Microgels in Drug Delivery

Supramolecular Polymer Networks: Preparation, Properties, and Potential

“…They find multiple applications in drug delivery [286], biosensing [287], catalysis [288], and regenerative medicine [289]. Microgels are particularly useful for the encapsulation of living cells, because the microgel matrix can mimic the natural extracellular matrix very well and because microgel particles can be handled very easily by syringes and pipettes and are injectable [290].…”

Contrast variation SANS measurement of shell monomer density profiles of smart core–shell microgels

“…[1][2][3][4][5][6][7][8][9][10] This behaviour grants them the adjective smart. The response of these materials has great potential in the context of different applications like smart catalyst carriers, [11][12][13] drug delivery, 14,15 sensors, [16][17][18] optical devices, [19][20][21] responsive surface coatings 22 and actuators 23 or in biomedical applications. 24 Combining two monomers of different transition temperatures in statistical copolymers can be used to tune the swelling transition temperature, [25][26][27][28][29] whereas the subsequent synthesis of core and then shell 27,30-35 may lead to a continuous, linear temperature dependent swelling.…”

A New Era of Cardiac Cell Therapy: Opportunities and Challenges

“…They are notable for their potentials as delivery vehicles of small molecules and proteins (Figure 7). [158] Poly( N- isopropylacrylamide) nanogels were engineered as part of a dual-delivery system to reopen the clotted blood vessels and inhibit fibrosis during post-MI heart remodeling by targeting the deposited fibrin. [65] In the study, tissue plasminogen activator and a small-molecule cell contractility inhibitor (Y-27632) were encapsulated inside the nanogels.…”