Microinjection of CART peptide 55–102 into the nucleus accumbens blocks amphetamine-induced locomotion

Kim, Jeong-Hoon; Creekmore, Elizabeth; Vezina, Paul

doi:10.1016/j.npep.2003.10.001

Cited by 64 publications

(61 citation statements)

References 23 publications

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“…injection of cocaine, it was found that the LMA effects of cocaine were blunted (Table 1). This effect of CART has also been reported with respect to amphetamine-induced LMA [34]. So by itself, CART has no apparent effect when injected into the accumbens, but when combined with psychostimulants, it will blunt drug-stimulated LMA [33].…”

Section: Effects Of Cart Peptide On the Locomotor Effects Of Cocaine supporting

confidence: 56%

CART peptides as modulators of dopamine and psychostimulants and interactions with the mesolimbic dopaminergic system

Hubert

Jones

Moffett

et al. 2008

Biochemical Pharmacology

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CART (cocaine-and amphetamine-regulated transcript) peptides are peptidergic neurotransmitters that are widely but specifically distributed throughout the brain, gut and other parts of the body. They are found in many brain regions associated with drug addiction including the nucleus accumbens, ventral tegmental area and ventral pallidum. Injections of CART 55-102 into the nucleus accumbens have no effect on basal locomotor activity. However, an injection of CART just before an i.p. injection of cocaine reduces the locomotor activating effects of cocaine. These and other data suggest that CART in the accumbens blunts the effects of cocaine. A hypothesis is that CART is homeostatic in the accumbens and tends to oppose large increases in dopamine signaling. These actions would therefore be able to regulate the effects of some abused drugs such as the psychostimulants.

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Section: Effects Of Cart Peptide On the Locomotor Effects Of Cocaine supporting

confidence: 56%

CART peptides as modulators of dopamine and psychostimulants and interactions with the mesolimbic dopaminergic system

Hubert

Jones

Moffett

et al. 2008

Biochemical Pharmacology

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“…These results are consistent with the findings of previous studies that intra-NAcc CART infusions reduced locomotion produced by i.p. injections of amphetamine [ 21 ] and cocaine [ 18 ], and inhibits the expression of behavioral sensitization to cocaine [ 41 ]. Thus, CART in the NAcc appears to functionally inhibit the activating/reinforcing effects of psychostimulants.…”

Section: Discussionmentioning

confidence: 99%

“…Our findings are in agreement with previous studies that found an inhibitory effect of intra-NAcc CART peptide on psychostimulant-induced behaviors. Intra-NAcc CART inhibits locomotion produced by systemic cocaine [ 18 ] and amphetamine [ 21 ]. Thus, CART peptide in the NAcc may function not only to modulate the motor properties but also the motivational/ rewarding properties of psychostimulants.…”

Section: Discussionmentioning

confidence: 99%

“…Intra-NAcc injections of CART alone have no effect on locomotion, but inhibit locomotion produced by systemic injections of amphetamine [ 21 ] and cocaine [ 18 ]. Because dopamine is thought to be a critical mediator of locomotor activity [ 29 ] and the actions of psychostimulants [ 38 ], CART may modulate locomotor activity and influence the action of psychostimulants by altering dopamine activity.…”

Section: Introductionmentioning

confidence: 99%

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Injection of CART (cocaine- and amphetamine-regulated transcript) peptide into the nucleus accumbens reduces cocaine self-administration in rats

Jaworski

Hansen

Kuhar

et al. 2008

Behavioural Brain Research

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Cocaine-and amphetamine-regulated transcript (CART) peptides appear to modulate various effects of psychostimulant drugs. Injections of CART peptide into the nucleus accumbens (NAcc) inhibit locomotion produced by systemic injections of the psychostimulants cocaine and amphetamine. Intra-NAcc injections of CART peptide also inhibit locomotion produced by microinfusions of dopamine into the NAcc, suggesting that the effects of CART peptides may be due to an interaction with the dopaminergic system in the NAcc. We sought to determine if this inhibitory effect of CART peptide generalizes to other measures of dopaminergic function such as reward/reinforcement by testing the effect of bilateral intra-NAcc CART infusions (0, 0.25, 1.0 and 2.5 µg per side) on cocaine and food self-administration. One group of rats self-administered cocaine (0.75 mg/kg per 140 µl IV infusion) on a progressive ratio schedule. A separate group received 45 mg food pellets on the same progressive ratio schedule. Bilateral intra-NAcc injections of CART peptide dose-dependently decreased the number of cocaine infusions, the breakpoint of cocaine self-administration, and the total number of bar presses on the cocaine-associated lever. There were no effects of CART injections on the break point for food reward. Thus, we conclude that injections of CART into the NAcc appear to functionally antagonize a major site of action for cocaine self-administration in rats.

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“…Esse efeito de aumento de locomoção pode ser inibido pela administração prévia de antagonista de receptor dopaminérgico, haloperidol (KIMMEL et al, 2000). Já a injeção de CART no núcleo acumbens, por si só, não altera a atividade locomotora, mas, quando injetado concomitantemente com drogas psicoestimulantes, diminui a atividade locomotora geral induzida por drogas (JAWORSKI et al, 2003;KIM et al, 2003). Em estudo de auto-administração de cocaína, a injeção no núcleo acumbens de CART levou a diminuição do efeito reforçador da droga (JAWORSKI et al, 2008).…”

Section: Cocaine and Amphetamine Regulated Trascripit (Cart)unclassified

Estudo neuroquímico do núcleo pré-mamilar ventral nos animais submissos durante os encontros agonísticos sociais.

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Microinjection of CART peptide 55–102 into the nucleus accumbens blocks amphetamine-induced locomotion

Cited by 64 publications

References 23 publications

CART peptides as modulators of dopamine and psychostimulants and interactions with the mesolimbic dopaminergic system

CART peptides as modulators of dopamine and psychostimulants and interactions with the mesolimbic dopaminergic system

Injection of CART (cocaine- and amphetamine-regulated transcript) peptide into the nucleus accumbens reduces cocaine self-administration in rats

Estudo neuroquímico do núcleo pré-mamilar ventral nos animais submissos durante os encontros agonísticos sociais.

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