Microhardness and microstructural properties of a mixture of hydroxyapatite and <i>β</i>-tricalcium phosphate

Lee, Se Woong; Kim, Yurian; Rho, Hyung Tay; Kim, Sang‐il

doi:10.1080/21870764.2022.2136261

Cited by 5 publications

(1 citation statement)

References 26 publications

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“…The XRD pattern of the Ti/oxide/alendronate sample after immersion in artificial sa liva solution contains characteristic peaks for hydroxyapatite (HAp, JCPDS # 00-009-0432 [53] and beta-tricalcium phosphate (β-TCP, JCPDS # 00-009-0169) [21,63], (Figure 6b,c) The peaks of the titanium substrate are also visible. The results are in accordance with the ATR-FTIR results.…”

Section: Experimental Evidence For the Spontaneous Formation Of Calci...mentioning

confidence: 99%

Alendronate as Bioactive Coating on Titanium Surfaces: An Investigation of CaP–Alendronate Interactions

Despotović,

Petrović,

Katić

et al. 2024

Materials

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The surface modification of dental implants plays an important role in establishing a successful interaction of the implant with the surrounding tissue, as the bioactivity and osseointegration properties are strongly dependent on the physicochemical properties of the implant surface. A surface coating with bioactive molecules that stimulate the formation of a mineral calcium phosphate (CaP) layer has a positive effect on the bone bonding process, as biomineralization is crucial for improving the osseointegration process and rapid bone ingrowth. In this work, the spontaneous deposition of calcium phosphate on the titanium surface covered with chemically stable and covalently bound alendronate molecules was investigated using an integrated experimental and theoretical approach. The initial nucleation of CaP was investigated using quantum chemical calculations at the density functional theory (DFT) level. Negative Gibbs free energies show a spontaneous nucleation of CaP on the biomolecule-covered titanium oxide surface. The deposition of calcium and phosphate ions on the alendronate-modified titanium oxide surface is governed by Ca2+–phosphonate (-PO3H) interactions and supported by hydrogen bonding between the phosphate group of CaP and the amino group of the alendronate molecule. The morphological and structural properties of CaP deposit were investigated using scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray diffraction and attenuated total reflectance Fourier transform infrared spectroscopy. This integrated experimental–theoretical study highlights the spontaneous formation of CaP on the alendronate-coated titanium surface, confirming the bioactivity ability of the alendronate coating. The results provide valuable guidance for the promising forthcoming advancements in the development of biomaterials and surface modification of dental implants.

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Section: Experimental Evidence For the Spontaneous Formation Of Calci...mentioning

confidence: 99%

Alendronate as Bioactive Coating on Titanium Surfaces: An Investigation of CaP–Alendronate Interactions

Despotović,

Petrović,

Katić

et al. 2024

Materials

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Preparation and evaluation of osteoinductive porous biphasic calcium phosphate granules obtained from eggshell for bone tissue engineering

Hsu

et al. 2023

Advanced Powder Technology

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Magnesium-enhanced porous hydroxyapatite ceramics: Morphometric parameters, physical properties and bioactivity

Sopyan,

Toibah,

Ramesh

et al. 2024

Ceramics International

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Microhardness and microstructural properties of a mixture of hydroxyapatite and β-tricalcium phosphate

Cited by 5 publications

References 26 publications

Alendronate as Bioactive Coating on Titanium Surfaces: An Investigation of CaP–Alendronate Interactions

Alendronate as Bioactive Coating on Titanium Surfaces: An Investigation of CaP–Alendronate Interactions

Preparation and evaluation of osteoinductive porous biphasic calcium phosphate granules obtained from eggshell for bone tissue engineering

Magnesium-enhanced porous hydroxyapatite ceramics: Morphometric parameters, physical properties and bioactivity

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