Microheater platform for selective detachment of DNA

Javed, Annas; Iqbal, Samir M.; Jain, Ankur

doi:10.1063/1.4748308

Cited by 12 publications

(13 citation statements)

References 18 publications

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“…The dependence agrees with a past report. 26 This result indicates that local temperature is controllable with applied power up to more than 100 C. As shown in Fig. 2(c), difference between temperatures at heating times of 1 and 20 s is small.…”

mentioning

confidence: 51%

High speed DNA denaturation using microheating devices

et al. 2013

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mentioning

confidence: 51%

High speed DNA denaturation using microheating devices

et al. 2013

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“…Our experiments are based on a self-assembled monolayer of amine groups on the cathode surface, and plasma treatment of the separator. Amine groups are commonly used for functionalizing glass surfaces with DNA and other biomolecules [26,27]. Plasma treatment of the separator is motivated by well-known enhancement of surface adhesion of polymers and other materials caused by plasma treatment [38,39].…”

Section: Tcr Enhancementmentioning

confidence: 99%

“…Dominance of the TCR shows that improving thermal conductivity of electrode or separator is unlikely to result in significant enhancement in overall thermal performance. We demonstrate 4X improvement in TCR by chemically bridging the interface with amine chemistry [23,26,27] without affecting electrochemical performance of the cell. This improvement is expected to result in more than 3X improvement in cell-level thermal conductivity and 60% reduction in peak temperature rise during cell operation at 7C discharge rate.…”

Section: Introductionmentioning

confidence: 97%

Heat transfer enhancement in a lithium-ion cell through improved material-level thermal transport

Vishwakarma

Waghela

et al. 2015

Journal of Power Sources

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h i g h l i g h t sIdentifies rate-limiting material-level thermal conduction process in a Li-ion cell. Shows that interfacial thermal conduction between cathode and separator contributes 88% of total thermal resistance. Experimental data agrees with theoretical model on thermal contact resistance. Chemical bridging of this interface results in 4X reduction in thermal contact resistance. Results may contribute towards thermal safety of Li-ion cells. a b s t r a c tWhile Li-ion cells offer excellent electrochemical performance for several applications including electric vehicles, they also exhibit poor thermal transport characteristics, resulting in reduced performance, overheating and thermal runaway. Inadequate heat removal from Li-ion cells originates from poor thermal conductivity within the cell. This paper identifies the rate-limiting material-level process that dominates overall thermal conduction in a Li-ion cell. Results indicate that thermal characteristics of a Liion cell are largely dominated by heat transfer across the cathode-separator interface rather than heat transfer through the materials themselves. This interfacial thermal resistance contributes around 88% of total thermal resistance in the cell. Measured value of interfacial resistance is close to that obtained from theoretical models that account for weak adhesion and large acoustic mismatch between cathode and separator. Further, to address this problem, an amine-based chemical bridging of the interface is carried out. This is shown to result in in four-times lower interfacial thermal resistance without deterioration in electrochemical performance, thereby increasing effective thermal conductivity by three-fold. This improvement is expected to reduce peak temperature rise during operation by 60%. By identifying and addressing the material-level root cause of poor thermal transport in Li-ion cells, this work may contributes towards improved thermal performance of Li-ion cells.

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“…Temperature gradient based devices have been used in the past for controlling attachment between Deoxyribonucleic acid (DNA) and glass, cellular thermotaxis, etc. 12,13 In the present work, bubbles nucleated on the glass substrate during heating of a patterned microheater are found to migrate towards the hot microheater line due to thermocapillary migration, 14 leading to self-assembly of pores in the same shape as the microheater line. Theoretical calculations and experimental velocity measurements confirm the thermocapillary nature of bubble motion.…”

mentioning

confidence: 93%

Thermally assisted spatially directed pore formation in poly-dimethylsiloxane (PDMS)

Banait

Vishwakarma

Choobineh

et al. 2013

Applied Physics Letters

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This paper reports a method for spatially directed, self-assembled pore formation in poly-dimethylsiloxane (PDMS) that results in through-membrane pores only at desired locations. This method is based on bubble generation in uncured PDMS and subsequent bubble motion towards a hot region in a microfabricated chip containing a heater device due to thermocapillary effect. Pore formation in straight-line and semi-circular shapes is demonstrated. Coupled physics behind the pore formation and alignment process is described. Results show that the mechanism of pore formation can be controlled by changing the microheater temperature.

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Microheater platform for selective detachment of DNA

Cited by 12 publications

References 18 publications

High speed DNA denaturation using microheating devices

High speed DNA denaturation using microheating devices

Heat transfer enhancement in a lithium-ion cell through improved material-level thermal transport

Thermally assisted spatially directed pore formation in poly-dimethylsiloxane (PDMS)

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