Microindentation on Gelatin Films with a Spherical Indenter -- A Viscoelastic Analysis

Ni, Beta Y.; Bisson, Gary; Tsou, Andy H.

doi:10.1557/proc-308-489

Cited by 8 publications

(2 citation statements)

References 10 publications

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“…Microindentation is a suitable method for investigating visco-elastic properties of biopolymers, like gelatin [56][57][58][59]. The load-depth curves and obtained values for reduced modulus, E r , and hardness, H are presented in Figure 3c,d, respectively.…”

Section: Microindentationmentioning

confidence: 99%

3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development, Characterization and Bioavailability Prediction

et al. 2021

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Gelatin-polyvinylpyrrolidone (PVP) and gelatin-poly(vinyl alcohol) (PVA) mucoadhesive buccal films loaded with propranolol hydrochloride (PRH) were prepared by semi-solid extrusion 3D printing. The aim of this study was to evaluate the effects of the synthetic polymers PVP and PVA on thermal and mechanical properties and drug release profiles of gelatin-based films. The Fourier-transform infrared spectroscopy showed that hydrogen bonding between gelatin and PVP formed during printing. In the other blend, neither the esterification of PVA nor gelatin occurred. Differential scanning calorimetry revealed the presence of partial helical structures. In line with these results, the mechanical properties and drug release profiles were different for each blend. Formulation with gelatin-PVP and PRH showed higher tensile strength, hardness, and adhesive strength but slower drug release than formulation with gelatin-PVA and PRH. The in silico population simulations indicated increased drug bioavailability and decreased inter-individual variations in the resulting pharmacokinetic profiles compared to immediate-release tablets. Moreover, the simulation results suggested that reduced PRH daily dosing can be achieved with prolonged-release buccal films, which improves patient compliance.

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Section: Microindentationmentioning

confidence: 99%

3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development, Characterization and Bioavailability Prediction

et al. 2021

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“…The load pulse followed by the measurement of the indent recovery after the complete unloading by itself is not a new procedure in mechanical tests of materials (see for example [17], reporting the studies of the microhardness of glasses at elevated temperature). We do not know, however, about similar systematic studies in nanoindentation with the exception of some cases, where only some elements of a step-loading are used [18][19][20][21][22][23][24].…”

Section: Methodsmentioning

confidence: 99%

Determination of viscoelastic material parameters by step-loading nanoindentation

Dub¹,

Trunov²

2008

J. Phys. D: Appl. Phys.

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Methodical aspects of studies of the time-dependent mechanical properties of materials by step-loading nanoindentation using a Berkovich indenter have been considered. The possibility is shown to determine the viscosity and relaxation time of viscoelastic materials from experiments on step-loading nanoindentation. The potentialities of step-loading nanoindentation have been demonstrated by the example of the photoplastic effect in chalcogenide glasses.

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Dynamic nanoindentation of some polyolefins

Bouaita

Bull

Palacio

et al. 2006

Polymer Engineering & Sci

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Nanoindentation tests have been conducted on five different polyolefins, comprising a high density polyethylene, a low density polyethylene, a linear low density polyethylene, a polypropylene homopolymer and a polypropylene copolymer. The nanoindenter was fitted with a "Dynamic Stiffness Measurement" (DSM) facility that permits measurement of storage modulus and loss modulus at frequent intervals during an indentation test. The results were quite scattered, especially those for the loss modulus, and methods of processing the data to derive meaningful results were examined and are discussed. The storage modulus measurements were found to give the same stiffness ranking as the monotonic load-displacement data when comparing indentations on the same material. Some correlation was found between the storage modulus and fractional crystallinity. An averaging procedure was developed for the loss modulus values that appeared to give a consistent assessment of the dissipation properties of the different materials. Analysis of the monotonic component of the load-displacement data indicated that the nature of the deformation changed from mainly elastic/viscoelastic to mainly viscoelastic/plastic during the course of the indentation tests. POLYM. ENG. SCI., 46: 1160 -1172, 2006.

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Microindentation on Gelatin Films with a Spherical Indenter -- A Viscoelastic Analysis

Cited by 8 publications

References 10 publications

3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development, Characterization and Bioavailability Prediction

3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development, Characterization and Bioavailability Prediction

Determination of viscoelastic material parameters by step-loading nanoindentation

Dynamic nanoindentation of some polyolefins

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