Micromachined heated chemical reactor for pre-column derivatisation

Eijkel, Jan C.T.; Prak, A.; Cowen, Simon; Craston, Derek H.; Manz, Andreas

doi:10.1016/s0021-9673(98)00459-2

Cited by 29 publications

(21 citation statements)

References 13 publications

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“…The rapid advances in Microfluidics and Nanofluidics fields have led to compact microfluidic devices and emerging cell applications that offer potential benefits in providing lab-on-a-chip (LOC) platforms for disease diagnosis and treatment [1][2][3][4][5][6][7]. Thanks to the progress in micro/nano fabrication techniques, the microfluidic applications in various subjects, such as DNA analysis [1][2][3], cytometry [4,5], micromixing [6], microreactors [7], cell cycle synchronization [8], drug delivery [9] and extraction of blood plasma [10], have appeared over the past decades.…”

Section: Introductionmentioning

confidence: 99%

“…Thanks to the progress in micro/nano fabrication techniques, the microfluidic applications in various subjects, such as DNA analysis [1][2][3], cytometry [4,5], micromixing [6], microreactors [7], cell cycle synchronization [8], drug delivery [9] and extraction of blood plasma [10], have appeared over the past decades. One of the distinct advantages of the microfluidic systems is their capability to be integrated into other systems.…”

Section: Introductionmentioning

confidence: 99%

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Microparticle Inertial Focusing in an Asymmetric Curved Microchannel

Özbey

Karimzadehkhouei

Alijani

et al. 2018

Fluids

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Inertial Microfluidics offer a high throughput, label-free, easy to design, and cost-effective solutions, and are a promising technique based on hydrodynamic forces (passive techniques) instead of external ones, which can be employed in the lab-on-a-chip and micro-total-analysis-systems for the focusing, manipulation, and separation of microparticles in chemical and biomedical applications. The current study focuses on the focusing behavior of the microparticles in an asymmetric curvilinear microchannel with curvature angle of 280 • . For this purpose, the focusing behavior of the microparticles with three different diameters, representing cells with different sizes in the microchannel, was experimentally studied at flow rates from 400 to 2700 µL/min. In this regard, the width and position of the focusing band are carefully recorded for all of the particles in all of the flow rates. Moreover, the distance between the binary combinations of the microparticles is reported for each flow rate, along with the Reynolds number corresponding to the largest distances. Furthermore, the results of this study are compared with those of the microchannel with the same curvature angle but having a symmetric geometry. The microchannel proposed in this study can be used or further modified for cell separation applications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microparticle Inertial Focusing in an Asymmetric Curved Microchannel

Özbey

Karimzadehkhouei

Alijani

et al. 2018

Fluids

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“…In many of these areas temperature control is of great importance, for instance in maintaining mild conditions for bio-chemical reactions (DeWitt, 1999;Fletcher et al, 2002;Jähnisch et al, 2004;Eijkel et al, 1998). Temperature control can be achieved by means of in-chip heating devices (Keuren et al, 2005;Wijngaards et al, 2004;Lao et al, 2000;, out-of-chip heating devices (Kopp et al, 1998;Swarts et al, 2008), and non-contact heating (or cooling) (Oda et al, 1998;Sundaresan et al, 2005;Slyadnev et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

The effect of design parameters on temperature of a heated microsystem

Swarts

Janssen

Boom

2011

Chemical Engineering Research and Design

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“…The micro-fabricated devices have attracted considerable interest for their potential in the miniaturization and integration of an entirely chemical or biological analytical process on a single chip-based device [6,7,8]. Applications of microchipbased capillary electrophoresis (CE) have been successfully carried out in many fields of biologic analysis, such as DNA fragments analysis [9], PCR amplification [10], DNA sequencing [11], and separation of amino acids [12], biogenic amines [13] and proteins [14]. The field of bioanalytical chemistry will be immeasurably accelerated by the introduction of microchip-based analysis devices.…”

Section: Introductionmentioning

confidence: 99%

Influence of soluble polymer polyvinylpyrrolidone on separation of small peptides and amino acids by microchip-based capillary electrophoresis

et al. 2002

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In microchip-based capillary electrophoresis, the resolution and separation efficiency of small peptides and amino acids can be noticeably improved by adding a low molecular weight (30,000) soluble polymer additive, polyvinypyrrolidone in the separation medium. Several separation conditions such as injection time and electrophoretic buffer have been investigated and optimized. Using an electro-stacking scheme, the resolution and separation efficiency of small peptides and amino acids can be enhanced significantly. Under the optimal conditions, the separation of fluorescein isothiocyanate Isomer I-labeled small peptides and amino acids was successfully achieved within 100 s.

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Micromachined heated chemical reactor for pre-column derivatisation

Cited by 29 publications

References 13 publications

Microparticle Inertial Focusing in an Asymmetric Curved Microchannel

Microparticle Inertial Focusing in an Asymmetric Curved Microchannel

The effect of design parameters on temperature of a heated microsystem

Influence of soluble polymer polyvinylpyrrolidone on separation of small peptides and amino acids by microchip-based capillary electrophoresis

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