Microgel–silica hybrid particles: Strategies for tunable nanostructure, composition, surface property and porphyrin functionalization

Li, Xiaoqing; Yuan, Jianjun; Liu, Huan; Jiang, Lei; Sun, Shuqing; Chen, Shiyuan

doi:10.1016/j.jcis.2010.04.066

Cited by 14 publications

(6 citation statements)

References 52 publications

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“…It was noted that, as the time of reaction increased, the average hydrodynamic size of the hybrid particles at 25 °C decreased instead. A similar inverse relationship between silica deposition time and size of MG-silica hybrid particles based on DLS was reported by Li et al 33 At the first glance, this outcome was counterintuitive, as one would expect a longer reaction time resulting in growth of silica and thus formation of larger particles. To explain this observation, one should bear in mind the presumable function of the template by MGs for the growth of silica, and in return, hydration of the formed hybrid particles in water needs to take into consideration the interactions between silica and the polymeric chains.…”

Section: ■ Results and Discussionsupporting

confidence: 70%

Silicification of Amine-Epoxide Cationic Microgels: An In Vitro Investigation

Sun

Cheng

2021

Langmuir

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Herein, the applicability of an unconventional, non-vinylic type of amine-epoxide microgels (MGs) to promote silica deposition from tetraethyl orthosilicate (TEOS) was investigated. Simply mixing MGs with TEOS in water at 25 °C resulted in the formation of hybrid silica-MG particles (sMGs) as a function of silicification time. The sMGs were cationic with thermal-sensitive swelling capability. Extending silicification time to 24 h was shown to increase silica content to 43%. Besides, the sMGs became structurally more rigid to resist drying-induced deformation and exhibited a rugged surface texture. Mechanistically, the aminated nature of the MGs was proved beneficial for the success of their silicification, fulfilling dual functions of the catalyst for TEOS hydrolysis and template for silica deposition. Through electrostatic adsorption, the sMGs provided a facile yet robust option for surface modifications toward bone-related applications. Surface-induced mineralization in simulated biological fluids was observed with sMG-immobilized surfaces, where the presence of hydroxyapatite was characterized in the deposited apatite. In vitro MC3T3-E1 pre-osteoblast cell studies showed that cell adhesion, morphology, and proliferation could be influenced by both sMG types and their adsorption density. Of particular interest is the finding of cells exhibiting elongated and greatly polarized morphology on the surface with high adsorption density of sMGs of 43% silica. It was postulated that the rugged appearance of such sMGs could have presented a hierarchically structured surface toward cells, an interesting aspect to be further exploited for the engineering of cell−surface interactions.

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Section: ■ Results and Discussionsupporting

confidence: 70%

Silicification of Amine-Epoxide Cationic Microgels: An In Vitro Investigation

Sun

Cheng

2021

Langmuir

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“…5,–7 This improvement is due to the versatility of silica and beneficial material properties associated with the sensor morphology, such as optical transparency, mechanical stability, chemical roughness, and flexibility. 7,–9 In addition, this type of matrix is permeable to analytes, while keeping the receptor element inside. This process also allows researchers to tune the matrix characteristics with respect to the final application.…”

Section: Introductionmentioning

confidence: 99%

Determination of the Network Structure of Sensor Materials Prepared by Three Different Sol-Gel Routes Using Fourier Transform Infrared Spectroscopy (FT-IR)

et al. 2013

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Solid acid-base sensor materials were prepared by encapsulating three pH indicators (alizarin red, brilliant yellow, and acridine) within a silica matrix using a sol-gel approach through three different routes: (1) non-hydrolytic, (2) acid-catalyzed, and (3) base-catalyzed. Raman and Fourier transform infrared spectroscopies were used to evaluate the silica-indicator interactions. Because vibrational bands assigned to functional groups present in the indicator molecules were not detected, the main silica stretching mode νSi-O between approximately 1300 and 1000 cm(-1) was used to detect the presence of our indicators within the silica matrix. The large band centered at 1100 cm(-1) was deconvoluted into four components corresponding to the longitudinal optic and transversal optic modes of the silicon monoxide (SiO)4 and (SiO)6 siloxane rings. Using the component area of each mode, it was possible to calculate the percentage of each structure. Such percentages ranged from 49% to 70% (SiO)6 for the analyzed samples, within a confidence level of 95% (p = 0.05). (The confidence limits were 53-62%.) These results could be related to the pH indicator content, indicating that the quantity of the encapsulated molecule affects the (SiO)6 percentage values. In addition, a comparison with the radius of gyration obtained by small angle X-ray scattering was done. These results indicate that the analyte accesses the receptor elements through the passages between the siloxane rings but not through the siloxane rings themselves.

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“…Nanoparticles with core-shell structure in which the shell is formed exclusively by silica have a zeta potential curve similar to the curve of silica nanoparticles and an IEP around 2.0 [47,48]. The IEP of BS1, BS2, BS3 and BS4 nanoparticles is lower than the IEP of BSA-NP and higher than that of silica, so it seems reasonable to assume that silica and BSA are present on the surface of these nanoparticles and the proportion of these materials determines the IEP of each sample [25,49]. The zeta potential curve of BS4 nanoparticles is similar to that of BSA-NP nanoparticles, also their IEP are slightly similar.…”

Section: Resultsmentioning

confidence: 99%

Protein-Silica Hybrid Submicron Particles: Preparation and Characterization

et al. 2020

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Purpose Hybrid nanoparticles are an interesting type of particles currently employed in nanomedicine. They can combine the therapeutic and diagnostic functions of their components into one single nanosystem and therefore, can be tweaked according to their applications and desired results. The purpose of this work is to develop an easily tuned nano-system of bovine serum albumin-silica hybrid nanoparticles. Methods BSA nanoparticles were prepared by nanoprecipitation process using water as the solvent phase and ethanol as the non-solvent. Silica was produced through a sol-gel process and deposited inside the BSA nanoparticles via template deposition. The effect of initial concentrations of raw materials on the structure and colloidal properties of the system was evaluated using FTIR, TGA, TEM, and zeta potential measurements. Results A hybrid structure of BSA-silica was obtained. The results suggest that the particles size, isoelectric point and silica content of the hybrid nanoparticles can be easily tuned by controlling adequately the concentration of TEOS and ammonia. Conclusion Our method can be considered as a novel approach for hybrid nanoparticle synthesis. To our knowledge, we report for the first time the synthesis of silica-BSA hybrid particles with a non-core-shell structure. In addition, we proved that that the particles size, isoelectric point and silica content of the hybrid nanoparticles can be easily tuned by controlling adequately the concentration of TEOS and ammonia.

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Microgel–silica hybrid particles: Strategies for tunable nanostructure, composition, surface property and porphyrin functionalization

Cited by 14 publications

References 52 publications

Silicification of Amine-Epoxide Cationic Microgels: An In Vitro Investigation

Silicification of Amine-Epoxide Cationic Microgels: An In Vitro Investigation

Determination of the Network Structure of Sensor Materials Prepared by Three Different Sol-Gel Routes Using Fourier Transform Infrared Spectroscopy (FT-IR)

Protein-Silica Hybrid Submicron Particles: Preparation and Characterization

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