The International Space Station (ISS) National Laboratory provides an ideal platform in persistent microgravity to conduct research in the absence of gravity-induced phenomena (e.g., buoyancy-driven convection and sedimentation), enabling opportunities for breakthrough science. Since 2016, the U.S. National Science Foundation (NSF) Chemical, Bioengineering, Environmental, and Transport Systems (CBET) Division has partnered with the Center for the Advancement of Science in Space™ (CASIS™), manager of the ISS National Lab, to release an annual joint solicitation in transport phenomena research on the ISS to benefit life on Earth. To date, the NSF-CASIS partnership has yielded 37 NSF-funded research investigations sponsored by the ISS National Lab. This paper highlights a few of the important scientific discoveries that have resulted from the fruitful NSF-CASIS collaboration and offers insight into the importance of expanding collaborations between government agencies to increase access to space and enable groundbreaking research that benefits humanity. Research areas explored include biophysics, combustion, complex fluids, fluid dynamics, heat transfer and multiphase flow, and materials science.