Nonpersistent joints are prevalent in engineering rock masses and are sensitive to cyclic loads induced by geological movements and engineering disturbances. Therefore, studying the fatigue mechanisms of rock masses with nonpersistent joints under cyclic compressive loads is crucial for ensuring the rational design and long‐term stability of rock engineering structures. Based on laboratory experiments, this study employed the discrete element method to create specimens with different nonpersistent joints, and uniaxial compressive cyclic loading tests were conducted on these specimens with different maximum cyclic stress levels. The results show that the joint inclination significantly affects the characteristics of jointed rock, such as deformation modulus, irreversible strain, energy evolution, and crack characteristics. Increasing the maximum stress in the stress path results in a rapid release of hysteretic energy in the jointed regions of the rock, which leads to an exponential decrease in fatigue life while an increase in initial irreversible strain, final irreversible strain, and hysteretic energy density. Additionally, the shear fracture zones on both sides of the model expand, and the propagation and merging of cracks between joints become more extensive and complex. The results are significant for studying rock fatigue instability and structure engineering design.