2024
DOI: 10.3389/fphys.2024.1332355
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Microglial reactivity in brainstem chemosensory nuclei in response to hypercapnia

Jaime Eugenín,
Sebastián Beltrán-Castillo,
Estefanía Irribarra
et al.

Abstract: Microglia, the resident immune cells of the CNS, surveil, detect, and respond to various extracellular signals. Depending on the nature of these signals, an integrative microglial response can be triggered, resulting in a phenotypic transformation. Here, we evaluate whether hypercapnia modifies microglia phenotype in brainstem respiratory-related nuclei. Adult C57BL/6 inbred mice were exposed to 10% CO2 enriched air (hypercapnia), or pure air (control), for 10 or 30 min and immediately processed for immunohist… Show more

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