Microinvasive Carcinoma of the Vulva

Wilkinson, Edward J.; Rico, M. Joyce; Pierson, K. Kendall

doi:10.1097/00004347-198201000-00005

Cited by 113 publications

(29 citation statements)

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“…The conventional measuring method was chosen mainly based on practical issues 11 ; the adjacent dermal papilla can be found in all sites of the vulva, is not altered by variations in the depth of rete ridges, and the measurement is not significantly influenced by hyperkeratosis, tumor surface ulceration, or adjacent epithelial hyperplasia. Wilkinson et al 16 considered different measuring methods in one of his first studies about microinvasive carcinomas of the vulva and states that the difficulty in measuring from the deepest rete ridge (the alternative method used in this study) is that the overlying epithelium at the site of the neoplasm may itself be neoplastic and would be a variable site of measurement. The problem of variability can be argued; in our study no cases with the invasive overlying epithelium were seen.…”

Section: Discussionmentioning

confidence: 99%

An alternative way to measure the depth of invasion of vulvar squamous cell carcinoma in relation to prognosis

et al. 2015

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Depth of invasion is an important prognostic factor for patients with vulvar squamous cell carcinoma. The aim of this study was to identify the most optimal method of measuring the depth of invasion in relation to the individual outcome in patients with vulvar squamous cell carcinoma. Data of 175 consecutive patients with a primary vulvar squamous cell carcinoma with known lymph node status, treated in the Radboud University Medical Center, the Netherlands (2000Netherlands ( -2010, were stored in a database. At pathology review of 148 (85%) cases, depth of invasion was measured using the conventional and alternative methods. Clinical and pathological characteristics of patients with a change in FIGO stage were compared with those without a change in stage. In 148 vulvar squamous cell carcinoma patients, the median depth of invasion was shown to be decreased from 5.5 mm (range 1.1-20) using the conventional method to 3.6 mm (range 0.2-20) using the alternative method (Po0.05). This led to a change in the FIGO stage in 13 of the 148 (9%) patients and a change in depth of invasion from 3.5 to 0.2 mm in one patient (1%) with FIGO stage IIIA. Of all 69 stage 1B patients, 13 (19%) were downstaged to stage IA. The downstaged patients developed less recurrences (15% vs 39%) and had a higher disease-specific survival (100% vs 84%) compared with the patients who remained FIGO stage IB. Using the alternative method for measuring the depth of invasion in tumors of vulvar squamous cell carcinoma patients, 19% of the patients with a FIGO stage IB tumor might be treated without groin surgery resulting in less treatment-related morbidity. The results are promising but more prospective data on a higher number of patients are necessary.

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Section: Discussionmentioning

confidence: 99%

An alternative way to measure the depth of invasion of vulvar squamous cell carcinoma in relation to prognosis

et al. 2015

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“…8 The trouble point of this statement was the method of measuring the depth of invasion. 9 At least 5 methods for vertical measurement of a vulvar squamous cell carcinoma were referred to the ISGYP committee with different landmarks used for calculation. 7 Wilkinson first proposed the definition of depth of invasion as the measurement of the tumor from the epithelial stromal (dermal) junction of the adjacent most superficial dermal papillae to the deepest point of invasion, and distinguished the depth of invasion measurement from the thickness of the tumor 7,9 (Fig.…”

Section: Rationale and Historical Backgroundmentioning

confidence: 99%

Superficially Invasive Carcinoma of the Vulva: Diagnosis and Treatment

Preti

Rouzier

Mariani³

et al. 2005

Clinical Obstetrics and Gynecology

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“…Wegen besonderer Bedeutung für die Ausbreitung und die Therapieplanung ist die präzise Angabe der Invasionstiefe erforderlich. Als Definition haben sich die ISGP und die ISSVD auf die Entfernung zwischen der tiefsten Invasion zur höchsten benachbarten Papille geeinigt [65].…”

Section: Invasives Karzinomunclassified

“…Ist das Karzinom bei einer jüngeren Frau in der Nähe der Klitoris lokalisiert, sodass die Sicherheitszone von 1 cm nicht mit einem Erhalt der Klitoris vereinbar wäre, so ist in einem Zentrum mit spezieller Erfahrung unter optimaler histopathologischer Kontrolle ein Kompromiss möglich. Erst wenn die Infiltrationstiefe von 1,0 mm überschritten ist, so ist eine inguinofemorale Lymphknotendissektion erforderlich [5,8,23,37,65]. Bei klar einseitiger Lokalisation des Karzinoms ist eine ausschließlich ipsilaterale Lymphknotendissektion möglich, da sich bei dieser Situation nur sehr selten (<1%) Metastasen in den kontralateralen Leistenlymphknoten finden [7].…”

Section: Stadium T1unclassified

Vulvakarzinom

2004

Urologe [A]

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Vulvar cancer is a rare entity. It appears mostly in older women aged 70-79 years with a slow tendency to younger age. More than 90% of the tumors show a squamous differentiation. The correspondent preneoplasia is VIN 3. This lesion occurs in women mostly younger than 35 years. Experts assume vulvar cancer to appear in two different types:HPV-induced type in younger women and non-HPV-dependent type in older women. The preneoplasia VIN 3 already should be treated by resection or destruction. Invasive carcinomas stage I or II can be treated by wide local excision. The inguinofemoral lymph nodes should be resected if invasion exceeds 1 mm in depth. In larger primary tumors, vulvectomy with bilateral inguinofemoral node dissection is indicated. In advanced tumor stages, multimodal concepts are applied: primary radiotherapy or radiochemotherapy may precede a salvage operation.

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Microinvasive Carcinoma of the Vulva

Cited by 113 publications

References 0 publications

An alternative way to measure the depth of invasion of vulvar squamous cell carcinoma in relation to prognosis

An alternative way to measure the depth of invasion of vulvar squamous cell carcinoma in relation to prognosis

Superficially Invasive Carcinoma of the Vulva: Diagnosis and Treatment

Vulvakarzinom

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