Microginins, Zinc Metalloproteases Inhibitors from the Cyanobacterium Microcystis aeruginosa

Ishida, Keishi; Kato, Taku; Murakami, Masahirô; Watanabe, Masayuki; Watanabe, Mariyo F.

doi:10.1016/s0040-4020(00)00770-5

Cited by 78 publications

(92 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[28] and low when compare with P. thonningii 35.03 [21] but are higher than that of Gnetum africanum (4.60), M. ureans (4.00) and Parinari polyandra. The plants are good source of crude fibre when consumed because adequate intake of dietary fibre can lower the serum cholesterol level, heart disease, hypertension, constipation, diabetes and breast cancer [32].…”

Section: Resultsmentioning

confidence: 99%

Phytochemical and Proximate Analysis of Some Medicinal Leaves

Aborisade¹

2017

CMR

View full text Add to dashboard Cite

Abstract:The proximate analysis and the phytochemical constituents were investigated in Magnifera, Morinda lucida, Parquetina nigrescens, Oscmium gratissimum, Chenopodium ambrosioides and Veronia amygaldalina using standard reference methods. The proximate analysis in % showed that Chenopodium ambrosioides had the highest amount of ash content of 17.30 and moisture content of 89.40 while Magnifera indica had the lowest amount of ash content 12.04 and moisture content 68.40. Veronia amygaldalina had the highest amount of protein 30.02 and carbohydrate 54.00 while Parquetina nigrescens had the least amount of protein 25.06 and carbohydrate 40.23. Parquetina nigrescens had the highest amount of crude fibre of 25.05 while Chenopodium ambrosioides had the highest amount of crude fat 18.22. The moisture content was found to be 89.40%, ash content 17.30, fat 18.22%, protein 30.02%, crude fibre 25.05% and carbohydrate 54.00%. The phytochemical constituents indicated flavonoid 28.58% alkaloid 25.84% and tannin 2.94% in Magnifera indica, Veronia amygaldalina and Morinda lucida respectively. The presence of high secondary metabolites in the leaves are good indication that if the plant is subjected to further research such as identification and characterization of plant, bioactive compounds with strong biological activities may be isolated and novel compounds may also be identified.

show abstract

Section: Resultsmentioning

confidence: 99%

Phytochemical and Proximate Analysis of Some Medicinal Leaves

Aborisade¹

2017

CMR

View full text Add to dashboard Cite

show abstract

“…Paclitaxel (Taxol) and docetaxel (Taxotere) are currently amongst the most effective clinically available chemotherapeutic agents for the treatment of cancer, and particularly ovarian and breast cancers [2][3][4][5][6]. Representative examples further include the aminopeptidase inhibitors bestatin [7,8] and amastatin [9] and an angiotensin-converting enzyme (ACE) inhibitor, microginin [10,11].…”

Section: Introductionmentioning

confidence: 99%

Syntheses of Hydroxylated Cyclic β-Amino Acid Derivatives

Palkó

Kiss²,

Fülöp

2005

CMC

View full text Add to dashboard Cite

This review is intended to give a short summary of the developments in the field of natural and synthetic alicyclic and heterocyclic hydroxylated beta-amino acids and to focus on the main strategies that have been reported for their synthesis. Given the medicinal and biological significance of the hydroxylated beta-amino acids, an increasing volume of research is currently being directed toward regio-, stereo- and enantioselective access to this class of compounds.

show abstract

“…Microginin-565 presented a structure with terminals Ahda and Tyr moieties and exhibited IC 50 within 6.8-13.2 μM which is a benchmark for potent ACEinhibitory drugs (Ishida et al 2000). The M r of the purified microginin and its fragmentation pattern matched with another tetrapeptide, microginin-FR11 isolated from Microcystis sp.…”

Section: Discussionmentioning

confidence: 95%

“…Treatment with angiotensin-converting enzyme (ACE) antagonists reduced the risk of poststroke death (Heeley et al 2014). Microginins (n =40) are the β-amino-α-hydroxydecanoic acid (Ahda)-containing linear cyanopeptides that inhibit ACE activity due to characteristic terminals Ahda and Tyr moieties (Ishida et al 2000).…”

Section: Introductionmentioning

confidence: 99%

An angiotensin-converting enzyme-inhibitory metabolite with partial structure of microginin in a cyanobacterium Anabaena fertilissima CCC597, producing fibrinolytic protease

Bagchi

Sondhia

Agrawal³

et al. 2015

J Appl Phycol

View full text Add to dashboard Cite

Whole cell matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry (MALDI-TOF MS) of Anabaena fertilissima CCC597 revealed the presence of a microginin (M r =565 Da), which was purified using ODS C18 solid-phase extraction followed by quaternary methyl ammonium (QMA)-ion exchange and reverse-phase liquid chromatography. Its partial structure was deduced upon LC-MS/MS as β-amino-α-hydroxy-decanoic acid-Ala-MeLeuTyr. Microginin-565 inhibited rabbit angiotensin-converting enzyme activity at an apparent IC 50 =9.8 μM.

show abstract

Microginins, Zinc Metalloproteases Inhibitors from the Cyanobacterium Microcystis aeruginosa

Cited by 78 publications

References 41 publications

Phytochemical and Proximate Analysis of Some Medicinal Leaves

Phytochemical and Proximate Analysis of Some Medicinal Leaves

Syntheses of Hydroxylated Cyclic β-Amino Acid Derivatives

An angiotensin-converting enzyme-inhibitory metabolite with partial structure of microginin in a cyanobacterium Anabaena fertilissima CCC597, producing fibrinolytic protease

Contact Info

Product

Resources

About