2022
DOI: 10.21203/rs.3.rs-2104890/v1
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Microkinetics of Lidocaine and Bupivacaine Transfer across Myelinated Nerve Fibre

Abstract: Background The present study aimed to predict the time to onset and duration of action of two local anesthetics (lidocaine and bupivacaine) based on the experimental dimensions of a typical nerve and experimental octanol/water partition coefficients. Methods We started our compilation of experimental data with a numerical solution of the diffusion equation of transfer of lidocaine and bupivacaine across the axon membrane at the region of the node of Ranvier (axolemma) and across the Schwann cell. By includin… Show more

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