Microgramma vacciniifolia frond lectin (MvFL) exhibits antitumor activity against sarcoma 180 in mice

Patriota, Leydianne Leite de Siqueira; Ramos, Dalila de Brito Marques; Silva, Yasmym Araújo; Santos, Angela Caroline Lima Amorim dos; Araújo, Maria Taís de Moura Fontes; Brito, Jéssica de Santana; Torres, Diego José Lira; Oliveira, Alisson Macário de; Silva, Diego César Nunes da; Lorena, Virgínia Maria Barros de; Paiva, Patrícia Maria Guedes; Mendes, Rosemairy Luciane; Napoleão, Thiago Henrique

doi:10.1016/j.phyplu.2020.100013

Cited by 7 publications

(3 citation statements)

References 18 publications

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“…Due to this heterogeneity, cancer treatment is still fraught with limitations. Cytotoxic chemotherapy, one of the main forms of treatment, is limited by cell resistance to drugs, in addition to causing many adverse side effects (Patriota et al, 2021, Lin et al, 2020, Petrović et al, 2020. Thus, tumors are highly adaptable, as they can activate resistance signaling routes and inactivate the death signaling cascade, leading to resistance to treatment.…”

Section: Introductionmentioning

confidence: 99%

Genipa americana lectin (GaBL) induces inhibition of growth, migration, invasion, and regulation of the expression of caspase-mediated apoptosis and proteins related to the development of cancer in human head and neck cells

Costa,

Silva,

Gomes

et al. 2024

Preprint

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The antitumor activity of Genipa americana bark lectin (GaBL) was evaluated for the first time against cell lines of human skin cancer (A431), melanoma (B16), and squamous cell carcinoma of the tongue (SCC9). Cancer cell lines were treated with 10 µg/ml of GaBL to assess cell viability, cell migration and invasion, as well as the identification of cell membrane alterations associated with apoptosis. Real-time polymerase chain reaction for caspase-3 was performed to verify if apoptosis is activated by lectin treatment. The mRNA expression of proteins (E-cadherin, type I collagen) related to the epithelial-mesenchymal transition was also analyzed. GaBL decreased (27.5–50%) cell proliferation and reduced cell migration in all strains evaluated. Additionally, the lectin decreased the invasion of SCC9 cells. Apoptosis was higher against B16 and SCC9 cells treated with the lectin. GaBL induced the upregulation of caspase-3, E-cadherin and suppression of type I collagen in all strains tested, indicating lower cancer development. GaBL induces inhibition of growth, migration, invasion, and regulation of the expression of caspase-mediated apoptosis and proteins related to the development of cancer in human head and neck cells.

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Section: Introductionmentioning

confidence: 99%

Genipa americana lectin (GaBL) induces inhibition of growth, migration, invasion, and regulation of the expression of caspase-mediated apoptosis and proteins related to the development of cancer in human head and neck cells

Costa,

Silva,

Gomes

et al. 2024

Preprint

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show abstract

“…Some lectins have stood out for their in vitro cytotoxic effects against tumor cell lines, in vivo antitumor action, and helping roles in the diagnosis and monitoring of cancer progression and evolution [2,6,16,17]. Lectins can specifically recognize changes in glycosylation patterns in tumor cell membranes, triggering effective responses, such as activation of cell death and tumor growth inhibition mechanisms [2,18].…”

Section: Introductionmentioning

confidence: 99%

Effects of Lectins from Alpinia purpurata Inflorescence (ApuL) and Schinus terebinthifolia Leaf (SteLL) on Human Leukemic Cell Lines and Mesenchymal Stem Cells

et al. 2023

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Lectins (carbohydrate-binding proteins) are able to distinguish different patterns of glycosylation on cell surfaces. This study investigated the effects of lectins from Alpinia purpurata inflorescence (ApuL) and Schinus terebinthifolia leaf (SteLL) on the viability of human leukemia cells (K562, chronic myeloid leukemia; JURKAT, acute lymphoblastic leukemia) and mesenchymal stem cells (MSCs) from human umbilical cords. In addition, possible immunomodulatory effects of ApuL and SteLL on MSCs were assessed by determining cytokine levels in cultures. ApuL reduced the viability of JURKAT cells (IC50: 12.5 μg/mL), inducing both apoptosis and necrosis. For K562 cells, ApuL at 50 µg/mL caused a decrease in viability, but of only 8.8%. Conversely, SteLL exerted a cytotoxic effect on K562 (IC50: 6.0 μg/mL), inducing apoptosis, while it was not cytotoxic to JURKAT. ApuL and SteLL (0.19–100 μg/mL) did not decrease MSCs viability. Treatment with ApuL strongly suppressed (99.5% reduction) the release of IL-6 by MSCs. SteLL also reduced the levels of this cytokine in culture supernatant. In conclusion, ApuL and SteLL showed potential to reduce the viability of leukemia cells, as well as immunomodulatory effect on MSCs without being toxic to them. These biological properties can be explored biomedically and biotechnologically in the future.

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“…The rhizome of M. vacciniifolia contains a lectin called MvRL. Lectins are carbohydrate-binding proteins that are broadly found in plants and possess several biological activities, including antimicrobial ( Almeida et al., 2020 ) and anticancer ( Patriota et al., 2021 ) properties. MvRL showed antifungal activity against Fusarium oxysporum f. sp.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and antitumor activities of a lectin-rich preparation from Microgramma vacciniifolia rhizome

Silva

Oliveira

Costa

et al. 2022

Current Research in Pharmacology and Drug Discovery

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Microgramma vacciniifolia frond lectin (MvFL) exhibits antitumor activity against sarcoma 180 in mice

Cited by 7 publications

References 18 publications

Genipa americana lectin (GaBL) induces inhibition of growth, migration, invasion, and regulation of the expression of caspase-mediated apoptosis and proteins related to the development of cancer in human head and neck cells

Genipa americana lectin (GaBL) induces inhibition of growth, migration, invasion, and regulation of the expression of caspase-mediated apoptosis and proteins related to the development of cancer in human head and neck cells

Effects of Lectins from Alpinia purpurata Inflorescence (ApuL) and Schinus terebinthifolia Leaf (SteLL) on Human Leukemic Cell Lines and Mesenchymal Stem Cells

Antibacterial and antitumor activities of a lectin-rich preparation from Microgramma vacciniifolia rhizome

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