Microglia activation in the extremely preterm human brain

Supramaniam, Veena; Vontell, Regina; Srinivasan, Latha; Wyatt-Ashmead, Josephine; Hagberg, Henrik; Rutherford, Mary A.

doi:10.1038/pr.2012.186

Cited by 72 publications

(57 citation statements)

References 39 publications

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“…Preterm isolated GMH/IVH with no overt venous parenchymal infarction (as evidenced by postmortem MRI), showed increased microglial activation, cell apoptosis and axonal injury in the periventricular white matter [23]. These results suggest that minor isolated GMH in the preterm brain may still result in deleterious effect on the adjacent white matter through microglial activation.…”

Section: Preterm Germinal Matrix/intraventricular Heamorrhagementioning

confidence: 73%

Microglia toxicity in preterm brain injury

Baburamani

Supramaniam

Hagberg

et al. 2014

Reproductive Toxicology

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Section: Preterm Germinal Matrix/intraventricular Heamorrhagementioning

confidence: 73%

Microglia toxicity in preterm brain injury

Baburamani

Supramaniam

Hagberg

et al. 2014

Reproductive Toxicology

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“…Furthermore, the deleterious effects of haemosiderin on other developing regions of the brain have been demonstrated. Ependymal depositions of haemosiderin in the lateral ventricles resulting from GMH-IVH may trigger inflammation in the adjacent periventricular white matter via activation of increased number of microglia 25 26…”

Section: Discussionmentioning

confidence: 99%

Accuracy of ultrasound in assessing cerebellar haemorrhages in very low birthweight babies

Parodi

Rossi

Severino

et al. 2015

Arch Dis Child Fetal Neonatal Ed

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“…Iba-1 is a well-established marker for microglia in many mammalian species, including humans (51, 52), and both cell bodies and processes of microglia are strongly immunoreactive for Iba-1. When activated, the cell body enlarges and becomes more strongly immunoreactive for CD68, and the processes become shorter and thicker (53-55). With double labeling, both of these features are apparent, thereby facilitating classification (56, 57).…”

Section: Methodsmentioning

confidence: 99%

Microglia of Prefrontal White Matter in Suicide

Schnieder

Trencevska

Rosoklija

et al. 2014

J Neuropathol Exp Neurol

165

120

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Immune functions in the brain are associated with psychiatric illness and with temporary alteration of mental state. Microglia, the principal brain immunological cells, respond to changes in the internal brain milieu through a sequence of activated states, each with characteristic function and morphology. To assess a possible association of frontal white matter pathology with suicide, autopsy brain tissue samples from 11 suicide and 25 non-suicide subjects were stained for ionized calcium-binding adapter molecule 1 (Iba-1), CD68, and myelin. Groups were matched by age, sex, and psychiatric diagnosis. We classified Iba-1-immunoreactive cells on the basis of shape, immunoreactivity for CD68, and association with blood vessels to obtain stereologic estimates of densities of resting microglia, activated phagocytes, and perivascular cells. We found no effect of psychiatric diagnosis but 2 statistically significant effects of suicide: 1) the dorsal-ventral difference in activated microglial density was reversed such that with suicide, the density was greater in ventral than in dorsal prefrontal white matter, whereas in the absence of suicide, the opposite was true; and 2) with suicide there was a greater density of Iba-1-immunoreactive cells within or in contact with blood vessel walls in dorsal prefrontal white matter. These observations could reflect a mechanism for the stress/diathesis (state/trait) model of suicide whereby an acute stress activates a reactive process in the brain, either directly or by compromising the blood-brain barrier, and creates a suicidal state in an individual at risk. They also indicate the theoretical potential of imaging studies in live, vulnerable individuals for the assessment of suicide risk. Further studies are needed to investigate specific phenotypes of perivascular cells and blood-brain barrier changes associated with suicide.

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Microglia activation in the extremely preterm human brain

Cited by 72 publications

References 39 publications

Microglia toxicity in preterm brain injury

Microglia toxicity in preterm brain injury

Accuracy of ultrasound in assessing cerebellar haemorrhages in very low birthweight babies

Microglia of Prefrontal White Matter in Suicide

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