Microgels in biomaterials and nanomedicines

Wang, Yitong; Guo, Luxuan; Dong, Shuli; Cui, Jiwei; Hao, Jingcheng

doi:10.1016/j.cis.2019.01.005

Cited by 67 publications

(38 citation statements)

References 209 publications

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“…Microgels are microparticles consisting of a network of crosslinked macromolecules (Plamper & Richtering, 2017;Wang, Guo, Dong, Cui, & Hao, 2019). Due to their swelling and de-swelling behavior upon changes of the environmental conditions, they can be used to encapsulate bioactive compounds and control their release (Bysell, Mansson, Hansson, & Malmsten, 2011).…”

Section: Introductionmentioning

confidence: 99%

pH and ionic strength responsive core-shell protein microgels fabricated via simple coacervation of soy globulins

et al. 2020

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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Section: Introductionmentioning

confidence: 99%

pH and ionic strength responsive core-shell protein microgels fabricated via simple coacervation of soy globulins

et al. 2020

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“…This last stage aimed to develop the so called "smart hydrogels" with a variety of possible applications. Hybrid hydrogels based on both natural and synthetic polymers offer infinite possibility to cells encapsulation, as matrices for repairing and regenerating a wide variety of tissues and organs [115], are capable of responding to biological signals in vivo or remote triggers and other many possible applications in biomaterials, biomedicine and nanomedicine [116].…”

Section: Applicationsmentioning

confidence: 99%

New Developments in Medical Applications of Hybrid Hydrogels Containing Natural Polymers

Vasile¹,

Pamfil²,

Stoleru³

et al. 2020

Molecules

210

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New trends in biomedical applications of the hybrid polymeric hydrogels, obtained by combining natural polymers with synthetic ones, have been reviewed. Homopolysaccharides, heteropolysaccharides, as well as polypeptides, proteins and nucleic acids, are presented from the point of view of their ability to form hydrogels with synthetic polymers, the preparation procedures for polymeric organic hybrid hydrogels, general physico-chemical properties and main biomedical applications (i.e., tissue engineering, wound dressing, drug delivery, etc.).

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“…A person who leaves with diabetes demands continuous glycemic control. Usually, these patients are treated with palliative self-injections of insulin that are not accurate according to their daily glycemic levels and impair their quality of life [ 5 , 84 , 85 ]. Matsumoto and colleagues developed a smart copolymer microgel system that responds to the presence of glucose such as an artificial pancreas.…”

Section: Microgelsmentioning

confidence: 99%

“…The degeneration of the articular cartilage and the synovial fluid due to age and other factors raises the need for alternative treatments since the self-repair of cartilage is a very difficult process owed to the low quantity of blood vessels in it. Microgels stand out in this application when compared to macrogels because of their higher mechanical properties combined with good lubrication and rheology, besides the capacity of loading drugs and stimuli responsiveness [ 84 ]. Biolubricants also may be used in the eyes, oral cavity, and gastrointestinal tract, among other applications in order to minimize discomfort.…”

Section: Microgelsmentioning

confidence: 99%

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An Updated Review of Macro, Micro, and Nanostructured Hydrogels for Biomedical and Pharmaceutical Applications

et al. 2020

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Hydrogels are materials with wide applications in several fields, including the biomedical and pharmaceutical industries. Their properties such as the capacity of absorbing great amounts of aqueous solutions without losing shape and mechanical properties, as well as loading drugs of different nature, including hydrophobic ones and biomolecules, give an idea of their versatility and promising demand. As they have been explored in a great number of studies for years, many routes of synthesis have been developed, especially for chemical/permanent hydrogels. In the same way, stimuli-responsive hydrogels, also known as intelligent materials, have been explored too, enhancing the regulation of properties such as targeting and drug release. By controlling the particle size, hydrogel on the micro- and nanoscale have been studied likewise and have increased, even more, the possibilities for applications of the so-called XXI century materials. In this paper, we aimed to produce an overview of the recent studies concerning methods of synthesis, biomedical, and pharmaceutical applications of macro-, micro, and nanogels.

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Microgels in biomaterials and nanomedicines

Cited by 67 publications

References 209 publications

pH and ionic strength responsive core-shell protein microgels fabricated via simple coacervation of soy globulins

pH and ionic strength responsive core-shell protein microgels fabricated via simple coacervation of soy globulins

New Developments in Medical Applications of Hybrid Hydrogels Containing Natural Polymers

An Updated Review of Macro, Micro, and Nanostructured Hydrogels for Biomedical and Pharmaceutical Applications

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