciplinary perspective on the future potential of bioinspired materials and structures with enhanced wear resistance is presented.

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Section: Self-cleaning Coatingsmentioning

confidence: 99%

Bioinspired and Multifunctional Tribological Materials for Sliding, Erosive, Machining, and Energy-Absorbing Conditions: A Review

Kumar,

Rezapourian,

Rahmani

et al. 2024

Biomimetics

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“…As we explained in the Introduction section, articular cartilage is a type of hyaline cartilage that enables smooth movements between bones in articulating joints, which requires both weight-bearing and low-friction capability [85]. Therefore, the regenerated cartilage requires these high qualities of properties.…”

Section: Cell Sourcesmentioning

confidence: 99%

Glycosphingolipids in Osteoarthritis and Cartilage Regeneration Therapy: Mechanisms and Therapeutic Prospects

Homan,

Onodera,

Matsuoka

et al. 2024

Preprint

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Glycosphingolipids (GSLs), a subtype of glycolipids containing sphingosine, are critical components of vertebrate plasma membranes, playing a pivotal role in cellular signaling and interactions. In human articular cartilage in osteoarthritis (OA), GSL expression is known notably to decrease. This review focuses on the roles of gangliosides, a specific type of GSL, in cartilage degeneration and regeneration, emphasizing their regulatory function in signal transduction. The expression of gangliosides, whether endogenous or augmented exogenously, is regulated at the enzymatic level, targeting specific glycosyltransferases. This regulation has significant implications for the composition of cell surface gangliosides and their impact on signal transduction in chondrocytes and progenitor cells. Different levels of ganglioside expression can influence signaling pathways in various ways, potentially affecting cell properties, including malignancy. Moreover, gene manipulations against gangliosides have been shown to regulate cartilage metabolism and chondrocyte differentiation in vivo and in vitro. This review highlights the potential of targeting gangliosides in the development of therapeutic strategies for osteoarthritis and cartilage injury and addresses promising directions for future research and treatment.

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“…[45,46] The low friction in this hydrogel was attributed to PAMPS' negative charge and BC's swelling control. [47] Moreover, the superior lubrication effect stimulated cartilage regeneration and effectively reverses OA progression after an intraarticular injection into an OA model. The boundary layer of healthy articular cartilage exposes phosphatidylcholine (PC) lipids through cellular replenishment and selfassembly.…”

Section: Hydrogel-mediated Mechanical Modulation Of Oa Jointsmentioning

confidence: 99%

Hydrogels for ameliorating osteoarthritis: Mechanical modulation, anti‐inflammation, and regeneration

Jiang,

Sun,

Lyu

et al. 2024

BMEMat

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Osteoarthritis (OA) is a chronic and degenerative disease with limited clinical options for effective suppression. Recently, significant endeavors have been explored to reveal its pathogenesis and develop treatments against OA. Hydrogels, designed with a striking resemblance to the extracellular matrix, offer a biomimetic interaction with biological tissues, presenting a promising avenue for OA amelioration. As a result, biocompatible hydrogels have been erected incorporating on‐demand bioactivities to optimize the intra‐articular microenvironment, thereby alleviating OA symptoms and fostering the eventual regeneration of articular joints. This review highlights the collaborative objectives underlying the establishment of this tissue microenvironment, encompassing mechanical modulation, anti‐inflammation, and tissue regeneration. Specifically, we consolidate recent advances in hydrogel‐based biomaterials, serving as the tissue engineering scaffolds to replicate the lubrication properties of natural joints or the bioactive agent‐loaded vehicles to combat localized inflammation. Additionally, hydrogels function as cell scaffolds to facilitate the maintenance of cellular homeostasis and contribute to the advancement of cartilage regeneration. Finally, this review outlines the prospective directions for hydrogel‐mediated OA therapies.

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Microgel-Modified Bilayered Hydrogels Dramatically Boosting Load-Bearing and Lubrication

Cited by 10 publications

References 33 publications

Bioinspired and Multifunctional Tribological Materials for Sliding, Erosive, Machining, and Energy-Absorbing Conditions: A Review

Bioinspired and Multifunctional Tribological Materials for Sliding, Erosive, Machining, and Energy-Absorbing Conditions: A Review

Glycosphingolipids in Osteoarthritis and Cartilage Regeneration Therapy: Mechanisms and Therapeutic Prospects

Hydrogels for ameliorating osteoarthritis: Mechanical modulation, anti‐inflammation, and regeneration

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